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Gel-type composite alcohol no-wash disinfectant and preparation method thereof

A disinfectant and compound alcohol technology, applied in the directions of drug combination, pharmaceutical formulation, aerosol delivery, etc., can solve the problems of inconvenient disinfection work, unfavorable health and skin protection of medical staff, complex components, etc., and achieve long-lasting sterilization and disinfection time. , Good hand adhesion, not easy to flow loss effect

Inactive Publication Date: 2018-05-18
CHANGJIANGMAI MEDICINE SCI & TECH BEIJING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing hand sanitizers have complex components, cannot volatilize after disinfection, and remain on the hands. However, medical staff use hand sanitizers hundreds of times a day. Frequent use will lead to excessive accumulation of non-volatile components, which will affect the disinfection effect. Some disinfection time is too long, which brings inconvenience to the actual disinfection work; long-term frequent use is extremely unfavorable to the health and skin protection of medical staff; experience feelings

Method used

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  • Gel-type composite alcohol no-wash disinfectant and preparation method thereof
  • Gel-type composite alcohol no-wash disinfectant and preparation method thereof
  • Gel-type composite alcohol no-wash disinfectant and preparation method thereof

Examples

Experimental program
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Effect test

preparation example Construction

[0031] In the preparation method disclosed in the present invention, the required content of ethanol and isopropanol is first mixed to obtain a solution of the two to obtain a complex alcohol, and then the complex alcohol is used for further preparation of the gel-type disposable disinfectant.

[0032] The gelling agent used in the present invention is carboresin, cellulose gelling agent, and this kind of material has good stability, water absorption, and the solution is completely transparent after dissolving in water, clarifies, itself is safe to human body, nontoxic and harmless . Among them, Carbomer is a chemically cross-linked polymer of acrylic acid or acrylate and allyl ether, including polyacrylic acid (homopolymer) and acrylate / C10-30 alkyl acrylate cross-linked copolymer (copolymer It has the functions of thickening, suspending, stabilizing the emulsification system, regulating the release of water and active substances, and is a rheology-modified thickener widely u...

Embodiment 1

[0043] The gel type complex alcohol disposable disinfectant disclosed in this embodiment 1 comprises the following components:

[0044]

[0045] For the remaining sterile water, the component content is expressed in mass percent.

[0046] According to the preparation method disclosed in the present invention, the stirring temperature is controlled at 20°C.

[0047] After filtering, it can be used after passing the test, or it can be sealed and stored after filling, and it can be used within two years.

[0048] The disinfectant of this embodiment was stored at 37° C. for 90 days, and the rate of decline of the effective bactericidal component was within 10%, which met the requirements of the disinfection technical specification.

[0049] Microbial killing test: under the condition of 20°C±1°C, the gel-type compound alcohol hand sanitizer is used for 1 minute, and the average killing logarithm of Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, and Candida al...

Embodiment 2

[0051] The gel type compound alcohol disposable disinfectant disclosed in present embodiment 2 comprises the following components:

[0052]

[0053]

[0054] For the remaining sterile water, the component content is expressed in mass percent.

[0055] Prepared according to the method disclosed in the present invention, the stirring temperature is controlled at 15°C.

[0056] After filtering, it can be used after passing the test, or it can be sealed and stored after filling, and it can be used within two years.

[0057] The disinfectant of this embodiment was stored at 37° C. for 90 days, and the rate of decline of the effective bactericidal component was within 10%, which met the requirements of the disinfection technical specification.

[0058] Microbial killing test: under the condition of 20℃±1℃, the average killing logarithm of Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and Candida albicans with gel-type compound alcohol disposable disinfectant...

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Abstract

The invention discloses a gel-type composite alcohol no-wash disinfectant, which comprises 0.1-1% of polyhexamethylene guanidine, a polyhexamethylene guanidine derivative or a combination thereof, 40-50% of composite alcohol, 1-4% of a moisture-retention skin-protecting agent, and 0.1-2% of a gelling agent, with the balance being sterile water, wherein polyhexamethylene guanidine is polyhexamethylene mono-guanidine and polyhexamethylene biguanide, the polyhexamethylene guanidine derivative is hydrochloride and phosphate of polyhexamethylene guanidine, the composite alcohol is a combination ofethanol and isopropanol, and the moisture-retention skin-protecting agent is a combination of one or more of glycerin, protein hydrolysate, lanolin and polyethylene glycol which has the degree of polymerization in a range of 400-6000. The disinfectant can fast perform sterilization, is non-toxic to the human body, doesn't make the skin degreased or cracked, and is free of components that have peculiar smell. The disinfectant has high adhesive force to hand, is not prone to flow or lose, can effectively fix antiseptic components, and makes disinfection long-lasting.

Description

technical field [0001] The invention belongs to the field of disinfectants, and in particular relates to a gel-type compound alcohol disposable disinfectant and a preparation method thereof. Background technique [0002] At present, the situation of nosocomial infection has attracted more and more attention from domestic and foreign medical circles, and the hand hygiene and disinfection of medical staff is an important link in the prevention of nosocomial infection. The classic method of washing hands with soapy water before surgery has gradually been eliminated. With the continuous innovation in the research and development of surgical hand disinfectants, a series of changes have taken place in the surgical hand disinfection methods, showing diversity and simplification. At present, ethanol is often used as the main component of disinfectant, and other disinfectant ingredients are added to synergize. The purpose of hand cleaning and disinfection can be achieved in a short t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/785A61K31/045A61K38/01A61K31/047A61K35/36A61K31/77A61K9/06A61P17/00A61P31/02A61P31/04A61P17/16
Inventor 戴彦榛史瑞雪刘海燕
Owner CHANGJIANGMAI MEDICINE SCI & TECH BEIJING