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Ferrocene-lanthanide-series metal compound and preparation method and application thereof

A technology of lanthanide metals and ferrocene derivatives, which is used in the synthesis and application of metal organic compound self-assembly complexes, can solve the problems of broad spectrum, high toxicity and patient harm, and achieve low cost, convenient process operation, The effect of mild reaction conditions

Active Publication Date: 2018-05-29
NANJING UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among the traditional cytotoxic drugs, cisplatin compounds and their derivatives cause great harm to patients due to their broad-spectrum and high toxicity. Focus

Method used

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  • Ferrocene-lanthanide-series metal compound and preparation method and application thereof
  • Ferrocene-lanthanide-series metal compound and preparation method and application thereof
  • Ferrocene-lanthanide-series metal compound and preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment example 1

[0029] Synthesis of the target compound: take ferrocenyl selenide as the synthetic raw material, react with sodium borohydride for 0.5h in ice bath under nitrogen protection, room temperature for two hours, add N,N-bis (2-Bromoethyl) coumarin methylamine compound, control the reaction temperature at 5-30°C, react for 5-48 hours, and obtain the target ligand product, wherein the molar ratio of the reaction raw materials is ferrocene selenide: sodium borohydride: two Bromide is 1:3:1. Spin dry the reaction solution. Dichloromethane was extracted with water, the lower layer was taken to clear yellow solution, dried over anhydrous magnesium sulfate, a little silica gel was added to the obtained solution, and spin-dried. Chromatographic column separation, flushing agent n-hexane: ethyl acetate = 3:1. The obtained light yellow intermediate product. Weigh NaClO 4 and Eu(CH 3 CH 2 COO) 3 Dissolve in ethanol, stir well, add ferrocene derivatives, use propionic acid to adjust the ...

Embodiment example 2

[0037] Synthesis of the target compound: similar to Case 1, change the raw material of dibromide to N,N-bis(2-bromoethyl)rhodamine methylamine compound, control the reaction temperature at 5-30°C, and react for 5-48 hours to obtain the intermediate NaClO 4 and Eu(CH 3 CH 2 COO) 3 Continue to react at room temperature for 12 to 24 hours, precipitate out, wash with water and ethanol three times respectively, and obtain the target product, wherein the molar ratio of the reaction raw materials is NaClO 4 : Eu(CH 3 CH 2 COO) 3 : The ratio of ferrocene derivatives is 2:1:1.

[0038] Phototherapy biological experiments:

[0039] Cell line: same as Case 1

[0040] Light-controlled diagnosis and treatment: Take the above-mentioned compound drugs with different concentrations (1.5, 15, 30, 50, 75 and 100 μM) in a quartz dish, use a fluorescent confocal microscope to record the cell morphology and fluorescence state, and at room temperature, after 5 minutes of light exposure Cel...

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Abstract

The invention discloses a new construction idea and synthesis method of a ferrocene-lanthanide-series metal compound. The compound has the advantages of being low in cost, mild in reaction condition and convenient to operate during the process. Meanwhile, according to the new application of the compound, a ferrocene derivative with potential biological activity and lanthanide-series metal ions with fluorescence signal tracing are self-assembled, the anti-cancer activity is generated under light induction, and meanwhile a fluorescence signal is obtained. In this way, integrated application of light-control diagnosis and treatment is achieved. The ferrocene-lanthanide-series metal compound has important reference value on development of novel intelligent medicine capable of integrating light-control tumor resistance and motoring.

Description

technical field [0001] The invention relates to the synthesis and application of a metal organic compound self-assembly compound, in particular to a ferrocene-lanthanide metal compound and its preparation method and application. Background technique [0002] Cancer is predicted to be the "first killer" of human beings in the 21st century, so cancer control has become the focus of global health strategies. my country has become the world's largest cancer country. Cancer not only seriously threatens the life and health of our people, but also causes a heavy burden to the family, society and the country. Among the traditional cytotoxic drugs, cisplatin compounds and their derivatives cause great harm to patients due to their broad-spectrum and high toxicity. Focus. [0003] Compared with traditional controllable response materials commonly used in pH, chemical substances, electricity, temperature and other control methods, light is considered to be an ideal control source bec...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K49/00A61P35/00
CPCA61K41/0042A61K49/0019
Inventor 景苏瞿建吉玮
Owner NANJING UNIV OF TECH
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