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Coenzyme Q10, octacosanol and cyclodextrin multi-element supermolecule clathrate compound and preparation method thereof

A technology of octacosanol and cyclodextrin, which is applied in the fields of medicine and health care products to achieve the effect of excellent antioxidant properties and the effect of improving solubility

Active Publication Date: 2018-05-29
SHENYANG WANJIA INST OF BIOLOGICAL TECH RES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

⑥ Chinese patent ZL200610046307.0 discloses a water-soluble coenzyme Q 10 Hydroxypropyl-β-cyclodextrin inclusion compound and preparation method, the above patent documents are all related to coenzyme Q 10 Cyclodextrin inclusion compound with octacosanol alone, not related to the technology of the present invention

Method used

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  • Coenzyme Q10, octacosanol and cyclodextrin multi-element supermolecule clathrate compound and preparation method thereof
  • Coenzyme Q10, octacosanol and cyclodextrin multi-element supermolecule clathrate compound and preparation method thereof
  • Coenzyme Q10, octacosanol and cyclodextrin multi-element supermolecule clathrate compound and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] Oxidized coenzyme Q of the present invention 10 The ternary supramolecular clathrate with octacosanol cyclodextrin is prepared as follows: take 30 parts by weight of β-cyclodextrin, add 150 parts by weight of water and mix, heat to 60°C, and then add 10 parts by weight of oxidation Coenzyme Q 10 and 1 part by weight of octacosanol, stirred into a paste, put into a colloid mill, circulated and ground 15 times, discharged, added water until the solid content reached 12%, and spray-dried to obtain oxidized coenzyme Q 10 Cyclodextrin ternary supramolecular inclusion compound compounded with octacosanol. Determination of coenzyme Q in clathrate by HPLC and gas chromatography respectively 10 and encapsulation efficiency of octacosanol, coenzyme Q 10 The encapsulation rate was 69.2%, and the encapsulation rate of octacosanol was 65.3%.

Embodiment 2

[0055] Reduced coenzyme Q of the present invention 10 The ternary supramolecular inclusion compound with octacosanol cyclodextrin is prepared as follows: Take 50 parts by weight of β‐cyclodextrin, add 250 parts by weight of water, mix, heat to 65°C, and then add 10 parts by weight Reduced coenzyme Q 10 and 2 parts by weight of octacosanol, stirred into a paste, put into a colloid mill, circulated and ground 20 times, discharged, added water until the solid content reached 13%, and freeze-dried to obtain reduced coenzyme Q 10 Cyclodextrin ternary supramolecular inclusion compound compounded with octacosanol. Determination of coenzyme Q in clathrate by HPLC and gas chromatography respectively 10 and encapsulation efficiency of octacosanol, coenzyme Q 10 The encapsulation rate was 89.1%, the encapsulation rate of octacosanol was 85.3%, and the calculated encapsulation ratio was 1:0.33:6.06.

Embodiment 3

[0057] Oxidized coenzyme Q of the present invention 10 The preparation method of the ternary supramolecular inclusion complex with octacosanol cyclodextrin is as follows: take 100 parts by weight of β-cyclodextrin, add 400 parts by weight of water and mix, heat to 90°C, and then add 10 parts by weight of oxidized coenzyme Q 10 and 5 parts by weight of a mixture of 50% octacosanol C22 to C36 higher fatty alkanol, stirred into a paste, put into a colloid mill, and circulated for 20 times of grinding, discharging, adding water until the solid content reaches 11%, Carry out spray drying, obtain oxidized coenzyme Q 10 Cyclodextrin ternary supramolecular inclusion compound compounded with octacosanol. Determination of coenzyme Q in clathrate by HPLC and gas chromatography respectively 10 and encapsulation efficiency of octacosanol, coenzyme Q 10 The encapsulation rate was 85.3%, and the encapsulation rate of octacosanol was 81.4%.

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Abstract

The invention discloses a preparation method of a coenzyme Q10, octacosanol and cyclodextrin multi-element supermolecule clathrate compound, and belongs to the technical field of medicines and health-care products. The coenzyme Q10, octacosanol and cyclodextrin multi-element supermolecule clathrate compound has better treatment and health-care function on high blood fat and other cardiovascular diseases, mountainhypoxia, diabetes, and hypoimmunity, and is mainly prepared from the following raw materials in parts by weight: 1 part of coenzyme Q10, 0.1 to 1 part of octacosanol, and 3 to 15 partsof cyclodextrin. The coenzyme Q10, octacosanol and cyclodextrin multi-element supermolecule clathrate compound has the characteristics that the clathrate compound can be dispersed into water to forma nanostructure lipid carrier; the dissolvability is larger, the release degree is higher, and the stability is better; the medicine components can be continuously released; the clathrate compound canbe easily dispersed into water at nanometer level, the dissolving and absorbing surface area is expanded, and the physiological activity is higher than the physiological activity of the single two-element clathrate compound and two-component mixture.

Description

technical field [0001] The present invention relates to a kind of coenzyme Q 10 Multi-component supramolecular inclusion compound with octacosanol cyclodextrin and preparation method thereof, the inclusion compound has good therapeutic and health care effects on diseases such as hyperlipidemia and other cardiovascular diseases, high mountain hypoxia, diabetes, low immunity, etc. It belongs to the technical field of medicine and health products. Background technique [0002] coenzyme Q 10 (Coenzyme Q 10 ) is a compound synthesized by the human body. It is named for its side chain-polyisoprenyl polymerization degree of 10 on the six-position of the mother nucleus, and its structure is similar to vitamin K. coenzyme Q 10 reduced coenzyme Q 10 (Co Q 10 h 2 , Ubiquinol, ubiquinol) and oxidized coenzyme Q 10 (Co Q 10 , Ubiquinone, ubiquinone) two forms, CoQ 10 h 2 is Co Q 10 the two-electron reducer. In vivo, Co Q 10 h 2 with CoQ 10 As a type of hydrogen-donating / e...

Claims

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Application Information

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IPC IPC(8): A61K47/69A61K47/24A61K31/122A61K31/045A61P3/06A61P9/00A61P39/00A61P3/10A61P37/04
CPCA61K31/045A61K31/122A61K47/24A61K2300/00
Inventor 董英杰艾莉邹晓峰李晓怡韩亚男李诗丁爽东长青许永超
Owner SHENYANG WANJIA INST OF BIOLOGICAL TECH RES
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