Preparation method of rostafuroxin enteric-coated tablet

Abstract

The invention discloses a rostafuroxin enteric-coated tablet and a preparation method thereof. The preparation method comprises the following steps of (1) respectively screening 70% to 91% of filler,0.3% to 2% of lubricant, 4% to 8% of adhesive, 1% to 5% of disintegrant, and 0.5% to 2% of surfactant; mixing the filler and the adhesive to obtain a mixture; (2) adding pure water into the surfactantto prepare a surfactant water solution with concentration of 1% to 5%, adding 0.5% of rostafuroxin into the water solution, and dissolving by ultrasonic waves, so as to obtain a mixed solution; (3) atomizing and spraying the mixed solution obtained in step (2) into the mixture obtained in step (2), granulating the sprayed mixture, and drying, so as to obtain particles, wherein the percentage refers to the mass percentage of each component in the raw material; (4) granulating the particles obtained in step (3), adding the lubricant to uniformly mix, and tabletting, so as to obtain plain tablets; (5) coating the plain tablets for the second time, so as to obtain the enteric-coated tablet. The preparation method has the advantages that by adopting the preparation technique, the content of particle is uniform, the quality is stable, the loss amount is small, the technology process is simple, and the cost is effectively reduced.

Description

technical field [0001] The invention belongs to the field of medicines, and in particular relates to a preparation method of rotafoxine enteric-coated tablets. Background technique [0002] The main causes of hypertension are genetic factors, mental and environmental factors, age factors, lifestyle factors, drug effects and other diseases. About 60% of them have a family history of hypertension, so it is generally believed that it is caused by polygenic inheritance. If patients with high blood pressure cannot receive timely and effective treatment, they may increase the risk of heart failure, stroke and renal failure. [0003] The pathogenesis of hypertension is generally believed to be caused by sodium retention. However, recent studies have found that its mechanism is far more complex than originally thought. Many studies suggest that although other cardiac hormones, such as digoxin, are also present in human and animal plasma and tissues, only plasma endogenous ouabain...

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Problems solved by technology

However, recent studies have found that the mechanism is far more complex than originally thought

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