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Antibacterial and hemostatic bifunctional material and preparation method thereof

A dual-functional material and cellulose-based technology, which is applied in pharmaceutical formulations, medical science, absorbent pads, etc., can solve the problems of antibacterial hemostasis, coagulation dysfunction, secondary trauma, etc., and achieve good biocompatibility and Non-toxic, easy to scale up industrial production, long-lasting effect of antimicrobial properties

Active Publication Date: 2018-06-15
ZHEJIANG SCI-TECH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Cotton, gauze and non-woven fabrics have been widely used in the medical field as commonly used wound dressings. However, they have the disadvantages of poor liquid absorption, easy adhesion and no antibacterial hemostasis, which makes it difficult to remove during use. , easy to cause secondary trauma
In addition, ineffective hemostasis is more likely to cause serious consequences such as wound infection, hypothermia, coagulation dysfunction, and multiple severe organ failure.
[0003] At present, some existing antibacterial gauzes generally achieve antibacterial purposes by adding antibacterial agents such as antibacterial drugs (such as patent CN101780291A) or nano silver (such as patent CN1291667A), but there are problems of antibacterial drug tolerance and antibacterial properties such as nano silver. The enrichment of agents is still a difficult problem

Method used

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  • Antibacterial and hemostatic bifunctional material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] (1) Mix 0.25g of sodium periodate, 0.25g of polyethyleneimine and 2g of bacterial cellulose in a gel state into 20mL of deionized water, and react in an oven at 80°C for 50 minutes, and the obtained modified bacterial cellulose is coagulated. In colloidal state, wash with deionized water three times, and oven-dry at 60°C to obtain a dual-function bacterial cellulose gel with antibacterial and hemostatic properties.

[0025] (2) Antibacterial test procedure: add 33 g of agar into the container, add deionized water to 1 L, and stir evenly to prepare a solid medium. Add 10 g of tryptone, 5 g of beef extract, and 5 g of sodium chloride into the container, then add deionized water to 1 L, and stir evenly to prepare a liquid medium. The liquid medium and solid medium were divided into 18cm test tubes and Erlenmeyer flasks, and sterilized at 121°C for 30min after sealing. Take out the slant of the strain stored at 4°C, perform aseptic operation, and inoculate it on 3 culture ...

Embodiment 2

[0032] (1) Mix 0.25g of sodium periodate, 0.25g of polyethyleneimine, and 2g of powdered absorbent cotton cellulose into 20mL of deionized water, and react in an oven at 90°C for 20 minutes, and the obtained modified absorbent cotton cellulose is in a powder state , washed three times with deionized water, and oven-dried at 60°C to obtain bifunctional cellulose with antibacterial and hemostatic properties.

[0033] (2) Antibacterial test procedure: add 33 g of agar into the container, add deionized water to 1 L, and stir evenly to prepare a solid medium. Add 10 g of tryptone, 5 g of beef extract, and 5 g of sodium chloride into the container, then add deionized water to 1 L, and stir evenly to prepare a liquid medium. The liquid medium and solid medium were divided into 18cm test tubes and Erlenmeyer flasks, and sterilized at 121°C for 30min after sealing. Take out the slant of the strain stored at 4°C, perform aseptic operation, and inoculate it on 3 culture medium slants. ...

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PUM

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Abstract

The invention discloses an antibacterial and hemostatic bifunctional material and a preparation method thereof. Through oxidation grafting of polyethyleneimine, various forms of powder, film, gel, non-woven fabric or textile are obtained according to different cellulose substrates; the material provided by the invention has both antibacterial and hemostatic properties, and the antibacterial property is durable and stable, and can quickly stop bleeding and diminish inflammation without any medicine; and the preparation method of antibacterial cloth and an antibacterial and hemostatic dressing has the advantages of low reaction temperature, simple condition, low energy consumption, and easy large-scale industrial production.

Description

technical field [0001] The invention relates to an antibacterial and hemostatic dual-function material and a preparation method thereof, belonging to the field of medical dressings. Background technique [0002] Cotton, gauze and non-woven fabrics have been widely used in the medical field as commonly used wound dressings. However, they have the disadvantages of poor liquid absorption, easy adhesion and no antibacterial hemostasis, which makes it difficult to remove during use. , easy to cause secondary trauma hazards. In addition, ineffective hemostasis is more likely to cause serious consequences such as wound infection, hypothermia, coagulation dysfunction, and multiple severe organ failure. [0003] At present, some existing antibacterial gauzes generally achieve antibacterial purposes by adding antibacterial agents such as antibacterial drugs (such as patent CN101780291A) or nano silver (such as patent CN1291667A), but there are problems of antibacterial drug tolerance...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00A61L15/28A61L15/26A61L15/46A61L15/42
CPCA61L15/26A61L15/28A61L15/42A61L15/46A61L26/0019A61L26/0023A61L26/0061A61L26/0066A61L2400/04C08L1/02C08L79/02
Inventor 刘琳张连伟杜晓琳王瑞佳姚菊明
Owner ZHEJIANG SCI-TECH UNIV
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