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A programmable and modular pdms microfluidic chip mold system

A technology of microfluidic chips and programming modules, applied in the field of microfluidics, which can solve the problems of increasing processing costs and time, reducing processing efficiency, and complicated processing processes, and achieves the effects of saving experimental costs, simple device design, and simple operation

Active Publication Date: 2020-02-21
BEIJING UNIV OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Mold processing is a key step in the preparation of PDMS microfluidic chips. The processing process is complex, the equipment cost is high, the time is long, and the micro-processing experience and technical requirements of the experimenters are high.
In actual use, for microfluidic chips with different functions, it is necessary to repeat photolithography, inversion, packaging and other processes, which not only reduces the processing efficiency, but also increases the processing cost and time

Method used

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  • A programmable and modular pdms microfluidic chip mold system
  • A programmable and modular pdms microfluidic chip mold system
  • A programmable and modular pdms microfluidic chip mold system

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] select image 3 The four-piece silicon wafer mold module in the middle is used for PDMS inversion, and its functions are H-shaped flow channel (for fluid extraction), fluid mixing, T-shaped flow channel (for droplet generation) and straight flow channel (for transition).

[0024] (1) put it in accordance with image 3 The sequence shown is mounted on the mold assembly platform,

[0025] (2) Pour the prepared PDMS prepolymer on the combined mold surface of the assembly platform,

[0026] (3) Put the platform on the heating plate and heat it until the PDMS is cured to complete the PDMS mold.

[0027] (4) Release the cured PDMS from the mold, and perform ultrasonic cleaning on it and a glass piece of the same size at the same time, and then use an ion surface treatment instrument for surface modification.

[0028] (5) Attach the PDMS to the glass slide to complete the sealing of the microchannel.

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Abstract

The invention discloses a programmable modularized PDMS (Polydimethylsiloxane) microfluidic chip mold system and belongs to the technical field of microfluidics. A plurality of silicon chip mold module mounting areas are arranged on a mold assembling platform; a plurality of bosses are arranged in the middle of the different mounting areas; processed micro structures are arranged on silicon chips;a plurality of silicon chip mold modules with different micro structure patterns are mounted on the mold assembling platform through the bosses. By adopting the system, molds for manufacturing PDMS microfluidic chips are designed and manufactured in a modularization manner, microfluidic chip mold modules with different functions are processed by using the silicon chips, the silicon chips are further arranged and combined by using the mold assembling platform to form a microfluidic chip system mold with complex functions, and finally microfluidic chips are manufactured from PDMS through mold reversing. By adopting the system, the flexibility of the microfluidic chip processing process can be remarkably improved, the chip processing cost can be remarkably reduced, the processing process issimple to operate, and the system is applicable to microfluidic chip manufacturing with single or complex functions on the basis of PDMS materials.

Description

technical field [0001] The invention relates to a programmable modular PDMS (polydimethylsiloxane) microfluidic chip mold system, which belongs to the field of microfluidic technology. Background technique [0002] Microfluidic technology refers to the technology of controlling fluid at the micron scale. It can realize multiple detection functions on one chip, and its detection speed, accuracy and production cost are much lower than traditional methods. It is widely used in analytical chemistry, life science and medical treatment areas of diagnosis. The microfluidic chip integrates the basic operation units such as sample preparation, reaction, separation, and detection in the analysis process of biology, chemistry, and medicine into a micron-scale chip, and automatically completes the entire analysis process. The preparation materials of microfluidic chips can be divided into polymer materials, glass, paper and so on according to the application. [0003] PDMS is one of t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01L3/00
CPCB01L3/502707
Inventor 范一强刘士成张亚军
Owner BEIJING UNIV OF CHEM TECH
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