Preparation method of magnesium phosphate base bone cement modified by silicon dioxide

A magnesium phosphate-based bone and silica technology, applied in the field of biomedical repair materials, can solve the problems of high exothermic temperature, short curing time, and affecting the biocompatibility of MPC, and achieve small particle size and improved dispersion Effect

Active Publication Date: 2018-07-06
WUHAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, usually due to the extremely fast hydration reaction of MPC, the curing time is short and the exothermic temperature is high, which seriously affects the application range of magnesium phosphate cement.
[0004] Generally, high-temperature calcination is used to reduce the activity of magnesia, and the method of adding retarders such as borax is used to control the hydration reaction rate of MPC. After high-temperature sintering and prolonging the sintering time, the particle size of magnesia increases, and a large amount of oxidation remains after the reaction. Magnesium, borax and other substances are introduced as retarders, which will interfere with the body fluid environment of the human body during the material degradation process, with obvious side effects, affecting the good biocompatibility of MPC and reducing its clinical performance

Method used

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  • Preparation method of magnesium phosphate base bone cement modified by silicon dioxide

Examples

Experimental program
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Effect test

Embodiment 1

[0028] 1) Heat magnesia to 1200°C and keep it warm for 2 hours, grind the average particle size to 0.4μm, weigh 5g magnesia and disperse it in 10ml ethanol, stir to form magnesia suspension;

[0029] 2) Take another 2ml of tetraethyl orthosilicate and add it to 9ml of ethanol, stir evenly to form a tetraethyl orthosilicate solution; take another 1ml of ammonia water and add it to 10ml of ethanol, stir evenly to form a catalyst solution;

[0030] 3) Add the tetraethyl orthosilicate solution and the catalyst solution into the magnesium oxide suspension at the same time at a speed of 4 s / drop, and stir continuously with a stirrer. After stirring and reacting for 24 hours, centrifuge the reaction solution, and deionize the precipitate Wash twice with water, then wash twice with absolute ethanol, and dry at 40°C for 12 hours to prepare silica-modified magnesium oxide powder;

[0031] 4) Weigh 3g of silica-modified magnesia powder, 9g of potassium dihydrogen phosphate, and mix well ...

Embodiment 2

[0033] 1) Heat magnesia to 1400°C and keep it warm for 2 hours, grind the average particle size to 1.0 μm, weigh 5g magnesia and disperse it in 8ml ethanol, stir to form magnesia suspension;

[0034] 2) Take another 2.5ml of tetraethyl orthosilicate and add it to 10ml of ethanol, stir evenly to form a tetraethyl orthosilicate solution; take another 1ml of ammonia water and add it to 10ml of ethanol, stir evenly to form a catalyst solution;

[0035] 3) Add the tetraethyl orthosilicate solution and the catalyst solution into the magnesium oxide suspension at the same time at a speed of 3 s / drop, and stir continuously with a stirrer. After stirring and reacting for 12 hours, centrifuge the reaction solution, and deionize the precipitate Wash twice with water, then wash twice with absolute ethanol, and dry at 60°C for 12 hours to prepare silica-modified magnesium oxide powder;

[0036] 4) Weigh 3g of silica-modified magnesia powder, 8g of potassium dihydrogen phosphate, and 1g of ...

Embodiment 3

[0038] 1) Heat magnesia to 1400°C and keep it warm for 1 hour, grind the average particle size to 1.0 μm, weigh 5g magnesia and disperse it in 8ml ethanol, stir to form magnesia suspension;

[0039] 2) Take another 2.0ml of tetraethyl orthosilicate and add it to 8ml of ethanol, stir evenly to form a tetraethyl orthosilicate solution; take another 1ml of ammonia water and add it to 8ml of ethanol, stir evenly to form a catalyst solution;

[0040] 3) Add the tetraethyl orthosilicate solution and the catalyst solution to the magnesium oxide suspension at the same time at a speed of 5 s / drop, and stir continuously with a stirrer. After stirring and reacting for 12 hours, centrifuge the reaction solution, and deionize the precipitate Wash twice with water, then wash twice with absolute ethanol, and dry at 40°C for 12 hours to prepare silica-modified magnesium oxide powder;

[0041] 4) Weigh 2g of silica-modified magnesia powder, 6g of potassium dihydrogen phosphate, and 4g of calci...

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Abstract

The invention discloses magnesium phosphate base bone cement modified by silicon dioxide and a preparation method thereof. The preparation method comprises the steps that (1) magnesium oxide is subjected to calcination treatment, magnesium oxide powder is obtained through ball milling after calcination is ended, and a certain amount of magnesium oxide is uniformly dispersed in an organic solvent to form magnesium oxide turbid liquid; (2) a tetraethoxysilane and a catalyst solution are added into the turbid liquid containing magnesium oxide, the mixture is stirred, reacted, washed and dried, and magnesium oxide modified and wrapped by silicon oxide is obtained; and (3) the magnesium oxide powder modified and wrapped by silicon dioxide and phosphate powder are blended uniformly, and the magnesium phosphate base bone cement modified by silicon dioxide is obtained. The curing time can be controlled and regulated through the degree of silicon dioxide wrapping and modifying magnesium oxide,the hydration temperature when the bone cement is solidified is reduced as well, and the clinical usage performance of the magnesium base bone cement is prominently improved. The prepared magnesium phosphate base bone cement is simple in technology, lower in cost and easy to produce in an industrialized mode.

Description

technical field [0001] The invention relates to the field of biomedical repair materials, in particular to a silica-modified magnesium-based bone filling repair material and a method for preparing the material. technical background [0002] Magnesium Phosphate-based Bone Cement (MPC) is a new type of biological gel material prepared by burning magnesium oxide, phosphate and solid phase blending solution in a certain proportion. It has the characteristics of fast setting and high early strength, and can self-cure in the physiological environment of the human body, and can form a high-strength interface bond with bone tissue. The hydration product is a phosphate biomineral, and the hydration product has good biocompatibility sex, no toxic side effects. [0003] The essence of the hydration reaction of MPC is an exothermic reaction based on acid-base neutralization reaction. The reaction speed is fast and the heat release is large. Materials, curing time controlled by hydrati...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C04B12/02
CPCC04B12/02
Inventor 戴红莲王浩余素春赵雅楠
Owner WUHAN UNIV OF TECH
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