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Medicine composition containing cefpodoxime proxetil

A technology of cefpodoxime axetil and its composition, which is applied in the field of pharmaceutical compositions containing cefpodoxime axetil and its preparation, and can solve the problems of increased preparation cost, gelation, and higher requirements for fillers, etc.

Inactive Publication Date: 2018-07-10
天津双硕医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Wetting agent water or alcohol needs to be added in the process of wet granulation, which is easy to cause gelation and serious caking phenomenon
The effect of powder direct compression is poor, so it is generally necessary to add a large amount of fillers, and the requirements for fillers are high, which greatly increases the preparation cost and the drug dissolution is not good
Dry granulation can avoid the gelation problem of wet granulation, and the obtained granules can be used to prepare tablets, capsules or granules. falling problem

Method used

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  • Medicine composition containing cefpodoxime proxetil
  • Medicine composition containing cefpodoxime proxetil
  • Medicine composition containing cefpodoxime proxetil

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0128] Embodiment 1 Cefpodoxime axetil film-coated tablet preparation (unit: g)

[0129] prescription:

[0130]

[0131] The preparation process is as follows:

[0132] 1) Get cefpodoxime axetil raw material medicine and pulverize, cross 200 mesh sieves, set aside;

[0133] 2) Take the filler mannitol, 50% of the prescription amount of the disintegrating agent low-substituted hydroxypropyl cellulose, sieve, and set aside;

[0134] 3) Take the prescribed amount of cefpodoxime axetil, filler mannitol and 50% of the prescribed amount of disintegrant low-substituted hydroxypropyl cellulose, mix evenly, dry granulate, and granulate to obtain drug-loaded cefpodoxime axetil granules;

[0135] 4) Take the drug-loaded cefpodoxime axetil granules, the remaining 50% of the prescription amount of the disintegrant low-substituted hydroxypropyl cellulose, the gel inhibitor meglumine, the glidant colloidal silicon dioxide lubricant magnesium stearate, and mix Uniformly, obtain the phar...

Embodiment 2

[0138] Embodiment 2 cefpodoxime axetil hard capsule preparation (unit: g)

[0139] prescription:

[0140]

[0141] The preparation process is as follows:

[0142] 1) Get cefpodoxime axetil raw material medicine and pulverize, cross 200 mesh sieves, set aside;

[0143] 2) Take the filler mannitol, 50% of the prescription amount of the disintegrating agent low-substituted hydroxypropyl cellulose, sieve, and set aside;

[0144] 3) Take the prescribed amount of cefpodoxime axetil, filler mannitol and 50% of the prescribed amount of disintegrant low-substituted hydroxypropyl cellulose, mix evenly, dry granulate, and granulate to obtain drug-loaded cefpodoxime axetil granules;

[0145] 4) Take the drug-loaded cefpodoxime axetil granules, the remaining 50% of the prescription amount of the disintegrant low-substituted hydroxypropyl cellulose, the gel inhibitor meglumine, the glidant colloidal silicon dioxide lubricant magnesium stearate, and mix Uniformly, obtain the pharmaceut...

Embodiment 3

[0147] Example 3 Preparation of Cefpodoxime Proxetil Granules (Unit: g)

[0148] prescription:

[0149]

[0150] The preparation process is as follows:

[0151] 1) get the cefpodoxime axetil raw material drug pulverization, cross 200 mesh sieves, set aside;

[0152] 2) Take the filler mannitol, 50% of the prescription amount of the disintegrating agent low-substituted hydroxypropyl cellulose, sieve, and set aside;

[0153] 3) Take the prescribed amount of cefpodoxime axetil, filler mannitol and 50% of the prescribed amount of disintegrant low-substituted hydroxypropyl cellulose, mix evenly, dry granulate, and granulate to obtain drug-loaded cefpodoxime axetil granules;

[0154] 4) Take the drug-loaded cefpodoxime axetil granules, the remaining 50% of the prescription amount of disintegrant low-substituted hydroxypropyl cellulose, gel inhibitor meglumine, glidant colloidal silicon dioxide, and flavoring agent sodium glutamate , a lubricant magnesium stearate, mixed unif...

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Abstract

The invention discloses a medicine composition containing cefpodoxime proxetil. Meglumine is added into the composition to be used as a gelatin inhibitor; the gelation phenomenon of the solid preparation in an aqueous solution can be effectively inhibited; the dissolution-out performance of a solid preparation is effectively improved; the bioavailability is further improved. A flavoring agent of sodium glutamate is added in the composition to achieve the cooperated effect with meglumine, the problem of bitter taste of the particle preparation is solved. Through a dry process granulation process, the introduction of adverse factors such as moisture and high temperature is avoided; a preparation recipe is matched; the problems of hydrolysis or oxidization degradation of ester bonds, amido bonds, lactam bonds and primary amine groups in raw medicine molecules is solved. Experiments prove that the effect is good.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to a pharmaceutical composition containing cefpodoxime axetil and a preparation method thereof. Background technique [0002] Antimicrobial infection drugs are a large class of drugs with the second largest sales in the global pharmaceutical market today, and β-lactam antibiotics are the most clinically used, most widely used, most varieties, best curative effect and highest evaluation class Antibiotics occupy an important position in anti-infective drugs, accounting for 58.7% of the total sales of antibiotics in the world. Among them, cephalosporin series products account for about 70%. It can be seen that in the pharmaceutical market, cephalosporins occupy an important position in β-lactam antibiotics and even anti-infective drugs. [0003] Among various cephalosporins, oral cephalosporins are popular among medical staff and patients because of their convenience and...

Claims

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Application Information

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IPC IPC(8): A61K9/36A61K9/48A61K9/16A61K31/546A61K47/38A61K47/26A61K47/18A61K47/04A61K47/12A61P31/04
CPCA61K31/546A61K9/1611A61K9/1617A61K9/1623A61K9/1652A61K9/2009A61K9/2013A61K9/2018A61K9/2054A61K9/2866A61K9/485A61K9/4858A61K9/4866
Inventor 不公告发明人
Owner 天津双硕医药科技有限公司
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