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Preparation method, products, and applications of bismuth carbonate oxide nano-material

A technology of bismuth oxycarbonate nano and bismuth oxycarbonate, which is applied in the direction of medical preparations containing active ingredients, radiation-sensitizing materials, wave energy or particle radiation treatment materials, etc., which can solve the problem of large X-ray attenuation coefficient and limited clinical application , high cost and other issues, to achieve good load performance, improve the killing effect, and the effect of large specific surface area

Active Publication Date: 2018-07-13
ZHEJIANG UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The X-ray attenuation coefficient of gold nanoparticles is large, but the high cost limits its further clinical application

Method used

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  • Preparation method, products, and applications of bismuth carbonate oxide nano-material
  • Preparation method, products, and applications of bismuth carbonate oxide nano-material
  • Preparation method, products, and applications of bismuth carbonate oxide nano-material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] Embodiment 1: Preparation of bismuth oxycarbonate nanodots

[0058] Disperse 40mg of bismuth acetate, 0.2g of cetylamine and 2ml of oleic acid in 8ml of octadecene, heat and stir at 100°C for 30min to obtain small-sized bismuth oxycarbonate nanodots.

[0059] The morphology of small-sized bismuth oxycarbonate nanodots was characterized by transmission electron microscopy, as shown in the attached figure 1 As shown, the particle size is 1-2nm.

Embodiment 2

[0060] Embodiment 2: Preparation of bismuth oxycarbonate nanodots

[0061] Disperse 80mg of bismuth acetate, 0.4g of hexadecylamine and 4ml of oleic acid in 12ml of octadecene, heat and stir at 90°C for 2 hours to obtain small-sized bismuth oxycarbonate nanodots with a particle size of 1-2nm.

Embodiment 3

[0062] Embodiment 3: Preparation of bismuth oxycarbonate nanodots

[0063] Disperse 100mg of bismuth acetate, 0.6g of hexadecylamine and 6ml of oleic acid in 20ml of octadecene, heat and stir at 100°C for 1 hour to obtain small-sized bismuth oxycarbonate nanodots with a particle size of 1-2nm.

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Abstract

The invention relates to a preparation method, products, and applications of a bismuth carbonate oxide nano-material. The bismuth carbonate oxide nano-material is capable of realizing specific enrichment in tumor, so that tumor CT imaging and treatment can be realized; and the bismuth carbonate oxide nano-material can be excreted to the outside of the body through the kidney, so that the biosecurity is high.

Description

technical field [0001] The invention relates to the field of preparation of bismuth oxycarbonate nanomaterials, in particular to a preparation method of bismuth oxycarbonate nanomaterials and its products and applications. Background technique [0002] X-ray computed tomography (CT) is a technology that uses precisely collimated X-ray beams and highly sensitive detectors to perform multiple and rapid cross-sectional scans around a certain part of the human body to obtain disease information. Its scanning speed is fast and the image is relatively clear, so it is often used to diagnose many diseases. At the same time, CT imaging has many advantages, such as high density resolution, quantitative analysis and various image processing by computer. [0003] At present, the CT contrast agent commonly used clinically is iodine molecule, such as iohexol. However, iodine molecules are easily cleared by the kidneys, so their circulation time in the body is short. In addition, their c...

Claims

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Application Information

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IPC IPC(8): A61K49/04A61K41/00A61K33/24A61K47/02A61K9/00A61P35/00
CPCA61K9/0092A61K33/245A61K41/0038A61K47/02A61K49/04
Inventor 凌代舜李方园胡希
Owner ZHEJIANG UNIV
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