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A kind of anti-collapse and high-strength composite calcium phosphate bone cement and its preparation method and application

A calcium phosphate bone cement, high-strength technology, used in prosthesis, tissue regeneration, medical science and other directions, can solve the problems of self-curing or collapse, and achieve good application prospects, good clinical application effects, and prolong the effect of curing time.

Active Publication Date: 2020-12-11
JINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to overcome the shortcomings and deficiencies of the prior art calcium phosphate bone cement that cannot be self-cured or collapsed due to the immersion and scouring of body fluids before self-curing during the injection process, the primary purpose of the present invention is to provide an anti-collapse and high-strength bone cement. Composite Calcium Phosphate Bone Cement

Method used

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  • A kind of anti-collapse and high-strength composite calcium phosphate bone cement and its preparation method and application
  • A kind of anti-collapse and high-strength composite calcium phosphate bone cement and its preparation method and application
  • A kind of anti-collapse and high-strength composite calcium phosphate bone cement and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] 1. Preparation of calcium phosphate cement

[0043] Dissolve Dopa-CS (grafting rate 10%) in 0.1M citric acid solution to make 0.5% Dopa-CS solution, then mix Dopa-CS solution with 1g Calcium phosphate bone cement powder (α-tricalcium phosphate-calcium hydrogen phosphate-calcium carbonate) was uniformly mixed, reconciled into a paste, injected into the mold and tested.

[0044] 2. Physical and chemical performance testing

[0045] The physical and chemical properties of the bone cement prepared in step 1 and those without Dopa-CS were tested.

[0046] (1) Curing time test

[0047] The cure time test was performed according to the American Society for Testing and Materials standard ASTM C190-03. The weight of the indenter of the Vicat instrument used is 300±0.5g, and the diameter of the needle is 1±0.05mm. The test steps are as follows: Fill the above-mentioned blended paste into a φ8mm×12mm cylindrical mold to form it, and put it in a constant temperature and humidit...

Embodiment 2

[0058] Dissolve Dopa-CS (grafting rate 7%) in 0.1M citric acid solution to make 1% Dopa-CS solution, then mix Dopa-CS solution with 1g Calcium phosphate bone cement powder (α-tricalcium phosphate-calcium dihydrogen phosphate-calcium carbonate) was evenly mixed, reconciled into a paste, injected into the mold and tested. The detection method and steps are the same as in Example 1.

[0059] The physical and chemical properties of the anti-collapse and high-strength calcium phosphate bone cement containing Dopa-CS prepared in this example and ordinary α-tricalcium phosphate-calcium dihydrogen phosphate-calcium carbonate bone cement are shown in Table 2:

[0060] Table 2 physical and chemical properties

[0061]

[0062] Compared with ordinary calcium phosphate bone cement, the anti-collapse and high-strength calcium phosphate bone cement containing Dopa-CS prepared in this example has an anti-collapse coefficient of 81±3%, and the anti-collapse time is also increased to more ...

Embodiment 3

[0064] Dissolve Dopa-CS (grafting rate 10%) in 0.1M citric acid solution to make 2% Dopa-CS solution, then mix Dopa-CS solution with 1g Calcium phosphate bone cement powder (α-tricalcium phosphate-calcium dihydrogen phosphate-calcium carbonate) was evenly mixed, reconciled into a paste, injected into the mold and tested. The detection method and steps are the same as in Example 1.

[0065] The physical and chemical properties of the anti-collapse and high-strength calcium phosphate bone cement containing Dopa-CS prepared in this example and ordinary α-tricalcium phosphate-calcium dihydrogen phosphate-calcium carbonate bone cement are shown in Table 3:

[0066] Table 3 physical and chemical properties

[0067]

[0068] Compared with ordinary calcium phosphate bone cement, the anti-collapse and high-strength calcium phosphate bone cement containing Dopa-CS prepared in this example has an anti-collapse coefficient of 85±4%, and the anti-collapse time is also increased to more...

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Abstract

The invention belongs to the field of bone injury repair medical materials, and discloses scattering-resistant and high-strength composite calcium phosphate bone cement, a method for preparing the same and application of the scattering-resistant and high-strength composite calcium phosphate bone cement. The scattering-resistant and high-strength composite calcium phosphate bone cement comprises calcium phosphate bone cement and hydroxypropyl benzoic acid-g-chitosan. The weight of the hydroxypropyl benzoic acid-g-chitosan is 0.2-3% of the weight of the calcium phosphate bone cement, and 3, 4-dihydroxyl phenylpropionic acid or 3, 4-dihydroxy phenyl acetic acid and chitosan are coupled with each other to obtain the hydroxypropyl benzoic acid-g-chitosan. The scattering-resistant and high-strength composite calcium phosphate bone cement, the method and the application have the advantages that the scattering-resistant and high-strength composite calcium phosphate bone cement is excellent inbiocompatibility as compared with ordinary calcium phosphate bone cement, the strength, the scattering-resistant performance and the biocompatibility of the calcium phosphate bone cement can be improved by the aid of the excellent adhesion properties of Dopa-CS (dihydroxyphenylalanine-chitosan) and the excellent biocompatibility of the CS, the original solidification characteristics of the calciumphosphate bone cement further can be kept, and the solidification time of the calcium phosphate bone cement rarely can be affected; the scattering-resistant performance and the compressive strength can be obviously improved, and the scattering-resistant and high-strength composite calcium phosphate bone cement can be applied to the field of bone injury repair.

Description

technical field [0001] The invention belongs to the field of medical materials for repairing bone damage, and in particular relates to an anti-collapse and high-strength composite calcium phosphate bone cement and its preparation method and application. Background technique [0002] Repairing bone defect with artificial bone is a brand-new treatment mode and one of the hot issues in current medical research. Calcium phosphate bone cement (CPC) is composed of one or more kinds of calcium phosphate solid phase powder and solidification liquid, which can be cured by itself under physiological conditions. The organization is similar. More importantly, this material can be easily injected and adapted to the shape of the defect, and can be gradually degraded after being implanted in the bone defect, avoiding the pain of secondary surgery, which makes it have significant advantages and broad clinical application in bone repair. market. However, this material system has the disad...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/12A61L27/20A61L27/50
CPCA61L27/12A61L27/20A61L27/50A61L2430/02C08L5/08
Inventor 丁珊刘树英李双丽刘学斌周长忍
Owner JINAN UNIVERSITY
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