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Bone repairing material for injection plastic surgery and preparation method

A technology of bone repair and bone powder, which is applied in the fields of medical formula, medical science, prosthesis, etc., can solve the problems of difficult closure of bone cracks and difficulty of bone repair and healing, achieve good compatible growth function, promote healing and strengthening, good affinity effect

Inactive Publication Date: 2018-07-24
CHENDU NEW KELI CHEM SCI CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] Aiming at the defects that the existing bone repair materials are difficult to repair and heal, and the bone cracks are hard to close due to early calcification, the present invention proposes a bone repair material for injection plastic surgery and its preparation method

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] The bone repair material for injection plastic surgery was prepared by the following method:

[0034] a. Grinding of bone meal: select clean bone meal, airflow crush it under the condition of liquid nitrogen freezing, and use high-speed airflow to impact and refine it to obtain nano-scale bone meal for future use.

[0035] b. Activation of nano-scale bone powder: mix nano-scale bone powder with 10wt% citric acid solution, stir for 120 minutes, and let it stand for 3 days; soak nano-scale bone powder in citric acid solution to soften, remove part of the calcium, and wash with salt water , dried to obtain activated bone powder, the activated bone powder has activity and good micropores; wherein, the weight of nano-bone powder to the volume ratio of citric acid solution is 1g: 1mL.

[0036] c. Ultrasonic dispersion: disperse polylactic acid nanofibers, sea cucumber glue, nanocellulose fibers, hyaluronic acid, and recombinant bovine basic fibroblast growth factor in glyceri...

Embodiment 2

[0038] The bone repair material for injection plastic surgery was prepared by the following method:

[0039] a. Grinding of bone meal: select clean bone meal, airflow crush it under the condition of liquid nitrogen freezing, and use high-speed airflow to impact and refine it to obtain nano-scale bone meal for future use.

[0040] b. Activation of nano-scale bone powder: mix nano-scale bone powder with 20wt% citric acid solution, stir for 60 minutes, and let it stand for 1 day; soak nano-scale bone powder in citric acid solution to soften, remove part of the calcium, and wash with salt water , dried to obtain activated bone powder, the activated bone powder has activity and good micropores; wherein, the weight of nano-bone powder to the volume ratio of citric acid solution is 1g:5mL.

[0041] c. Ultrasonic dispersion: Polylactic acid nanofibers, sea cucumber glue, nanocellulose fibers, hyaluronic acid, and recombinant bovine basic fibroblast growth factor are dispersed in glyce...

Embodiment 3

[0043] The bone repair material for injection plastic surgery was prepared by the following method:

[0044] a. Grinding of bone meal: select clean bone meal, airflow crush it under the condition of liquid nitrogen freezing, and use high-speed airflow to impact and refine it to obtain nano-scale bone meal for future use.

[0045] b. Activation of nano-scale bone powder: mix nano-scale bone powder with 12wt% citric acid solution, stir for 70 minutes, and let it stand for 2 days; soak nano-scale bone powder in citric acid solution to soften, remove part of the calcium, and wash with salt water , dried to obtain activated bone powder, the activated bone powder has activity and good micropores; wherein, the weight of nano-bone powder and the volume ratio of citric acid solution are 1g:2mL.

[0046] c. Ultrasonic dispersion: Polylactic acid nanofibers, sea cucumber glue, nanocellulose fibers, hyaluronic acid, and recombinant bovine basic fibroblast growth factor are dispersed in gl...

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PUM

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Abstract

The invention relates to a bone repairing material for injection plastic surgery and a preparation method and belongs to the technical field of bone repairing materials. Aiming at the defects of an existing bone repairing material that the bone repairing and healing difficulty is great, bone cracks are calcified in advance and are difficult to close, the invention provides the bone repairing material for the injection plastic surgery and the preparation method. According to the method provided by the invention, pre-decalcification and activation are carried out on bone meal and removing part of calcium, so as to enable the bone meal to have activity and good micro-pores and enable the bone meal and bone blood to have a good compatible growth function; bone cells and blood vessels are induced to grow through an auxiliary recombinant bovine alkaline fibroblast growth factor, so as to enable the bone blood to rapidly grow to form a whole body in the activated and modified micro-pores; meanwhile, polylactic acid nano-fibers and nano cellulose fibers are used as auxiliary enhanced bonding materials to promote healing and strengthening; sea cucumber glue and hyaluronic acid are used as biomass filling materials for filling defect tissues of bone injuries and have better affinity on human bodies.

Description

technical field [0001] The invention relates to a bone repair material for injection plastic surgery and a preparation method thereof, belonging to the technical field of tissue repair materials. Background technique [0002] The repair and reconstruction of bone defects has always been an important research direction in orthopedics and plastic surgery. Bone repair material is a bone mold introduced in the process of assisting human bone reconstruction and repair. By implanting bone repair material in the human body, it can help people better reconstruct bone shape and structure. The application in is very extensive. Traditional bone repair materials generally use alloy implants to promote bone repair. The operation process is painful and the repair effect is not satisfactory. Multiple operations are required and sequelae will be left. [0003] At present, bone repair materials are developing toward biocompatibility, which not only has excellent biocompatibility, but also ...

Claims

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Application Information

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IPC IPC(8): A61L27/36A61L27/20A61L27/18A61L27/50A61L27/54
CPCA61L27/3608A61L27/18A61L27/20A61L27/365A61L27/3687A61L27/50A61L27/54A61L2300/414A61L2400/06A61L2430/02C08L5/08C08L1/02C08L67/04
Inventor 陈庆曾军堂
Owner CHENDU NEW KELI CHEM SCI CO LTD