Method for extracting hesperidin from fructus aurantii immaturus according to continuous countercurrent method and extracted hesperidin

A countercurrent extraction and hesperidin technology, applied in the field of hesperidin, can solve the problems of poor product quality, complicated operation, low extraction rate, etc., and achieve the effects of large concentration difference, high extraction efficiency, and reduced extraction time.

Active Publication Date: 2018-08-10
CHONGQING HOLLEY PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The first object of the present invention is to provide a continuous countercurrent method for extracting hesperidin from Fructus Citrus Fructus Auranti

Method used

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  • Method for extracting hesperidin from fructus aurantii immaturus according to continuous countercurrent method and extracted hesperidin

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Embodiment 1

[0074] The present embodiment provides a kind of method extracting hesperidin from Fructus Aurantii Fructus Aurantii, comprising the following steps:

[0075] (a) get 300kg Citrus aurantium raw material, pulverize, cross 20 mesh sieves;

[0076] (b) methanol sodium hydroxide solution is configured in the liquid distribution tank, wherein the concentration of methanol is 50%, and the mass fraction of sodium hydroxide in the solution is 3%;

[0077] (c) the Fructus Fructus Aurantii raw material and methanol sodium hydroxide solution are infiltrated in a continuous infiltrator with an ultrasonic generator in a ratio of 1:0.5 to liquid;

[0078] (d) Feed the infiltrated Fructus Fructus Citrus Fructus from the feed port of the continuous countercurrent machine. The continuous countercurrent extractor is a single-stage extractor with a length of 10 meters. Solvent, by adjusting the speed control of the screw propeller, the raw material stays in the extractor for 3 hours for the ext...

Embodiment 2

[0083] The present embodiment provides a kind of method extracting hesperidin from Fructus Aurantii Fructus Aurantii, comprising the following steps:

[0084] (a) get 300kg Fructus Aurantium raw material, pulverize, cross 10 mesh sieves;

[0085] (b) Alcohol potassium hydroxide solution is configured in the liquid distribution tank, wherein the ethanol concentration is 90%, and the mass fraction of potassium hydroxide in the solution is 1%;

[0086] (c) Fructus Fructus Aurantii raw material and ethanol potassium hydroxide solution are infiltrated in a continuous infiltrator with an ultrasonic generator at a ratio of 1:1 to liquid;

[0087] (d) Feed the infiltrated Citrus aurantium from the feed port of the continuous countercurrent extractor, the continuous countercurrent extractor is a single-stage extractor with a length of 10 meters, and extract from the end of the continuous countercurrent device according to the ratio of material to liquid at 1:10 Solvent, by adjusting t...

Embodiment 3

[0092] The present embodiment provides a kind of method extracting hesperidin from Fructus Aurantii Fructus Aurantii, comprising the following steps:

[0093] (a) get 300kg Citrus aurantium raw material, pulverize, cross 15 mesh sieves;

[0094] (b) methanol sodium hydroxide solution is configured in the liquid distribution tank, wherein the concentration of methanol is 70%, and the mass fraction of sodium hydroxide in the solution is 2%;

[0095] (c) the Fructus Fructus Aurantii raw material and the methanolic sodium hydroxide solution are infiltrated in a continuous infiltrator with an ultrasonic generator in a material-to-liquid ratio of 1:0.8;

[0096] (d) Feed the infiltrated Fructus Fructus Citrus Fructus from the feed port of the continuous countercurrent extraction machine, the continuous countercurrent extraction machine is a single-stage extraction machine with a length of 10 meters, and extract from the tail end of the continuous countercurrent device according to t...

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Abstract

The invention relates to the technical field of plant extraction and provides a method for extracting hesperidin from fructus aurantii immaturus according to a continuous countercurrent method and theextracted hesperidin. The method for extracting hesperidin from fructus aurantii immaturus includes: providing fructus aurantii immaturus infiltrated by alkaline alcoholic solution, mixing with alkaline alcoholic solution, performing continuous countercurrent extraction, and crystallizing extract liquid obtained in continuous countercurrent extraction to obtain hesperidin. The method is high in extraction efficiency, extraction time can be effectively shortened, and accordingly productivity is improved; in addition, extraction solvent quantity can be effectively decreased, and accordingly alcohol consumption and alcohol recovery energy consumption are sharply reduced, and cost reduction is realized; moreover, the extract liquid is high in product concentration, concentration difference ofextract liquid in different time periods is avoided, and stable product quality is realized after crystallization. The hesperidin is obtained by application of the method for extracting hesperidin from fructus aurantii immaturus. The hesperidin has advantages of high purity and quality stability and is high in market value and worthy of popularization and application.

Description

technical field [0001] The invention relates to the technical field of plant extraction, in particular to a method for extracting hesperidin from Citrus aurantium by a continuous countercurrent method and the extracted hesperidin. Background technique [0002] Citrus aurantium is the fallen fruit of young citrus fruits, and is the main raw material for the production of hesperidin. The annual production of hesperidin in my country exceeds 3,000 tons. Hesperidin has the functions of maintaining osmotic pressure, enhancing capillary toughness, shortening bleeding time, and lowering cholesterol. It is clinically used as an adjuvant treatment for cardiovascular system diseases. Raw material of diosmin. Common extraction methods for hesperidin include solvent extraction, alkali extraction and acid precipitation, carbon powder adsorption, and ion exchange. Among them, the alkali extraction and acid precipitation method is simple to operate, low in cost, and has a high extraction ...

Claims

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Application Information

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IPC IPC(8): C07H17/07C07H1/08
CPCC07H1/08C07H17/07
Inventor 石磊饶洁王余兵
Owner CHONGQING HOLLEY PHARMA
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