Subcutaneous medicine controllable release biological needle and preparation method thereof

A drug and biological technology, applied in the direction of drug combination, drug delivery, pharmaceutical formulation, etc., can solve the problems of time-consuming and labor-intensive, and achieve the effect of low price, small size, and controlled drug release

Inactive Publication Date: 2018-08-31
BEIJING UNIV OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these implants require professionals to perform surgical operations, and some drug dosage forms have to be removed by surgery after a period of time, which is time-consuming and labor-intensive.

Method used

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  • Subcutaneous medicine controllable release biological needle and preparation method thereof
  • Subcutaneous medicine controllable release biological needle and preparation method thereof
  • Subcutaneous medicine controllable release biological needle and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Example 1 The preparation of a biological needle with a height of 3mm and a bottom diameter of 1.2mm

[0031] Proceed as follows:

[0032] (1) Preparation of biological needle template: Prepare a stainless steel needle with a tip by electric grinding and polishing, and place the steel needle vertically in a horizontal container so that the steel needle is 3 mm higher than the bottom of the container, and the diameter of the plane in contact with the bottom of the container is 1.2mm. Weigh 100g of polydimethylsiloxane and 10g of curing agent to mix, stir evenly and remove the air bubbles under vacuum conditions, then pour the liquid polydimethylsiloxane containing curing agent with the removed air bubbles on a stainless steel needle In the container, place it in an oven at 60°C for 6 hours and then release the mold to obtain a polydimethylsiloxane template with a depth of 3 mm and a bottom diameter of 1.2 mm, which is packaged for use;

[0033] (2) Preparation of solut...

Embodiment 2

[0035] Embodiment 2 in vitro skin penetration test

[0036] Proceed as follows:

[0037] Disinfect the flat fresh dehaired pigskin, take the dried biological needle and install it on a self-made hand-held drag-and-drop device, and align the needle point of the biological needle with the surface of the pigskin and insert it vertically. Use an optical microscope to observe the biological needles and pigskin before and after piercing the pigskin, and slice the pigskin along the pinholes to observe the tissue sections of the pigskin.

[0038] It can be observed under an optical microscope that the height of the biological needle installed on the drag-and-drop device is 3mm and the bottom diameter is 1.2mm before being pierced into the pigskin. After piercing into the pigskin, only a little bit of polymer remained on the dropper with the bioneedle installed, indicating that the entire bioneedle was completely pierced into the pigskin. In addition, there is a clear pinhole on the su...

Embodiment 3

[0039] Embodiment 3 in vitro subcutaneous dissolution test

[0040] Proceed as follows:

[0041] At room temperature, take a number of completely dry biological needles and install them on the automatic dynamometer in 5 groups. Use a constant force of 10N to pierce the biological needles into fresh hair-free pigskin and stay for 2, 5, 10, 20 and 30 minutes respectively. The array was removed, and the shape changes of the biological needles after staying subcutaneously for different periods of time were observed under a microscope. The results showed that 2 minutes after the biological needle was inserted into the skin, the tip of the needle began to dissolve, exposing the encapsulated drug microspheres. After 10 minutes of subcutaneous insertion, it can be seen that the needle tip of the bioneedle is completely dissolved in the subcutaneous tissue, and most of the drug microspheres are released into the subcutaneous tissue. After 20 minutes, all the drug microspheres are rel...

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Abstract

The invention relates to a subcutaneous medicine controllable release biological needle and a preparation method thereof. By adopting the biological needle, a medicine can be controlled to being released subcutaneously with slight pain, and in addition, the medicine can be administrated by a patient self. The biological needle comprises a needle shell part and a needle core part, wherein the needle shell part is made of a soluble polymer material; the needle core part is composed of accumulated medicine carrier microspheres. The biological needle is sufficient in mechanical property to puncture into skin and is rapidly dissolved to release medicine carrier microspheres carried by the biological needle, and the medicine carrier microspheres carried by the biological needle can be degraded subcutaneously to release the medicine. By adopting the subcutaneous medicine controllable release biological needle provided by the invention, a liver first-pass effect caused by an orally taken slowrelease tablet can be avoided, in addition, the defect that a subcutaneous implanting agent needs to be operated by a medical operator manually can be avoided, and both medicinal effects and economy can be greatly improved.

Description

technical field [0001] The invention belongs to the technical field of subcutaneous drug controlled release, and in particular relates to a preparation method of a bioneedle for controlled subcutaneous drug release that can be self-administered by patients. Background technique [0002] Controlled drug release is to use natural or synthetic materials as the carrier or medium of the drug, make a certain dosage form, control the release rate of the drug in the living body, and make the drug release at a certain rate within the required time range according to the designed dose. It is slowly released in the body to achieve the purpose of treating a certain disease. Compared with conventional drug release, it has incomparable advantages: [0003] 1) Can use drugs very effectively. Because the controlled release can control the drug concentration to be constant within the effective range for a long time, the utilization rate of the drug can reach 70%-90%, while the utilization ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K31/4985A61K31/567A61K31/7048A61K9/50A61K47/34A61P5/32A61P33/10
CPCA61K9/0021A61K9/5031A61K31/4985A61K31/567A61K31/7048A61P5/32A61P33/10
Inventor 郭新东陈博智
Owner BEIJING UNIV OF CHEM TECH
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