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Electrochemiluminescent reagent prepared from a macrocyclic compound and its application

A macrocyclic compound, electrochemical technology, applied in the field of electrochemiluminescence, can solve the problems of long time consumption, high analysis cost, difficult sample preparation, etc., and achieve the effect of short time consumption and simple operation.

Active Publication Date: 2020-10-23
GUIZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, chromatography is usually used to detect fused ring aromatic hydrocarbons, but its sample preparation is difficult, time-consuming, and the analysis cost is high

Method used

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  • Electrochemiluminescent reagent prepared from a macrocyclic compound and its application
  • Electrochemiluminescent reagent prepared from a macrocyclic compound and its application
  • Electrochemiluminescent reagent prepared from a macrocyclic compound and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] A macrocyclic compound, the chemical formula of the macrocyclic compound is C 60 h 60 N 12 o 6 , whose structural formula is:

[0032]

[0033] The synthetic method of described macrocyclic compound is synthesized according to the following steps:

[0034] (1) 2-hydroxybenzimidazole (2g, 0.015mol), tetrabutylammonium bromide (0.24g, 0.75mmol), toluene 50mL, 40% sodium hydroxide solution 20mL and iodomethane (2mL, 0.032mol) , heated at 60-80°C for 19 hours to obtain product A;

[0035] (2) Mix product A, hydrochloric acid solution and formic acid to obtain product B;

[0036] (3) adding concentration to product B is 40% formaldehyde solution, stir evenly, obtain product C;

[0037] (4) Product C was stirred at room temperature for 5 hours, a white precipitate appeared, and product D was obtained;

[0038] (5) Product D was filtered by suction, washed with methanol and dichloromethane successively, and dried to obtain a white solid.

[0039] Described hydrochlo...

Embodiment 2

[0045] (1) Prepare 1.0×10 with acetonitrile -5 mol / l, 1.0×10 -6 mol / l…1.0×10 -14 mol / l, 1.0×10 - 15 mol / l equal concentration of the above-mentioned various condensed ring aromatic hydrocarbon solutions;

[0046] (2) Stir the glassy carbon electrode modified with the macrocyclic compound with the condensed ring aromatic hydrocarbons in the above step (1) for 25 minutes at room temperature, dry and set aside;

[0047] (3) Measure the electrode to be used in the above step (2) in an electrochemiluminescence tester;

[0048] (4) Graphing the data completed by the measurement, the results are shown in figure 2 ,in figure 2 (b), it was found that the electrochemiluminescence of the macrocyclic compound was not completely quenched by the 9.10-triphenylene triphenylene guest, and all other guests were completely quenched.

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Abstract

The invention discloses an electrochemical luminescent reagent prepared from a macrocyclic compound and application thereof. The electrochemical luminescent reagent prepared from the macrocyclic compound is simple in operation and short in consumed time; the application of the electrochemical luminescent reagent is capable of detecting polycyclic aromatic hydrocarbons (naphthalene, pyrene, anthracene, phenanthrene, perylene and 9,10-benzophenanthrene triphenylene), and the application is different from current frequently-used chromatography for detecting the polycyclic aromatic hydrocarbons; the macrocyclic compound has a cavity structure and is different from frequently-used electrochemical luminescent substances (such as luminol and tris(bipyridine) ruthenium), a new electrochemical luminescent substance is developed, and a new development direction is provided for research and application of macrocyclic host-guest chemical compounds and electrochemical luminescence.

Description

technical field [0001] The invention relates to the field of electrochemiluminescence, in particular to an electrochemiluminescence reagent prepared from a macrocyclic compound and its application. Background technique [0002] Electrochemiluminescence (ECL), also known as electrochemiluminescence, is the product of the combination of chemiluminescence and electrochemical methods. A luminescent phenomenon produced by a further reaction with other substances; in addition to the advantages of high sensitivity, wide linear range, and simple equipment of chemiluminescence analysis, electrochemiluminescence analysis can also overcome chemiluminescence analysis. The shortcomings in the method, such as chemiluminescent reagents are not easy to store or unstable under specific conditions, it is difficult to achieve time and space control, making it difficult to reuse chemiluminescent reagents, and the reproducibility caused by uneven mixing of solutions Relatively poor and other sh...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/76G01N27/30
CPCG01N21/76G01N27/308
Inventor 丛航黎海玲王方
Owner GUIZHOU UNIV