A kind of chitosan hydrogel preparation and preparation method of dihydromyricetin

A technology of dihydromyricetin and gel preparation, which is applied in the directions of non-active ingredient medical preparations, medical preparations containing active ingredients, pharmaceutical formulas, etc., to achieve improved tumor-inhibiting ability, good biocompatibility, and release effect Good results
CN108514546BActive Publication Date: 2020-09-29海生健康科技(青岛)有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
海生健康科技(青岛)有限公司
Publication Date
2020-09-29

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Abstract

The invention discloses a chitosan hydrogel preparation of dihydromyricetin. In the preparation process of the chitosan hydrogel preparation, malic acid is used as a crosslinking agent for forming chitosan gel, and Tween-80 is introduced as a gel structure control agent. The chitosan hydrogel prepared in the invention is a good sustained release preparation, has a good release effect on the drug dihydromyricetin, improves the ability of the drug to inhibit tumor cells, and has certain targeting to the tumor cells. The drug carrier of the chitosan hydrogel preparation has good biocompatibility,and is of great significance to develop new antitumor drugs.
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Description

technical field

[0001] The invention relates to the field of pharmaceutical preparations, in particular to a dihydromyricetin-chitosan hydrogel preparation with malic acid as a crosslinking agent and Tween-80 as a gel structure control agent and a preparation method thereof. Background technique

[0002] As we all know, the mortality rate of cancer remains high in the world. At present, the research on its complex pathogenesis has not yet drawn a clear conclusion. Cancer cells originate from the mutation of normal cells in the body. The mutated cells are no longer regulated by the normal apoptosis program and begin to proliferate indefinitely, becoming tumor cells. Cancer is a hot research field for medical workers, and many different types of drugs have been launched for different treatment ideas. Chemotherapy, as the mainstay of cancer treatment, brings hope of cure to many patients. At the same time, anticancer drugs are also a double-edged sword, which has an irreplac...

Claims

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