Pharmaceutical composition with analgesic function

A composition and pharmacy technology, applied in the directions of drug combinations, medical preparations containing active ingredients, antipyretics, etc., can solve the problems of reducing pain sensation, large side effects of analgesic drugs, sensory loss, etc. The effect of reducing side effects and simple preparation method

Pending Publication Date: 2018-09-14
刘艳霞
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Analgesics act on the peripheral and central nervous systems through various mechanisms, including paracetamol (acetaminophen, also known as acetaminophen); non-steroidal anti-inflammatory drugs (NSAIDs), such as salicylic acid salts; opioids, such as morphine and opium; and drugs for local analgesia / anesthesia, such as lidocaine and benzocaine, which are different from general anesthetics, which Reversibly make the patient unconscious and unaware of the surrounding environment. Local anesthesia leads to loss of sensation, while analgesia reduces pain sensation. There are many types of analgesics on the market today, with different effects. Slow, and the side effects of analgesic drugs are relatively large, which cannot meet the current use requirements

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] The present invention proposes a pharmaceutical composition with analgesic function, comprising the following raw materials in parts by weight: 2 parts of arnica, 2 parts of sodium hyaluronate, 3 parts of hydroxypropyl cellulose, 10 parts of anti-inflammatory 3 parts of Loxamer, 3 parts of Cortex Moutan, 10 parts of Chuanxiong, 11 parts of Aconitum, 7 parts of Sanqi, 3 parts of Smilax, 7 parts of Asarum, 3 parts of Aconite, 3 parts of Radix Paeoniae Rubra;

[0018] Its preparation method comprises the following steps:

[0019] S1: Crush Moutan Cortex, Chuanxiong, Chuanwu, Sanqi, Smilax, Asarum, Aconite, Radix Paeoniae Rubra and Arnica, and grind them into coarse powder;

[0020] S2: Mix Moutan Cortex, Chuanxiong, Aconitum, Panax notoginseng, Smilax tuckahoe with sodium hyaluronate and hydroxypropyl cellulose as described in S1, mix evenly, soak in ethanol for 9-13 hours, and then recover under reduced pressure Ethanol, concentrated to a thick paste with a relative dens...

Embodiment 2

[0023] The present invention proposes a pharmaceutical composition with analgesic function, comprising the following raw materials in parts by weight: 5 parts of arnica, 4 parts of sodium hyaluronate, 5 parts of hydroxypropyl cellulose, 15 parts of anti-inflammatory 5 parts of Loxamer, 4 parts of Cortex Moutan, 12 parts of Chuanxiong, 15 parts of Aconitum, 10 parts of Sanqi, 6 parts of Smilax, 9 parts of Asarum, 6 parts of Aconite, 5 parts of Radix Paeoniae Rubra;

[0024] Its preparation method comprises the following steps:

[0025] S1: Crush Moutan Cortex, Chuanxiong, Chuanwu, Sanqi, Smilax, Asarum, Aconite, Radix Paeoniae Rubra and Arnica, and grind them into coarse powder;

[0026] S2: Mix Cortex Moutan, Rhizoma Chuanxiong, Aconitum Aconitum, Panax notoginseng, Smilax smilax, sodium hyaluronate and hydroxypropyl cellulose as described in S1, mix evenly, soak in ethanol for 11 hours, then recover ethanol under reduced pressure, Concentrate to a thick paste with a relative...

Embodiment 3

[0029] The present invention proposes a pharmaceutical composition with analgesic function, comprising the following raw materials in parts by weight: 10 parts of arnica, 6 parts of sodium hyaluronate, 7 parts of hydroxypropyl cellulose, 20 parts of anti-inflammatory agent, 7 parts of poloxamer, 6 parts of Moutan bark, 15 parts of Chuanxiong, 17 parts of Chuanwu, 15 parts of Sanqi, 8 parts of Smilax, 13 parts of Asarum, 9 parts of aconite, 7 parts of red peony ;

[0030] Its preparation method comprises the following steps:

[0031] S1: Crush Moutan Cortex, Chuanxiong, Chuanwu, Sanqi, Smilax, Asarum, Aconite, Radix Paeoniae Rubra and Arnica, and grind them into coarse powder;

[0032] S2: Mix Moutan Cortex, Chuanxiong, Aconitum, Panax notoginseng, Smilax smilax, sodium hyaluronate and hydroxypropyl cellulose as described in S1, mix evenly, soak in ethanol for 13 hours, then recover ethanol under reduced pressure, Concentrate to a thick paste with a relative density of 1.45; ...

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PUM

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Abstract

The invention discloses a pharmaceutical composition with an analgesic function. The pharmaceutical composition comprises, by weight, 2-10 parts of arnica montana, 2-6 parts of sodium hyaluronate, 3-7parts of hydroxypropyl cellulose, 10-20 parts of anti-inflammatory agent, 3-7 parts of poloxamer, 3-6 parts of cortex moutan, 10-15 parts of rhizoma chuanxiong, 11-17 parts of radix aconiti, 7-15 parts of panax notoginseng, 3-8 parts of rhizoma smilacis glabrae, 7-13 parts of herba asari, 3-9 parts of aconitum carmichaeli and 3-7 parts of radix paeoniae rubra. A preparation method of the composition includes the following steps of S1, crushing and grinding cortex moutan, rhizoma chuanxiong, radix aconit, panax notoginseng, rhizoma smilacis glabrae, herba asari, aconitum carmichaeli, radix paeoniae rubra and arnica montana into coarse powder; S2, uniformly mixing cortex moutan, rhizoma chuanxiong, radix aconit, panax notoginseng and rhizoma smilacis glabrae in S1 with sodium hyaluronate and hydroxypropyl cellulose, placing the mixture above into ethanol for soaking for 9-13 hours, recovering ethanol under reduced pressure and conducting concentration until thick paste with relative density of 1.40-1.45 is obtained. Traditional Chinese medicine is adopted, side effects caused by medicine can be alleviated, analgesia can be effectively achieved, and the preparation method is simple.

Description

technical field [0001] The invention relates to the field of pharmaceutical compositions, in particular to a pharmaceutical composition with analgesic function. Background technique [0002] Pain is defined as an unpleasant sensory and emotional experience. Millions of people suffer from pain ranging from mild headaches to debilitating chronic pain. Acute pain may be associated with a medical procedure or injury. Chronic pain may be associated with conditions such as cancer, HIV or diabetes. Currently available medications for pain management have significant associated adverse effects such as nausea, vomiting, intolerance, constipation, dyspepsia, myocardial infarction, stroke, and chemical dependence, analgesics (also known as pain relievers) Is the generic name of a drug used to reduce pain (achieve analgesia). Analgesics act on the peripheral and central nervous systems through various mechanisms, including paracetamol (acetaminophen, also known as acetaminophen); no...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/896A61K36/90A61K45/06A61P29/00
CPCA61K36/236A61K36/258A61K36/268A61K36/28A61K36/65A61K36/71A61K36/714A61K36/896A61K36/90A61K45/06A61K2236/33A61K2236/331A61K2236/51A61P29/00A61K2300/00
Inventor 刘艳霞
Owner 刘艳霞
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