Macroporous Prussian blue nanoparticles and preparation method thereof

A Prussian blue and nanoparticle technology, which is applied in the field of macroporous Prussian blue nanoparticles and its preparation, can solve the problems of difficult gene protection and mesoporous nanoparticle loading, and achieve low raw material cost, low raw material cost, The effect of broad application prospects

Active Publication Date: 2018-09-18
SHANGHAI SIXTH PEOPLES HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, the size of biomacromolecules (such as siRNA, DNA, etc.) is 5-20nm, and it is difficult for ordinary mesoporous nanoparticles to carry them, so it is difficult to achieve gene protection and gene therapy for tumors
[0004] At present, there are few reports on the synthesis of macroporous Prussian blue nanoparticles

Method used

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  • Macroporous Prussian blue nanoparticles and preparation method thereof
  • Macroporous Prussian blue nanoparticles and preparation method thereof
  • Macroporous Prussian blue nanoparticles and preparation method thereof

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[0033] The invention relates to a preparation method of macroporous Prussian blue nanoparticles. The macroporous Prussian blue nanoparticles have small particle size, adjustable particle size and pore size, high specific surface area and pore volume, and are very beneficial to reactions involving macromolecules, such as petroleum catalytic products. Prussian blue is an antidote approved by the US Food and Drug Administration for clinical use in thallium poisoning. It has great potential application prospects in drug carriers, especially for loading biological macromolecules. The synthesized macroporous Prussian blue nanoparticles have extremely broad application prospects in drug delivery, adsorption, separation, catalysis, batteries, and tumor diagnosis and treatment. The synthesis method of the invention is simple, novel, low in cost and high in efficiency.

[0034] The chemical formula of the prepared Prussian blue nanoparticles is A x Fe y [Fe(CN) 6 ] z (A=Na, K; x: 0...

Embodiment 1

[0046] Embodiment 1 prepares the method for the Prussian blue nano-particle of small particle size super large aperture, comprises the following steps:

[0047] Step A) Add 250-3960 mg of potassium ferrocyanide and 3-35 g of polyvinylpyrrolidone (PVP) into 30-100 mL of 1-2M hydrochloric acid, and magnetically stir until a clear mixed solution is obtained;

[0048] Step B) Transfer the mixed solution to an oven at 80°C, age for 12-20 hours, take it out, cool to room temperature, centrifuge, wash with deionized water several times, dissolve in 20-50mL of hydrochloric acid with a concentration of 1-2M and set aside;

[0049] Step C) Transfer 20mL of the above solution to a hydrothermal kettle, place in an electric furnace, age at 120-140°C for 2-4h, take it out and cool to room temperature, centrifuge, wash with deionized water several times, and freeze-dry to obtain a pore size of 30-200nm mesoporous Prussian blue nanoparticles in the 3-20nm range.

Embodiment 2

[0050] Embodiment 2 prepares the method for the Prussian blue nano-particle with small particle diameter and super large aperture, comprises the following steps:

[0051] Step A) Add 250-3960 mg of potassium ferrocyanide and 3-35 g of polyvinylpyrrolidone (PVP) into 30-100 mL of 1-2M hydrochloric acid, and magnetically stir until a clear mixed solution is obtained;

[0052] Step B) Transfer the mixed solution to an oven at 80°C, age for 12-20 hours, take it out, cool to room temperature, centrifuge, wash with deionized water several times, dissolve in 20-50mL of hydrochloric acid with a concentration of 6-10M and set aside;

[0053] Step C) Transfer 20mL of the above solution to a hydrothermal kettle, place in an electric furnace, age at 25-60°C for 6-10h, take it out and cool to room temperature, centrifuge, wash with deionized water several times, and freeze-dry to obtain a pore size of 30-200nm mesoporous Prussian blue nanoparticles in the 3-5nm range.

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Abstract

The invention discloses macroporous Prussian blue nanoparticles and a preparation method thereof. The preparation method comprises the following steps of: (1) adding an iron source and an organic substance with effects of reduction and stabilization into an acidic solution S1, and performing magnetic stirring until a clear mixed solution is obtained; (2) transferring the mixed solution to an ovenof a temperature of T1 DEG C, performing aging for H1 hours, cooling to room temperature, performing centrifugal separation, performing washing with deionized water multiple times, and performing dissolution in an acidic solution S2 for later use; and (3) transferring the solution to a hydrothermal kettle, placing the hydrothermal kettle in an electric furnace at a temperature of T2 DEG C, performing aging, cooling to room temperature, performing centrifugal separation, conducting water washing, and carrying out drying to obtain the macroporous Prussian blue nanoparticles with a pore size of 3-20 nm and a size of 20-200 nm. The prepared macroporous Prussian blue nanoparticles have the characteristics of high dispersion and uniform size, and have a simple preparation process, low raw material cost, easy regulation, a novel method and an extremely wide application prospect.

Description

technical field [0001] The invention belongs to the technical field of nanometer materials, and relates to a macroporous Prussian blue nanoparticle and a preparation method thereof. Background technique [0002] Prussian blue (Prussian blue, PB), as a dye with a long history, has attracted great attention in the past 300 years since its accidental discovery by Berlin chemist Diesbach (Diesbach) in 1704. PB has nanoparticles with tunable size, morphology, and surface, and can control the assembly of nanoparticles and adjust their physical and chemical properties. Owing to their electrochemical, photoelectrochemical, magnetic, and optical properties, PB nanostructures have attracted great interest in applications including batteries, electrochromic displays, fuel cells, gas storage, sensors, and signal-enhancing nanodevices. [0003] Mesoporous materials have received great attention due to their high specific surface area, large pore volume, tunable mesostructure and pore si...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01C3/12A61K41/00A61K47/69A61K49/22B82Y30/00B82Y40/00
CPCA61K41/0052A61K49/22A61K47/6949B82Y30/00B82Y40/00C01C3/12C01P2004/62C01P2004/64C01P2006/12C01P2006/14C01P2006/17
Inventor 蔡晓军高维郑元义胡兵陈捷陈磊姜立新
Owner SHANGHAI SIXTH PEOPLES HOSPITAL
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