Novel nanometer drug and preparation method thereof

A nano-drug and nano-particle technology, used in drug combinations, pharmaceutical formulations, anti-tumor drugs, etc., can solve the problems of low drug-carrying capacity and drug-carrying efficiency of carriers, affecting biological functions, and difficult to accurately control, and achieve a therapeutic approach. Synergy, guaranteed safety and low cost

Inactive Publication Date: 2018-09-21
SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] However, the preparation of various drug delivery carriers usually requires complex synthetic schemes, including supramolecular self-assembly and chemical modification. These processes are always difficult to precisely control and have poor reproducibility, resulting in extremely low drug-loading capacity and drug-loading efficiency. , limiting its effectiveness in in vitro and in vivo experiments
At the same time, one or more inorganic materials, metal materials, and polymer materials are used in the pr

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  • Novel nanometer drug and preparation method thereof
  • Novel nanometer drug and preparation method thereof
  • Novel nanometer drug and preparation method thereof

Examples

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Example Embodiment

[0053] figure 1 A flow chart showing a processing method for preparing a self-assembled nanomedicine according to an embodiment of the present invention. like figure 1 As shown, first, a drug solution is prepared. Specifically, the hydrophobic drug was dissolved in dimethyl sulfoxide to obtain a first solution. Dissolve indocyanine green in water or NaHCO 3 In an aqueous solution, a second solution is obtained.

[0054] In the first solution, the concentration of the hydrophobic drug may be 0.5-2 g / L.

[0055] In the second solution, the concentration of indocyanine green may be 0.2˜1 g / L. In the second solution, if NaHCO is selected 3 Aqueous solution as solvent, then NaHCO 3 In aqueous solution, NaHCO 3 The concentration can be 0.02 ~ 5mM.

[0056] Then, the drugs are uniformly mixed and self-assembled to form nanodrugs. Specifically, the first solution and the second solution are mixed. The mixing process of the two is the process of self-assembly to form nano-dr...

Example Embodiment

[0066] Example 1

[0067] Dissolve 1 mg of paclitaxel in 0.1 mL of DMSO to prepare a 10 mg / mL organic solution; prepare 1 mg / mL of ICG in NaHCO 3 (0.05mM) aqueous solution; under ultrasonic vibration, 0.1 mL of paclitaxel in DMSO was added dropwise to 0.6 mL of ICG solution at a rate of 20 μL every 15 s, so that the solution was evenly mixed and self-assembled rapidly to form nano-drugs; centrifuged to collect (17000 rpm, 30 min) to obtain the precipitation of drug nanoparticles; washed with PBS, and finally uniformly dispersed in 1 mL of PBS.

[0068] figure 2 This is the TEM image of the paclitaxel-ICG self-assembled nanomedicine synthesized in Example 1, which intuitively shows a regular spherical shape, a uniform particle size and a high degree of dispersion.

[0069] Figure 10 The particle size distribution diagram of the paclitaxel-ICG self-assembled drug synthesized in Example 1 is shown. It can be seen that the hydrodynamic diameter of the paclitaxel-ICG self-asse...

Example Embodiment

[0071] Example 2

[0072] Dissolve 1 mg of camptothecin in 0.1 mL of DMSO to prepare a 10 mg / mL organic solution; prepare 1 mg / mL of ICG in NaHCO 3 (0.05mM) aqueous solution; under ultrasonic vibration, 0.1 mL of camptothecin in DMSO was added dropwise to 0.6 mL of ICG solution at a rate of 20 μL every 15 s, so that the solution was mixed uniformly and self-assembled rapidly to form nano-drugs; Collected by centrifugation (17000rpm, 30min) to obtain the precipitation of drug nanoparticles; washed with PBS, and finally uniformly dispersed in 1 mL of PBS.

[0073] image 3 This is the TEM image of the camptothecin-ICG self-assembled nanomedicine synthesized in Example 2, which intuitively shows regular spherical morphology, uniform particle size and high dispersibility.

[0074] Figure 11 The particle size distribution diagram of the camptothecin-ICG self-assembled drug synthesized in Example 2 is shown. It can be seen that the hydration kinetic diameter of the camptothecin-...

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Abstract

The invention discloses a novel nanometer drug and a preparation method thereof. The nanometer drug belongs to nanometer particles formed by self-assembling hydrophobic drug and indocyanine green.

Description

technical field [0001] The invention belongs to the technical field of drug nanotechnology, and relates to a novel nano drug with high dispersibility, stability, controllable particle size, no additional carrier, and each component is a drug approved by the U.S. Food and Drug Administration (FDA). its preparation method. Background technique [0002] In order to solve the defects of small-molecule tumor therapeutic drugs, especially hydrophobic drugs, with short circulation period in vivo, low tumor targeting, and easy damage to normal cells, researchers have designed a variety of drug delivery systems to encapsulate small-molecule therapeutic drugs Into the interior of biocompatible nanocarrier particles to achieve long cycle, active or passive targeted and controlled drug release. For example, in 2001, researchers discovered that MCM-41 mesoporous SiO 2 It has efficient drug storage and sustained release properties (Chem. Mat. 2001, 13, (2), 308-311) and good biocompatib...

Claims

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Application Information

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IPC IPC(8): A61K9/14A61K47/22A61K31/337A61K31/4745A61K31/44A61P35/00
CPCA61K9/145A61K31/337A61K31/44A61K31/4745A61P35/00
Inventor 蒋渠子于罗丹陈雨
Owner SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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