Electrochemical sensor based on chiral covalent organic framework compound

A covalent organic framework and sensor technology, applied in the field of electrochemical detection, can solve problems such as design, synthesis, functionalization difficulties, and limited analysis and application, and achieve the effects of excellent capacitance performance, obvious enrichment effect, and good conductivity

Active Publication Date: 2018-09-21
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Due to many difficulties in design, synthesis and functionalization, its analytical application is limited
At present, no COFs electrochemical sensor with this performance has been constructed, so the present invention creatively designs this electrochemical sensor based on chiral covalent organic framework materials, and applies it to chiral compounds and compounds with π-conjugated structures. Sensing of Small Molecule Electroactive Substances

Method used

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  • Electrochemical sensor based on chiral covalent organic framework compound
  • Electrochemical sensor based on chiral covalent organic framework compound
  • Electrochemical sensor based on chiral covalent organic framework compound

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Weigh 2.5 mg of the four materials of COF-CTpPa-2, COF-TpPa-1, COF-TpPa-2 and COF-TpBD respectively, dissolve them in 5.0 mL of ethanol-Nafion solution, and continue ultrasonication for 3 hours until the materials are evenly distributed in, And refrigerated storage at 4 °C; use 3 μm and 0.05 μm alumina powder to grind and polish the electrode, and then in turn, the electrode is ultrasonicated in nitric acid (concentrated nitric acid:water, 1:3, V:V) for 30 s, and in ethanol for 1 min. Sonicate in water for 1 min, blow dry with nitrogen; drop 5 μL of the four material solutions on the electrodes, and then dry them at room temperature, and the electrochemical sensors of the four materials are prepared.

[0037] Such as figure 1 Shown are the effects of electrochemical sensors modified by four different COF materials: COF-CTpPa-2, COF-TpPa-1, COF-TpPa-2 and COF-TpBD.

[0038] The prepared electrical sensor was placed in 1 mM potassium ferricyanide solution, the scanning r...

Embodiment 2

[0040] Such as figure 2 Shown, is the principle verification of the present invention.

[0041] The COF-CTpPa-2 electrochemical sensor prepared in Example 1 was characterized by SEM and XRD diffraction, figure 2 A and figure 2 B are the SEM images of the COF-CTpPa-2 modified electrode and the electrode, respectively. It can be seen from the figure that the surface of the glassy carbon electrode modified by COF-CTpPa-2 is wrinkled and distributed with small holes of uniform pore size. Wrinkles and small holes increase the effective area of ​​the electrode surface, which is beneficial to the further enrichment of the analyte. figure 2 C is the XRD diffraction pattern of COF-CTpPa-2. It can be seen from the figure that COF-CTpPa-2 has diffraction peaks at 4.7°, 8.1° and 25.2°, which is consistent with the literature reports, indicating that the synthesized is COF - CTpPa-2 compound.

[0042] The prepared electric sensor was placed in 1mM potassium ferricyanide solution, t...

Embodiment 3

[0044] Such as image 3 Shown is the application of COF-CTpPa-2 electrochemical sensor to electroactive substances with π-conjugated structure and different molecular diameters.

[0045] Depend on image 3 A It is known that the pore size of COF-CTpPa-2 is about Draw phenol and tetracycline through online painting software, and get the molecular diameters of phenol and tetracycline through testing tools as with

[0046] The prepared COF-CTpPa-2 electrochemical sensor was placed in an electrolyte solution containing 50 μM phenol and tetracycline respectively, connected to a power supply, and scanned by differential pulse voltammetry with a scanning potential of -0.5V to 1.2V.

[0047] image 3 A is the pore diameter of COF-CTpPa-2, image 3 B is the molecular diameter of phenol and tetracycline, it can be seen that the pore diameter of CTpPa-2 is about The molecular diameters of phenol and tetracycline are with image 3 C is the electrochemical response diagram ...

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Abstract

The invention discloses an electrochemical sensor based on a chiral covalent organic framework compound and belongs to the technical field of electrochemical detection. The electrochemical sensor disclosed by the invention is obtained by modifying the covalent organic framework compound COF-CTpPa-2 on a matrix electrode, and can be used for enriching and separating a small molecular electric active substance with a pi conjugated structure; when the molecular diameter of a substance is less than the pore diameter of the COF-CTpPa-2, the enrichment effect of the sensor on the substance is more obvious when the quantity of benzene rings of the substance is more; meanwhile, the electrochemical sensor also can be used for distinguishing and identifying the chiral compound.

Description

technical field [0001] The invention relates to an electrochemical sensor based on a chiral covalent organic framework compound, belonging to the technical field of electrochemical detection. Background technique [0002] In 1975, there was a breakthrough in traditional electrochemistry, which was limited to the study of bare electrodes or electrolyte interfaces, and created the field of artificially controlling the electrode surface structure. By molecular tailoring of the electrode surface, the electrode is functionalized as envisioned. Based on this, modified electrodes have been developed, and it seems that it is still one of the very active research fields in electrochemistry. There is no doubt that the selection of modified materials is a key part of the research process of modified electrodes. Excellent modified materials can modify the electrode surface through physical and chemical methods, change the electrode interface area, and thus increase the active area of ​...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/30
CPCG01N27/30
Inventor 庞月红王黎沈晓芳钱海龙严秀平
Owner JIANGNAN UNIV
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