Biodegradable high-strength polyether ester type polyurethane urea foam and preparation method thereof

A technology of polyurethane urea and polyether ester is applied in the field of preparation of fully synthetic biodegradable hemostatic foam, which can solve the problems of difficult adjustment of the ratio of soft and hard segments, difficult control of the content of hydrophilic segments, unsatisfactory hemostatic effect, and the like. The effect of compression hemostasis, excellent water absorption and good biocompatibility

Active Publication Date: 2018-09-28
济南羽时信息科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it does not contain urea group, its strength is low, and its hemostatic effect is not ideal for trauma with large bleeding
[0009] The emergence and development of biodegradable absorbent swelling hemostatic materials have increased the comfort of patients undergoing ear and nose cavity surgery, but there are problems such as long response

Method used

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  • Biodegradable high-strength polyether ester type polyurethane urea foam and preparation method thereof
  • Biodegradable high-strength polyether ester type polyurethane urea foam and preparation method thereof
  • Biodegradable high-strength polyether ester type polyurethane urea foam and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0063] Preparation of diisocyanate chain extender containing ureido structure:

[0064] Preparation of LBL: Under dry nitrogen protection and mechanical stirring, add 1,4-butanediamine dropwise to L-lysine diisocyanate (-NCO:-NH 2 =8:1, molar ratio), after reacting at room temperature for 2h, add four times the volume of n-hexane to the reaction product, after stirring evenly, obtain a white solid by suction filtration, wash with n-hexane repeatedly until the filtrate IR detects that there is no -NCO absorption Peak (2270cm -1 ), vacuum-dried to constant weight to obtain white powder LBL.

[0065] Preparation of LHL: Add 1,6-hexanediamine dropwise to L-lysine diisocyanate (-NCO:-NH 2 =10:1, molar ratio), after reacting at room temperature for 2h, add four times the volume of n-hexane to the reaction product, after stirring evenly, obtain a white solid by suction filtration, wash with n-hexane repeatedly until the filtrate IR detects that there is no -NCO absorption Peak (22...

Embodiment 2

[0067] Take 10.0g (7.7mmol) PPDO-PEG-PPDO (M n =1300, the PEG content is 19.23wt%) was added to N,N-dimethylformamide (DMF) to dissolve (0.5g / mL), the reaction system was cooled to 85°C, and the DMF solution of LBL (8.0mmol) was added dropwise ( 1.0g / mL), after the dropwise addition, keep the temperature and continue to react for 4h, lower to room temperature, then add DMF to make a solution with a concentration of about 10g / 100mL, 7 times the volume of glacial ether settles, and the obtained solid is vacuum-dried at 35°C to obtain polyether Ester polyurethane urea;

[0068] The polyurethane urea was dissolved in dioxane at concentrations of 4.5g / 100mL, 5.0g / 100mL, and 5.5g / 100mL, pre-frozen at -15.5°C for 4 hours, and then vacuum-frozen at -50°C to obtain a foam. Denote as samples I-a, I-b, and I-c, respectively.

Embodiment 3

[0070] Take 8.0g (4.4mmol) PPDO-PEG-PPDO (M n =1800, the PEG content is 11.11wt%) was added to N,N-dimethylformamide (DMF) to dissolve (0.5g / mL), the reaction system was cooled to 80°C, and the DMF solution of LHL (4.6mmol) was added dropwise ( 1.0g / mL), after the dropwise addition, keep the temperature and continue to react for 5h, lower to room temperature, then add DMF to make a solution with a concentration of about 9g / 100mL, 8 times the volume of glacial ether settles, and the obtained solid is vacuum-dried at 35°C to obtain polyether Ester polyurethane urea;

[0071] The polyurethane urea was dissolved in dioxane at a concentration of 5.0 g / 100 mL, and freeze-dried to obtain a foam. Denoted as sample II.

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Abstract

The invention relates to the technical field of biodegradable materials, specifically to a preparation method for a fully-synthetic biodegradable high-strength hemostatic foam applicable to hemostasisof cavities like ears and noses of human or animals. The biodegradable high-strength polyether ester type polyurethane urea foam is prepared from a polyether ester type polyurethane urea material through freeze-molding, wherein the polyether ester type polyurethane urea is prepared through chain extension of dihydroxy-terminal triblock prepolymer by using diisocyanate with a urea structure as a chain extender; the polyurethane urea material has a number average molecular weight of 1.1 x 105 to 1.8 x 105 and a dispersion coefficient of 1.18 to 1.51; and the diisocyanate chain extender containing the urea structure is selected from the group consisting of L-lysine diisocyanate-1,4-butadiamine-L-lysine diisocyanate and L-lysine diisocyanate-1,6-hexane diamine-L-lysine diisocyanate.

Description

technical field [0001] The invention relates to the technical field of biodegradable materials, in particular to a preparation method of a fully synthetic biodegradable hemostatic foam suitable for hemostasis in ears, noses or other cavities of humans or animals. Background technique [0002] Ear and nose surgery is a common surgical operation. Due to the small scope of ear and nose surgery, the local blood vessels are abundant, easy to bleed, and the location is deep, so it cannot be sutured to stop bleeding after surgery, and it must rely on packing to stop bleeding. The purpose of packing is to reduce the pain of patients as much as possible while ensuring hemostasis and anti-adhesion. Therefore, the selection of postoperative packing materials has long been the focus of attention. [0003] In the case of surgical hemostasis in cavities such as ears and nose, traditional non-biodegradable packing materials are usually removed within 24-48 hours or even longer postoperativ...

Claims

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Application Information

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IPC IPC(8): C07C273/18C07C275/16A61L24/00A61L24/04C08G18/10C08G18/78C08G101/00
CPCA61L24/0005A61L24/001A61L24/0015A61L24/0036A61L24/0042A61L24/046A61L2300/30A61L2300/402A61L2300/404A61L2300/41A61L2300/412C07C273/1827C08G18/10C08G2101/00C08G18/7825C08L75/04C07C275/16
Inventor 侯昭升时玉祥
Owner 济南羽时信息科技有限公司
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