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Method for detecting content of quercetin in traditional Chinese medicine composition for treating colitis

A detection method and technology for quercetin, applied in the field of medicine, can solve the problems of inability to effectively guarantee product quality, inability to guarantee the efficacy of drugs, and no preparations, etc.

Inactive Publication Date: 2018-10-02
INNER MONGOLIA TIANQI HAN&MONGOLIA PHARMA CO +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The above-mentioned traditional Chinese medicine composition for treating colitis has no preparation quality standard detection method in the prior art, which cannot effectively guarantee product quality in production and use, and thus the curative effect of the medicine cannot be guaranteed

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] prescription:

[0042]Calcite 156.74g, Daqing Salt 31.35g, Celery Leaf Clematis 313.48g, Zhaoshanbai 313.48g, Nutmeg 7.84g, Coriander Seed 7.84g, Dried Ginger 7.84g, Piper longum 7.84g, Ophiopogon japonicus 7.84g, Gu Yue 7.84g, Dikuku 7.84g, Bai Nao Sand 7.84g, Zi Nao Sand 7.84g, Tu Mu Xiang 7.84g, Fire Nitrate 15.67g

[0043] Preparation Process:

[0044] The above fifteen flavors, calcite, Daqing salt, Bai Nao sand, Zi Nao sand, fire salt were separately crushed into very fine powder; Fine powder: mix nutmeg and other twelve flavors with calcite, clematis celery leaf, and Zhaoshanbai powder, sieve, and mix well. Add about 10% microcrystalline cellulose, mix well, add 1% hypromellose solution, mix well, make pills, dry, and obtain.

[0045] Quercetin content detection method:

[0046] Chromatographic conditions and system suitability test: Octadecylsilane bonded silica gel is used as filler, methanol-2% phosphoric acid aqueous solution (52:48) is used as mobile pha...

Embodiment 2

[0052] prescription:

[0053] Calcite 156.74g, Daqing Salt 31.35g, Celery Leaf Clematis 313.48g, Zhaoshanbai 313.48g, Nutmeg 7.84g, Coriander Seed 7.84g, Dried Ginger 7.84g, Piper longum 7.84g, Ophiopogon japonicus 7.84g, Gu Yue 7.84g, Dikuku 7.84g, Bai Nao Sand 7.84g, Zi Nao Sand 7.84g, Tu Mu Xiang 7.84g, Fire Nitrate 15.67g

[0054] Preparation Process:

[0055] The above fifteen flavors, calcite, Daqing salt, Bai Nao sand, Zi Nao sand, fire salt were separately crushed into very fine powder; Fine powder: mix nutmeg and other twelve flavors with calcite, clematis celery leaf, and Zhaoshanbai powder, sieve, and mix well. Add about 10% microcrystalline cellulose, mix well, add 2% hypromellose solution, mix well, add 0.5% magnesium stearate, mix well, compress into tablets, and make tablets.

[0056] Quercetin content detection method:

[0057] Chromatographic conditions and system suitability test: Octadecylsilane bonded silica gel is used as filler, methanol-2% phosphoric...

Embodiment 3

[0063] prescription:

[0064] Calcite 156.74g, Daqing Salt 31.35g, Celery Leaf Clematis 313.48g, Zhaoshanbai 313.48g, Nutmeg 7.84g, Coriander Seed 7.84g, Dried Ginger 7.84g, Piper longum 7.84g, Ophiopogon japonicus 7.84g, Gu Yue 7.84g, Dikuku 7.84g, Bai Nao Sand 7.84g, Zi Nao Sand 7.84g, Tu Mu Xiang 7.84g, Fire Nitrate 15.67g

[0065] Preparation Process:

[0066] The above fifteen flavors, calcite, Daqing salt, Bai Nao sand, Zi Nao sand, fire salt were separately crushed into very fine powder; Fine powder: mix nutmeg and other twelve flavors with calcite, clematis celery leaf, and Zhaoshanbai powder, sieve, and mix well. Add about 10% microcrystalline cellulose and 0.5% magnesium stearate, mix well, pack into capsules, and make capsules.

[0067] Quercetin content detection method:

[0068] Chromatographic conditions and system suitability test: Octadecylsilane bonded silica gel is used as filler, methanol-2% phosphoric acid aqueous solution (52:48) is used as mobile phas...

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PUM

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Abstract

The invention relates to a method for detecting the content of quecetin in a traditional Chinese medicine composition for treating colitis. The traditional Chinese medicine composition is prepared from fifteen Mongolia medicines: calcite, halite, herba clematis aethusifoliae, folium rhododendron micranthi, semen myristicae, fructus coriandri, rhizoma zingiberis, fructus piperis longi, radix ophiopogonis, fructus piperis, radix raphani sativi, white sal ammoniac, purple sal ammoniac, radix inulae and potassium nitrate according to certain weight proportions, and is mainly and clinically used for treating chronic diarrhea; the quercetin is a common component of the herba clematis aethusifoliae and the folium rhododendron micranthi and has relative high content in the herba clematis aethusifoliae and the folium rhododendron micranthi, so that content determination of the quercetin is planned to be selected as a method for controlling medicine quality. Under a selected LC (Liquid Chromatogram) condition, the quercetin in a test solution is in good separation with adjacent components, and no interference of a negative solution exists; methodological investigation shows that tests aboutthe repeatability, the stability, the precision degree and the recovery rate of the method all accord with relevant regulations.

Description

technical field [0001] The invention relates to a drug detection method, in particular to a method for detecting quercetin content in a traditional Chinese medicine composition for treating colitis, and belongs to the technical field of medicine. Background technique [0002] At present, colitis is a disease that mainly invades the rectal and colon mucosa, often forms erosions and ulcers, with diarrhea, abdominal pain, pus and blood in the stool as the main symptoms, and diffuse non-specific inflammation of the large intestine. The disease mostly involves the rectum and distal colon, and then develops to the proximal end, and even affects the entire colon. For the treatment of colitis at home and abroad, western medicine mostly adopts parenteral nutrition, antibiotics, hormones, immunosuppression and surgical treatment. Currently developed new oral or enema 5-aminosalicylic acid preparations can achieve therapeutic effects, but the cost is high and expensive. Therefore, it...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02G01N30/06
CPCG01N30/02G01N30/06
Inventor 齐平于秀玲佘宜寰孔新颖韩风雨
Owner INNER MONGOLIA TIANQI HAN&MONGOLIA PHARMA CO