X-ray imageable drug-loaded microspheres for intravascular embolism and preparation method thereof

A technology of drug-loaded microspheres and microspheres, applied in the medical field, can solve the problems of tracking the degree and scope of unfavorable embolism, and achieve the effect of facilitating quantitative production

Active Publication Date: 2020-11-24
GENERAL HOSPITAL OF PLA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

None of them can be developed under X-ray, and can only be judged indirectly by bolus injection of contrast agent, which is not conducive to tracking the degree and scope of embolism after embolization

Method used

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  • X-ray imageable drug-loaded microspheres for intravascular embolism and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Microsphere preparation

[0023] In this example, an X-ray-developable, non-degradable, and drug-loaded intravascular embolization microsphere was prepared, and its preparation method included the following steps:

[0024] Get the 10% w / v polyvinyl alcohol solution of 15 weight parts, 4 weight parts acrylic acid, 1.6 weight parts ammonium persulfate (used as initiator), 0.4 weight parts N, N-methylenebisacrylamide (used as Cross-linking agent), mixed evenly, and fully impacted to obtain a mixed solution.

[0025] Add 80 parts by weight of liquid paraffin and 0.4 parts by weight of SPAN-80 into a three-necked flask container, set it to 300-600 rpm, and the temperature is 55-60 ° C. After 10 minutes, under the protection of nitrogen, the mixed solution obtained above Add it dropwise into the reaction vessel, after 10 minutes, add 0.4 parts by weight of TEMED (used as a catalyst), maintain 300-600 rpm, temperature 55-60°C, react for 2-6 hours, use Tween-80 Wash off the l...

Embodiment 2

[0041] Microsphere preparation

[0042] In this example, an X-ray-developable, non-degradable, and drug-loaded intravascular embolization microsphere was prepared, and its preparation method included the following steps:

[0043] Get 15 parts by weight of 20% w / v polyvinyl alcohol solution, 4 parts by weight of acrylic acid, 0.8 parts by weight of ammonium persulfate (used as initiator), 0.1 parts by weight of N, N-methylenebisacrylamide (used as Cross-linking agent), mixed evenly, and fully impacted to obtain a mixed solution.

[0044] Add 80 parts by weight of liquid paraffin and 0.8 parts by weight of SPAN-80 into a three-necked flask container, set it to 300-600 rpm, and the temperature is 55-60 ° C. After 10 minutes, under the protection of nitrogen, the mixed solution obtained above Add it dropwise into the reaction vessel, after 10 minutes, add 0.4 parts by weight of TEMED (used as a catalyst), maintain 300-600 rpm, the temperature is 55-60 ° C, react for 2-6 hours, us...

Embodiment 3

[0054] Microsphere preparation

[0055] In this example, an X-ray-developable, non-degradable, and drug-loaded intravascular embolization microsphere was prepared, and its preparation method included the following steps:

[0056] Get 20 parts by weight of polyvinyl alcohol solution of 5% w / v, 6 parts by weight of acrylic acid, 0.6 parts by weight of ammonium persulfate (used as initiator), 0.2 parts by weight of N, N-methylenebisacrylamide (used as Cross-linking agent), mixed evenly, and fully impacted to obtain a mixed solution.

[0057] Add 90 parts by weight of liquid paraffin and 0.6 parts by weight of SPAN-80 into a three-necked flask container, set it to 300-600 rpm, and the temperature is 55-60 ° C. After 10 minutes, under the protection of nitrogen, the mixed solution obtained above Add it dropwise into the reaction vessel, after 10 minutes, add 0.4 parts by weight of TEMED (used as a catalyst), maintain 300-600 rpm, the temperature is 55-60 ° C, react for 2-6 hours, ...

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Abstract

The invention discloses a drug-loading microsphere capable of developing under X-ray for intravascular embolization. The drug-loading microsphere is characterized by being prepared from the followingraw materials in parts by weight: 3 to 35 parts of 5-25%w / v polyvinyl alcohol solution, and 1 to 10 parts of acrylic acid; the drug-loading microsphere is a microsphere obtained after barium precipitation. The drug-loading microsphere has the advantages that a simple, economic and batch-production type manufacturing technology of the nondegradable drug-loading microsphere capable of developing under the X-ray is provided; the prepared microsphere can be developed under the X-ray, cannot be degraded, and can carry drug for the intravascular embolization.

Description

technical field [0001] The invention relates to the field of medical technology, in particular to X-ray-developable drug-loaded microspheres for intravascular embolism and a preparation method thereof. Background technique [0002] At present, endovascular embolization is an important treatment for benign and malignant tumors. Currently, the clinically used embolic materials include non-drug-loadable embolic materials (gelatin sponge particles, polyvinyl alcohol [PVA], Embosphere, etc.), drug-loadable embolic materials, etc. Microspheres (DC-Bead, Galisheng microspheres, Hepasphere microspheres, etc.). None of them can be developed under X-ray, and can only be judged indirectly by bolus injection of contrast agent, which is not conducive to tracking the degree and scope of embolism after embolization. Contents of the invention [0003] The object of the present invention is to provide an X-ray imageable drug-loaded microsphere for intravascular embolism and a preparation ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K49/04A61L24/06A61L24/00
CPCA61L24/001A61L24/0015A61L24/06A61L2300/416C08L29/04
Inventor 张金龙王涛王茂强申辽付金鑫袁凯
Owner GENERAL HOSPITAL OF PLA
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