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Ozone active oil soft capsule and preparation method and application thereof

A technology of tri-oxygen active oil and soft capsule, applied in the field of medicine, can solve the problems of destruction of normal intestinal flora, damage of alveolar epithelial cells, influence of defecation reflex, etc. The effect of easy storage and transport

Inactive Publication Date: 2018-11-16
广东祈福医院有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, frequent enemas will affect the normal defecation reflex and damage the already fragile normal flora of the intestinal tract, and irregular enemas may also cause mechanical damage to the intestinal tract; especially the elderly, children and people with weak constitutions , regular enema will stimulate the stomach, but it will make the intestinal flora imbalance
At the same time, the operation of enema requires high technical requirements, and it must be operated with regular equipment and professional medical personnel.
[0004] Ozone is non-toxic but has a strong irritation to the respiratory tract, because ozone can damage the alveolar epithelial cells, and it is strictly forbidden to inhale ozone directly into the lungs
[0005] Therefore, how to solve the inconvenient administration of ozone and improve the drug compliance of patients, and solve the irritation of the respiratory tract and drug effectiveness of oral administration of ozone, etc., urgently need to be studied and solved.

Method used

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  • Ozone active oil soft capsule and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1 3

[0042] The preparation method of embodiment 1 three oxygen oil soft capsules

[0043] 1. Preparation of Trioxygen Oil

[0044] Olive oil 4000mL (density 0.91g / cm 3 ) in a glass container; there are two screw caps on it, one for the inlet of ozone and the other for the outlet of residual ozone, connected to an ozone detector (IDEAL-2000), and using high oxygen liquid The preparation instrument (model ZAMT-Y01) was continuously produced for 9 days, 9 hours a day, that is, a total of 81 hours, the inlet ozone concentration was 100 μg / mL, and the speed was 1 L / min; the outlet ozone concentration was 14.5 μg / mL, and the speed was 1L / min; detect and control the effective conversion rate of ozone by an ozone detector to be 85.5%, and produce ozone oil containing 12% mass percent ozone.

[0045] 2. mix

[0046] Get 60.05% of the trioxygen oil prepared in step 1 by mass percentage and put it into the batching tank, stir while adding, after stirring evenly, filter through 200 mesh, a...

Embodiment 2 3

[0057] The preparation of embodiment 2 three oxygen oil soft capsules

[0058] In an environment of 16°C, use a hyperoxic liquid preparation instrument (model ZAMT-Y01) to continuously produce for 10 days, 11.2 hours a day, that is, a total of 112 hours, the inlet ozone concentration is 100 μg / mL, and the speed is 1L / min; The ozone concentration was 14.5 μg / mL, and the speed was 1 L / min; other operations were the same as in Example 1, and the ozone oil containing 16% by mass of ozone was prepared, and the effective conversion rate of ozone was 85.5%.

[0059] Take 8.37% of glycerin, 20.92% of gelatin, 20.91% of purified water, and 49.80% of trioxygen oil according to the mass percentage, and obtain the trioxygen oil soft capsule through the preparation method of Example 1.

Embodiment 3 3

[0060] The preparation of embodiment 3 three oxygen oil soft capsules

[0061] In an environment of 16°C, use a hyperoxic liquid preparation instrument (model ZAMT-Y01) to continuously produce for 15 days, 9.8 hours a day, that is, a total of 147 hours, with an inlet ozone concentration of 100 μg / mL and a speed of 1 L / min; The ozone concentration was 14.5 μg / mL, and the speed was 1 L / min; other operations were the same as in Example 1, and the ozone oil containing 20% ​​by mass of ozone was obtained, and the effective conversion rate of ozone was 85.5%.

[0062] Get 20.90% glycerin, 27.50% gelatin, 10.65% purified water, and 40.95% trioxygen oil by mass percentage, and other operations are the same as in Example 1 to obtain trioxygen oil soft capsules.

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Abstract

The invention provides an ozone active oil soft capsule and a preparation method and application thereof. The content of the ozone active oil soft capsule is 40% to 61% by mass of ozone oil. The softcapsule can realize the oral administration of ozone, greatly alleviates the suffering of patients with alteration of intestinal flora, avoids the irritating effect of oral ozone on respiratory tracts, can be used for regulating the gastrointestinal flora, promoting digestion, relaxing bowels, has auxiliary protective functions for gastric mucosal damage, gum swelling, oral ulcers, skin inflammation, and the like, and is exact in curative effect. The invention also provides the preparation method of the ozone active oil soft capsule, the preparation method is simple and easy in production process, can be applied to industrial production, can stably and stably produce qualified products, and has broad application prospects.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a three-oxygen active oil soft capsule and its preparation method and application. Background technique [0002] The chemical formula for ozone is O 3 , has a pungent smell, also known as ozone. Ozone is a natural oxidant. High-purity O3 has the effect of killing various bacteria, viruses, fungi, etc., and has the characteristics of "green" sterilization. At present in Europe, ozone is mainly used in the treatment of lumbar disc herniation and bone and joint diseases, the treatment of trauma and refractory ulcers (such as diabetic foot), the adjuvant treatment of cancer, anti-free radical anti-aging, stroke and viral hepatitis, etc. The treatment of diseases, its clinical efficacy has been fully affirmed. [0003] Irritable bowel syndrome is one of the diseases with the highest incidence in gastroenterology. Studies have pointed out that there is a relationship between irri...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K33/00A61K35/741A61K35/742A61P1/10A61P1/02A61P17/04A61P37/08A61P17/06A61P1/14A61P1/04A61P31/04
CPCA61K9/0014A61K9/0056A61K9/4858A61K33/00A61K35/741A61K35/742A61P1/02A61P1/04A61P1/10A61P1/14A61P17/04A61P17/06A61P31/04A61P37/08A61K2300/00
Inventor 彭磷基
Owner 广东祈福医院有限公司
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