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Preparation method of GdF3:Yb<3+>,Er<3+> upconversion fluorescent nanorods

A fluorescent nanometer and solution preparation technology, applied in chemical instruments and methods, luminescent materials, etc., can solve problems such as affecting the rate of cell phagocytosis, and achieve the effects of uniform particle size, short process flow, and simple operation.

Inactive Publication Date: 2018-11-16
TIANJIN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0009] Fourth, the shape of the particle and the local shape of the binding site can affect its rate of engulfment by cells

Method used

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  • Preparation method of GdF3:Yb&lt;3+&gt;,Er&lt;3+&gt; upconversion fluorescent nanorods
  • Preparation method of GdF3:Yb&lt;3+&gt;,Er&lt;3+&gt; upconversion fluorescent nanorods
  • Preparation method of GdF3:Yb&lt;3+&gt;,Er&lt;3+&gt; upconversion fluorescent nanorods

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Experimental program
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Embodiment 1

[0041] a GdF 3 :20%Yb 3+ ,2%Er 3+ A one-step hydrothermal synthesis method for upconversion fluorescent nanorods, comprising the following steps:

[0042] a. Put 0.7g of sodium hydroxide, 7.95mL of oleic acid and 12.66mL of absolute ethanol in a 50mL plastic beaker, stir it magnetically for 20 minutes, and mix it well until a white viscous solution is formed;

[0043] b. Weigh 0.2146g NH 4 F solid, prepare 10mL aqueous solution, add 8.3mL to the mixed solution obtained in step a under magnetic stirring, continue magnetic stirring for about 20 minutes to obtain milky white translucent solution;

[0044] c. Weigh Gd(NO 3 ) 3 ·6H 2 O, Yb(NO 3 ) 3 ·5H 2 O, Er(NO 3 ) 3 ·5H 2 O powder, respectively prepare 0.80M, 0.63M, 0.40M aqueous solutions, respectively take 1.1mL, 0.35mL, 0.05mL into the mixed solution obtained in step b under magnetic stirring, continue magnetic stirring for about 20 minutes until completely dissolved;

[0045] d. Transfer the white suspension pre...

Embodiment 2

[0050] a GdF 3 :30%Yb 3+ ,5%Er 3+ A one-step hydrothermal synthesis method for upconversion fluorescent nanorods, comprising the following steps:

[0051] a. Put 0.7g of sodium hydroxide, 7.95mL of oleic acid and 12.66mL of absolute ethanol in a 50mL plastic beaker, stir it magnetically for 20 minutes, and mix it well until a white viscous solution is formed;

[0052] b. Weigh 0.2146g NH 4 F solid, prepare 10mL aqueous solution, add 8.3mL to the mixed solution obtained in step a under magnetic stirring, continue magnetic stirring for about 20 minutes to obtain milky white translucent solution;

[0053] c. Weigh Gd(NO 3 ) 3 ·6H 2 O, Yb(NO 3 ) 3 ·5H 2 O, Er(NO 3 ) 3 ·5H 2 O powder, respectively prepare 0.71M, 1.03M, 1.20M aqueous solutions, respectively take 1.1mL, 0.35mL, 0.05mL into the mixed solution obtained in step b under magnetic stirring, continue magnetic stirring for about 20 minutes until completely dissolved;

[0054] d. Transfer the white suspension pre...

Embodiment 3

[0059] a GdF 3 :20%Yb 3+ ,1%Er 3+ A one-step hydrothermal synthesis method for upconversion fluorescent nanorods, comprising the following steps:

[0060] a. Put 0.7g of sodium hydroxide, 7.95mL of oleic acid and 12.66mL of absolute ethanol in a 50mL plastic beaker, stir it magnetically for 20 minutes, and mix it well until a white viscous solution is formed;

[0061] b. Weigh 0.2146g NH 4F solid, prepare 10mL aqueous solution, add 8.3mL to the mixed solution obtained in step a under magnetic stirring, continue magnetic stirring for about 20 minutes to obtain a milky white translucent solution;

[0062] c. Weigh Gd(NO 3 ) 3 ·6H 2 O, Yb(NO 3 ) 3 ·5H 2 O, Er(NO 3 ) 3 ·5H 2 O powder, respectively prepare 0.86M, 0.69M, 0.24M aqueous solutions, respectively take 1.1mL, 0.35mL, 0.05mL into the mixed solution obtained in step b under magnetic stirring, continue magnetic stirring for about 20 minutes until completely dissolved;

[0063] d. Transfer the white suspension pr...

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Abstract

The invention discloses a preparation method of GdF3:Yb<3+>,Er<3+> upconversion fluorescent nanorods, wherein the preparation method comprises the following steps: a, mixing sodium hydroxide, oleic acid and absolute ethyl alcohol to form a white viscous solution; b, adding a NH4F solution into the solution while stirring until a semi-transparent solution is formed; c, stirring Gd(NO3)3.6H2O, Yb(NO3)3.5H2O and Er(NO3)3.5H2O solutions while adding the semi-transparent solution, and stirring continuously; d, transferring the liquid prepared in the step c to a polytetrafluoroethylene hydrothermalhigh-pressure reaction kettle, and heating continuously at high temperature; e, after the reaction kettle is cooled, centrifuging, washing and precipitating with cyclohexane and absolute ethyl alcohol, and dissolving the precipitate in cyclohexane; and f, centrifuging the solution obtained in the step e and drying. The structure of nanoparticles and the drug loading area are enriched, and the theoretical and experimental basis is provided for further probe construction and targeted delivery of anticancer drugs.

Description

technical field [0001] The invention relates to the field of luminescent materials, specifically a GdF 3 :Yb 3+ ,Er 3+ Preparation method of upconverting fluorescent nanorods. Background technique [0002] Rare earth-doped upconversion luminescent nanoparticles (UCNPs) are a new class of luminescent materials that can absorb long-wavelength near-infrared photons and emit short-wavelength ultraviolet-visible photons. Compared with traditional down-conversion fluorescent materials such as organic dyes and semiconductor quantum dots, UCNPs have the advantages of high chemical stability, low biological toxicity, strong photostability, narrow emission band, long fluorescence lifetime, no light flickering and photobleaching, etc. Not only that, because the excitation wavelength of UCNPs is in the low-energy near-infrared region, it has little damage to biological tissues and has a deep tissue penetration ability. Therefore, it has shown great applications in the field of biomed...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09K11/85
CPCC09K11/7772
Inventor 王百齐洪恩律高磊李坤萌王智宇张利文张强胡瑞霞
Owner TIANJIN MEDICAL UNIV
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