A kind of nano antibacterial agent and preparation method thereof

A nano-antibacterial agent and antibiotic technology, applied in the field of antibacterial agents and their preparation, can solve the problems of non-targeting, low utilization rate of antibiotics, poor biocompatibility in the field of antibacterial, etc., achieve simple and low-cost raw materials, and improve effective utilization The effect of energy saving and simple synthesis method

Active Publication Date: 2021-03-30
NORTHWEST A & F UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to solve the problems of poor biocompatibility, non-targetability and low utilization rate of antibiotics in the antibacterial field of existing nanomaterial modified antibiotics, and provide a nano antibacterial agent and its preparation method

Method used

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  • A kind of nano antibacterial agent and preparation method thereof
  • A kind of nano antibacterial agent and preparation method thereof
  • A kind of nano antibacterial agent and preparation method thereof

Examples

Experimental program
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Effect test

specific Embodiment approach 1

[0038] Embodiment 1: In this embodiment, a kind of nano antibacterial agent is sodium hyaluronate to modify the surface of the synergistic system of MOF and antibiotics; the synergistic system of MOF and antibiotics is that the antibiotics are encapsulated in the zeolite imidazolate framework material ZIF -8 in.

specific Embodiment approach 2

[0039] Specific embodiment two: the difference between this embodiment and specific embodiment one is: the described zeolite imidazolate framework structure material ZIF-8 is made of Zn(NO) 3 ·6H 2 O provides metal ions, 2-methylimidazole is used as a ligand, and deionized water is used as a dispersion medium, which is formed by cross-linking interaction at room temperature. Other steps are the same as in the first embodiment.

specific Embodiment approach 3

[0040] Embodiment 3: This embodiment differs from Embodiment 1 or Embodiment 2 in that: the antibiotics are tetracycline antibiotics, aminoglycoside antibiotics, lactam antibiotics or polypeptide antibiotics. Other steps are the same as those in Embodiment 1 or 2.

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Abstract

The invention discloses a nano antibacterial agent and a preparation method thereof and relates to an antibacterial agent and a preparation method thereof. The invention aims to solve the problems that the conventional nanometer material modified antibiotics applied to the antibacterial field have poor biocompatibility and do not have targeting property and the utilization rate of the antibioticsis low. The nano antibacterial agent is prepared by performing surface modification on a synergetic system of MOF and antibiotics with sodium hyaluronate, wherein the synergetic system of the MOF andantibiotics with sodium hyaluronate is formed by encapsulating the antibiotics in a zeolite imidazate framework structure material ZIF-8. The method comprises the following steps: 1, preparing the synergetic system of the MOF and antibiotics; 2, performing surface modification on the prepared synergetic system of the MOF and antibiotics with a sodium hyaluronate solution, and performing vacuum drying, thereby obtaining the nano antibacterial agent. According to the preparation method disclosed by the invention, the nano antibacterial agent can be obtained.

Description

technical field [0001] The invention relates to an antibacterial agent and a preparation method thereof. Background technique [0002] Antibiotics, once hailed as "miracle drugs," have long filled many urgent medical needs. But unfortunately, excessive and inappropriate use has led to a sharp increase in the resistance of bacteria to conventional antibiotics. This phenomenon has been the focus of attention and research hotspots at home and abroad. One of the biggest public safety concerns. [0003] Intracellular bacteria refer to pathogenic bacteria that can invade host cells and colonize and reproduce in cells. Intracellular pathogenic bacteria can not only evade the attack of the host immune system, but also to a certain extent be immune to the poisonous effect of antibiotics and other anti-infective drugs, resulting in the aggravation of bacterial drug resistance, and the formation of intracellular lesions will lead to the spread of infection. Recurrent attacks and pro...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/69A61K47/61A61K45/00A61K31/65A61P31/04
CPCA61K31/65A61K45/00A61K47/61A61K47/6923A61P31/04
Inventor 王建龙张旭刘立志黄伦杰张文涛汪蓉王宗汉
Owner NORTHWEST A & F UNIV
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