Oral rehydration salt effervescent tablet and preparation method thereof

Abstract

The invention discloses an oral rehydration salt effervescent tablet and a preparation method thereof. Sodium chloride, potassium chloride, citric acid and anhydrous glucose are used as main active components; sodium bicarbonate, pregelatinized starch, Tween 80 and aspartame are used as auxiliary materials. The oral rehydration salt effervescent tablet is prepared from the following components inpercentage by weight: 5% to 10% of sodium chloride, 2% to 6% of potassium chloride, 3% to 5% of citric acid, 30% to 50% of anhydrous glucose, 2% to 10% of sodium bicarbonate, 6% to 12% of pregelatinized starch, 0.2 to 0.4% of Tween 80 and 0.1 to 0.3% of aspartame. The oral rehydration salt effervescent tablet has the advantages that the effervescent tablet can produce carbon dioxide in water, so that the medicine tablet is quickly disintegrated into small fragments, and the medical components are quickly dissolved; the symptoms of acute and severe patients requiring the medicines to quickly take effect can be timely treated and relieved; the effervescent tablet is especially suitable for the children, the old people and the patients difficulty in taking of pills; the carrying and use are convenient, and the appearance is clear.

Description

technical field [0001] The invention relates to the technical field of oral rehydration salts, in particular to an oral rehydration salt effervescent tablet and a preparation method thereof. Background technique [0002] The development of oral rehydration salts, since 1964 it was found that glucose has the ability to promote the absorption of Na in the gastrointestinal mucosa + It works with water and is widely used clinically to correct dehydration. It has now become one of the first-choice medicines recommended by the World Health Organization for the treatment of diarrhea and dehydration. It was further recommended by the World Health Organization for the treatment of diarrhea caused by cholera, viruses and other causes, and achieved success. Promote applications in more than 90 countries and regions. A large number of clinical practices have proved that the success rate of ORS in correcting dehydration acidosis is more than 95%, and the dehydration correction time is ...

AI Technical Summary

Problems solved by technology

However, the current packaging and dosage form make the use of ORSII (powder) have the following defects: the outer packaging of the powder is packed in aluminum-plastic bags, which are relatively large in size and very inconvenient in transportation and carrying; It cannot be closed again, which is easy to cause pollution, and it is easy to make the remaining powder in the bag come into contact with water during the pouring process, resulting in agglomeration, discoloration, etc. reduce

If the ordinary tablet is dissolved in water and taken, the disintegration speed of the ordinary tablet is too slow, and the excipients used are insoluble in water, making the appearance of the generated rehydration salt solution cloudy

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