3D printing Ti-hydrogel-osteoblast bone tissue engineering support and preparation method thereof

A technology of bone tissue engineering and 3D printing, applied in tissue regeneration, medical science, prosthesis, etc., can solve the problems of allergic reaction, unguaranteed biological safety, tumor causing, etc., and achieve good mechanical properties and good tissue integration. Properties and effects on biosafety
CN108853578AInactive Publication Date: 2018-11-23南京冬尚生物科技有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
南京冬尚生物科技有限公司
Publication Date
2018-11-23
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a 3D printing Ti-hydrogel-osteoblast bone tissue engineering support and a preparation method thereof. The method comprises the following steps of enabling Ti6Al4V powder to beprocessed into a 3D printing Ti support with a porous structure by utilizing SLM technology; then filling a hydrogel-osteoblast mixture in the pores of the 3D printing Ti support under a certain condition so as to prepare a 3D printing Ti-hydrogel-osteoblast bone defect repair support. The support has the advantages that the structure is simple and reliable, the shape and microstructure are controllable, the mechanical property is reliable, the implantation is convenient, the trauma is small, and the cost is low.
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Description

technical field

[0001] The invention belongs to the field of bone tissue repair and reconstruction, and relates to a 3D printed Ti-hydrogel-osteoblast bone tissue engineering scaffold and a preparation method thereof. Background technique

[0002] The repair and reconstruction of bone defects is one of the clinical problems in orthopedics. It is well known that autogenous bone is considered the gold standard for bone grafting, but its source is limited and may lead to complications such as necrosis of the supply site, postoperative chronic pain, allergic reaction, and infection. While allograft bone and xenograft bone are widely used because they come from a wide range of sources and do not require additional surgical operations, but there are also complications such as slow integration and remodeling, immune rejection, and disease transmission, especially reducing the osteoinductive and osteoconductive.

[0003] At present, scaffold materials include bioactive calcium pho...

Claims

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