Synthesis method of hypericin

Abstract

The invention discloses a synthesis method of hypericin. JSTS-1 is dissolved into acetic acid; stannous chloride is dripped; heating reflux is performed; cooling is performed to room temperature; suction filtering and drying are performed; the material is dissolved into a mixed solvent of pyridine and piperidine; ferrous sulfate heptahydrate pyridine nitric oxide is added; replacement nitrogen gasprotection is performed; heating reaction is performed under light shielding; cooling and reduced pressure rotary drying are performed; diluted hydrochloric acid is added for stirring; suction filtering is performed; filter cake is washed by water to reach a neutral state; the filter cake is dissolved into methyl alcohol; silica gel is added; reduced pressure rotary drying is performed; column chromatography separation is performed; products are added into acetone; low-temperature illumination and vacuum rotary drying are performed; methyl alcohol is added; stirring heating is performed; then, active carbon is added; stirring is performed; suction filtering, mother liquid rotary drying, water addition stirring, and suction filtering are performed; water washing is performed until the mother liquid is clear; solid is scraped out; dichloromethane is added; stirring and suction filtering are performed; dichloromethane is washed until the mother liquid is clear; solid is dried; a target product is obtained. The synthesis method provided by the invention has the advantages that the synthesis route is simple; the purification difficulty is low; the total yield exceeds 60 percent; the synthesis method is suitable for industrialization.

Description

technical field [0001] The invention relates to the field of chemical synthesis, in particular to a method for synthesizing hypericin. Background technique [0002] After several centuries of application and a large number of clinical trials, Hypericum Yee has confirmed its safety and effectiveness, which has attracted the attention of the medical community, and its demand is increasing day by day. From the perspective of application in Europe, both antidepressant preparations and external preparations are used in large dosages. According to statistics, there are 100 million patients in the world, and the dosage is extremely large. It can be seen that the untapped domestic and global markets have huge potential and are worthy of in-depth research and introduction to the market. Moreover, AIDS is rampant in the world, but there are not many treatment methods and drugs. The United States has developed a small amount of drugs, but monopolizes the patents. Chinese researchers ...

AI Technical Summary

Problems solved by technology

At present, most of the existing methods in China stay on the extraction method of hypericin, and there are few studies on the methods of its separation and purification.

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