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Application of phenylpyruvate in the preparation of immune enhancer

A technology of phenylpyruvate and pharmacy, which is applied in the application field of phenylpyruvate in the preparation of immune enhancers, can solve problems such as adverse effects, and achieve the effects of less addition, high physiological activity, and no adverse side effects

Active Publication Date: 2021-05-25
SOUTH CHINA AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The technical problem to be solved in the present invention is to overcome the adverse effects of the current mainstream market drugs for improving immunity levels, to provide a new application of phenylpyruvate as an immune enhancer, and to broaden the scope of application of phenylpyruvate, in order to apply phenylpyruvate Provide reference in the field of clinical immunotherapy

Method used

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  • Application of phenylpyruvate in the preparation of immune enhancer
  • Application of phenylpyruvate in the preparation of immune enhancer
  • Application of phenylpyruvate in the preparation of immune enhancer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Example 1 The effect of adding phenylpyruvate on the phagocytic ability of mouse peritoneal macrophages in common diet

[0050] 1. Experimental method

[0051]In order to study the effect of phenylpyruvate on the immune function of mice, C57BL / 6J male mice were used as the research object, divided into 3 groups (1 control group and 2 treatment groups), reared in a single cage, and the number of repetitions was 8 , fed the mice with common diets supplemented with 0% (control group), 0.2% and 0.4% phenylpyruvate, respectively, and carried out the test of phagocytosis of Escherichia coli in vitro by mouse peritoneal macrophages after 6 weeks. Specific steps include:

[0052] (1) Collection of primary mouse peritoneal macrophages: Wipe the operation table and pipette gun with alcohol cotton to prevent contamination by bacteria. Filter the HBSS (Hank's Balanced Salt Solution, Hank's Balanced Salt Solution) solution with 5% serum for later use, kill the mice by neck disloca...

Embodiment 2

[0057] Example 2 Effect of Adding Phenylpyruvic Acid to Common Diet on Mouse Spleen Lymphocyte Proliferation

[0058] 1. Experimental method

[0059] In order to further study the effect of phenylpyruvate on the immune function of mice, C57BL / 6J male mice were used as the research object, divided into 3 groups (control group and 2 treatment groups), reared in a single cage, and the number of repetitions was 8 , fed the mice with common diets supplemented with 0% (control group), 0.1% and 0.2% phenylpyruvate, respectively, and carried out spleen lymphocyte proliferation test after 6 weeks. Specific steps include:

[0060] (1) After the mice were killed by neck dislocation, they were soaked in bromogeramine solution until they were soaked, and then they were taken out. The spleens of the mice were dissected, separated, transferred to a small beaker containing a small amount of Hanks solution, washed for 2 to 3 times, and then placed in On the cell sieve in the plate, use a gri...

Embodiment 3

[0065] Example 3 Common Diet Added Phenylpyruvate to the Effect of Mice on Wound Healing Ability

[0066] 1. In this experiment, by studying the effect of phenylpyruvate on tail wound healing of mice, it is used to illustrate the change of phenylpyruvate on the immune function. The specific test method is:

[0067] (1) In the experiment, C57BL / 6J male mice were used as the research object, divided into 3 groups (control group and 2 treatment groups), reared in a single cage, and the number of repetitions was 8. Added 0% (control group), 0.2 % and 0.4% phenylpyruvate were fed to mice in normal diet.

[0068] (2) Subtract the tissues 1mm away from the tail tip of the mice in the two treatment groups and the control group. In order to ensure that the wound surface of the tail tip of each mouse is as similar as possible, the scissors are cut perpendicular to the cut surface to form an incision wound. And the wound is disinfected with iodine and alcohol after the wound is formed....

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Abstract

The invention discloses the application of phenylpyruvate in the preparation of immune enhancer. The present invention provides phenylpyruvate or a pharmaceutically acceptable salt thereof, or a prodrug of phenylpyruvate in the preparation of an immune enhancer, or in the preparation of a product that enhances macrophage phagocytosis and / or promotes lymphocyte proliferation, or in the preparation of Novel applications in the preparation of products that promote wound healing. The present invention finds that adding phenylpyruvate to the common diet of mice can significantly improve the immunity level of mice and promote wound healing, and the addition of phenylpyruvate is less, so it can be directly added to animal drinking water, feed, and medicines. It has the advantages of being safe, effective, and will not cause toxic and side effects, and can be used for patients with low immune function; it can be used as an immune adjuvant in therapeutic vaccines; it can be used as an immune enhancer in wound healing, immunodeficiency and other treatments. The acid provides a basis as an immune adjuvant and has a good prospect for popularization and application.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations. More specifically, it relates to the application of phenylpyruvate in the preparation of immune enhancer. Background technique [0002] The body's immunity is an important ability for the human body to defend against pathogenic invasion and disease. If the immune system, which is the line of health defense, is damaged, it may lead to low immunity, making the human body susceptible to pathogenic infection, various chronic diseases or cancer, mental retardation, slowed healing of windows, and even accelerated aging process. In recent years, with the intensification of economic globalization, the pace of human life has been accelerating. Due to factors such as long-term fatigue work, increased psychological pressure, and irregular life, the number of people with low immunity is increasing year by year. . According to China's big health data in 2015, the cost of treating cardio...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/192A61P17/02A61P37/04A23K20/111A23L33/10
CPCA23V2002/00A61K31/192A23K20/111A23L33/10A61P17/02A61P37/04A23V2200/324A23V2250/02
Inventor 束刚江青艳廖正睿朱晓彤王丽娜王松波袁业现余璐璐
Owner SOUTH CHINA AGRI UNIV
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