44 results about "Propiophenones" patented technology

The invention discloses a preparation method of conductive hydrogel based on two liquid metals, which comprises the following steps: by taking 2-acryloyloxyethyl trimethyl ammonium chloride (AETAC) as a monomer, N, N '-methylenebisacrylamide (MBA) as a cross-linking agent and 2-hydroxy-2-methyl propiophenone (HMPP) as a photoinitiator, and combining with eutectic gallium indium (EGaIn) and eutectic gallium indium tin (EGaInSn) liquid metals, preparing the conductive hydrogel based on the two liquid metals. Two different conductive hydrogels are prepared through ultrasonic dispersion and ultraviolet-initiated polymerization. The method is simple in process, and the obtained hydrogel has high conductivity, good mechanical property and biocompatibility and can be widely applied to the fields of flexible electronics, biomedical sensing, wearable equipment and the like.

The invention relates to a super-amphiphobic coating with a dual self-repairing function and a preparation method of the super-amphiphobic coating. According to the super-amphiphobic coating, crack self-repairing is achieved through dynamic disulfide bonds, and low-surface-energy substance self-repairing is achieved through microcapsules. The preparation method comprises the following steps: firstly, modifying hydroxyl-terminated polydimethylsiloxane by using an isocyanate prepolymer containing disulfide bonds, then modifying TiO2 nanoparticles by using 3-aminopropyltriethoxysilane and octadecyltrimethoxysilane, and preparing a microcapsule which takes polyamide as a shell and perfluorooctyltriethoxysilane as a core material, and finally, carrying out ball-milling mixing on the disulfide bond-containing polyurethane modified organic silicon resin, the modified TiO nanoparticles, microcapsules and 2-hydroxy-2-methyl propiophenone, and spraying the mixture on the surface of a base material to obtain the super-amphiphobic coating with the dual self-repairing function. According to the super-amphiphobic coating with the dual self-repairing function and the preparation technology thereof, the coating achieves high durability through dual self-repairing, and the hydrophobic and oleophobic performance is high.

The invention provides a high-strength fire-resistant cable and a preparation method thereof, and belongs to the technical field of cables, and the preparation method of the high-strength fire-resistant cable comprises the following steps: reacting nano-hydroxyapatite with 10-(2-methacryloyloxy) monodecyl phosphate in ethanol, and drying to obtain modified hydroxyapatite; ethylene-vinyl acetate copolymer, magnesium hydroxide, zinc borate, zinc stannate, polyethylene wax, vinyltrimethoxysilane, 2-hydroxy-2-methyl propiophenone and modified hydroxyapatite are mixed, melt-extruded and illuminated at constant temperature, and a sheath layer is obtained; mixing tetraethoxysilane, ethanol, dibutyltin dilaurate, fumed silica, phlogopite paper and glass fibers, heating and aging, and cutting to obtain a fireproof layer; the insulating layer, the fireproof layer and the sheath layer are sequentially coated on the conductor to prepare the high-strength fireproof cable, and the cable prepared by the invention has good mechanical property, electrical insulating property and fireproof property.

The application relates to the technical field of high polymer materials, in particular to ammonia-removing and humidity-controlling water gel as well as a preparation method and application thereof, which comprises the following raw materials: deionized water, AM, MBA, Gly, lithium chloride, 2-hydroxy-2-methyl propiophenone, magnesium chloride or magnesium oxide; the AM and the MBA are added into the deionized water, and polymerization is initiated by 2-hydroxy-2-methyl propiophenone and ultraviolet light to form a polyacrylamide network, so that the novel water gel can stably control humidity and effectively remove ammonia in long-term storage, effectively adsorb ammonia and provide molecular-level water molecules, and the required humidity of a cigar is maintained; secondly, the MBA is added into the water gel to form a more stable and porous three-dimensional crosslinking network, which can not only adjust the moisture absorption / relaxation rate of the water gel, realize humidity buffering, but also adsorb ammonia molecules through acid-base neutralization, ion exchange, hydrogen bonding, electrostatic interaction, so that the water gel can maintain the required humidity of the cigar for a long time and reduce the volatilization of ammonia.

The invention belongs to the technical field of functional three-dimensional composite material preparation, and particularly relates to ion-modified carrageenan-polyacrylamide composite hydrogel and a preparation method thereof.The preparation method comprises the following steps that S1, carrageenan, acrylamide and N, N-dimethylformamide are mixed and stirred to be uniform, and a mixture is obtained; the preparation method comprises the following steps: dispersing and dissolving carrageenan, polyacrylamide, N, N '-methylene bisacrylamide and 2-hydroxy-4'-(2-hydroxyethoxy)-2-methyl propiophenone in deionized water, and heating and stirring until solids are completely dissolved to obtain a carrageenan-polyacrylamide hydrogel prepolymer solution, namely a CA-PAM hydrogel prepolymer solution; s2, transferring the CA-PAM hydrogel pre-polymerized liquid into a watch glass, and refrigerating the CA-PAM hydrogel pre-polymerized liquid in an environment of 4 DEG C until the CA-PAM hydrogel pre-polymerized liquid is solidified to obtain a condensate; s3, irradiating the cured product by using an ultraviolet lamp, so as to prepare carrageenan-polyacrylamide composite hydrogel; s4, the carrageenan-polyacrylamide composite hydrogel is soaked in chlorate solutions with different concentrations respectively, and the ion modified / carrageenan-polyacrylamide composite hydrogel material is prepared.

The invention discloses a solvent-participation-free synthesis process of p-ethyl propiophenone, which comprises the following steps: by taking ethylbenzene and propionyl chloride as raw materials and phosphorus trichloride and lewis acid as catalysts, carrying out Friedel-Crafts acylation reaction without adding other reaction solvents to obtain the p-ethyl propiophenone. Compared with the prior art, the method has the advantages that the generation of disubstituted impurity 1-(2, 4-diethyl phenyl) propan-1-ketone is unexpectedly and effectively avoided, the impurity generation amount is less than 5%, the yield and the purity of p-ethyl propiophenone are greatly improved, and the synthesis process is green, environment-friendly, low in cost and convenient for realizing industrial production, and can be used for industrial production of eperisone.

The invention belongs to the technical field of adhesive materials, and particularly relates to a power-on viscosity-reducing adhesive tape capable of resisting precipitation of a plasticizer and a preparation method of the power-on viscosity-reducing adhesive tape. The invention provides a preparation method of an electrified viscosity-reducing adhesive tape capable of resisting precipitation of a plasticizer. The preparation method comprises the following steps: S1, stirring and mixing 30-40 parts of modified polyethylene glycol diacrylate, 30-40 parts of urethane acrylate, 4-8 parts of montmorillonite, 2-4 parts of 2-hydroxy-2-methyl propiophenone, 1-3 parts of the plasticizer and 1-3 parts of an antioxidant to obtain a mixture; and S2, coating a release film with the mixture by using a blade coating machine, carrying out UV curing for 60-80 seconds to obtain an adhesive layer, and then laminating a protective film on the adhesive layer to obtain the electrified viscosity-reducing adhesive tape capable of resisting the precipitation of the plasticizer. The adhesive tape disclosed by the invention has a good power-on visbreaking effect, and meanwhile, the situation of adhesive residue after power-on can be avoided.

The present invention aims to provide a novel B0AT1 inhibitor. [Solution] The present invention relates to a compound represented by formula (I) or a salt thereof that has an inhibitory effect on B0AT1. The present invention also relates to a B0AT1 inhibitor containing the compound, and a pharmaceutical composition containing the compound. One embodiment of the present invention is a pharmaceutical suitable for the prevention and / or treatment of amino acid metabolic disorders such as phenylketonuria, urea cycle disorders, hypertyrosinemia (types 1-3), hypermethioninemia, maple syrup urine disease, homocystinuria, nonketotic hyperglycinemia, propionic acidemia, methylmalonic acidemia, and isovaleric acidemia. In the formula, each symbol is as described in the specification. [C1] JPEG2026137794000308.jpg32170

The invention belongs to the technical field of building material admixtures and relates to a water-reducing hydrated calcium silicate composite early strength agent as well as a preparation method and application thereof. Wherein the polycarboxylic acid water reducer comprises the following components: acrylic acid, methallyl alcohol polyoxyethylene ether, mercaptoacetic acid and 2-hydroxy-4 '-(2-hydroxyethoxy)-2-methyl propiophenone, and the molar ratio of the acrylic acid to the methallyl alcohol polyoxyethylene ether is (5-7): 1; the mercaptoacetic acid accounts for 0.8%-1.6% of the total mole number of the acrylic acid, and the 2-hydroxy-4 '-(2-hydroxyethoxy)-2-methyl propiophenone accounts for 0.84%-0.85% of the total mole number of the methallyl alcohol polyoxyethylene ether. According to the invention, the molecular structure of PCE is accurately designed, and PCE is used as a key regulating agent to actively regulate the nucleation process of C-S-H and the steric hindrance effect among particles, so that the aggregation tendency of the particles is inhibited, the small particle size of the product is ensured, and the long-term dispersion stability is given to the product.

The invention belongs to the technical field of organic synthesis, and relates to a synthesis method of an alcohol compound, which comprises the following steps: in the presence of a ruthenium-based hydrogenation catalyst, carrying out hydrogenation reaction on a carbonyl-containing compound to obtain the alcohol compound, the ruthenium-based hydrogenation catalyst comprises an active metal, an auxiliary metal, a ligand and a carrier, the active metal is ruthenium; the auxiliary metal is one or more of iron, nickel, zinc and molybdenum; the ligand is a triazole ligand; the carrier is MOFs (Metal Organic Frameworks) of MIL series. The ruthenium-based hydrogenation catalyst can be used for efficiently catalyzing p-methoxypropiophenone hydrogenation to prepare 1-(4-methoxyphenyl) propanol under proper reaction conditions, so that the problems of low conversion rate, more side reactions, high catalyst cost and the like in the prior art are solved, and the ruthenium-based hydrogenation catalyst has the advantages of high yield, high selectivity and the like.

The application belongs to the technical field of organic synthesis, and particularly relates to a preparation method of 4-bromocyclopropylbenzene. The method comprises the following steps: in step 1, bromobenzene, a Lewis acid and 3-chloropropionyl chloride are reacted to obtain 4-bromo-3-chloropropiophenone; in step 2, 4-bromo-3-chloropropiophenone and a reducing agent are reacted to obtain 4-bromochloropropylbenzene; and in step 3, 4-bromochloropropylbenzene is reacted under the action of an alkali catalyst to obtain 4-bromocyclopropylbenzene. The method has the advantages that common reagents are used in each step, the cost of raw materials is low, the synthesis process is short, the yield is high, there is no harsh reaction condition, the method is safe, convenient to operate, friendly to the environment, suitable for large-scale industrial production, and has a good application prospect.

The invention belongs to the technical field of chemical synthesis, and particularly relates to a synthetic method of butylphenylmorpholine, which comprises the following steps of: reacting tert-butylbenzene with propionyl chloride to obtain tert-butylpropiophenone, reacting the product with cis-2, 6-dimethylmorpholine and paraformaldehyde to obtain 4-tert-butyl-1-(2-methyl-1-oxy-3-(cis-2, 6-dimethylmorpholine-4-) propyl) benzene, and reacting the 4-tert-butyl-1-(2-methyl-1-oxy-3-(cis-2, 6-dimethylmorpholine-4-) propyl) benzene with the product to obtain the butylphenylmorpholine. And reducing hydrogen under the action of a catalyst to obtain the butylphenylmorpholine. By optimizing a raw material route and process conditions, the defects of high cost, low purity and dependence on an acid-binding agent in the prior art are overcome, special equipment is not needed, and the method is suitable for industrial continuous production.

The present invention discloses a synthesis process of 1,3-dihydroxy-1-(4-methylsulfonylphenyl)propanone, which comprises the following steps: (1) Under the action of a Lewis base, 4-methylsulfonylbenzaldehyde and methyl acrylate are reacted to obtain intermediate III; (2) Under the action of imidazole, intermediate III undergoes a hydroxyl protection reaction with TBSCl to obtain compound IV; (3) Compound IV undergoes an ester group reduction reaction with DIBAL-H to obtain compound V; (4) Under the action of imidazole, compound V undergoes a hydroxyl protection reaction with TBSCl to obtain compound VI; (5) Compound VI undergoes an oxidation reaction under the action of ozone to obtain compound II; (6) Compound II is deprotected under acidic conditions to obtain compound I, namely the said 1,3-dihydroxy-1-(4-methylsulfonylphenyl)propanone. This method improves the yield of the product, and the post-treatment is simple, making it more suitable for practical applications.

In a method for preparing a keto acid, an enzymatic reaction is carried out by using glycine and an alcoholic organic substance as substrates; the alcoholic organic substance is converted into an aldehyde organic substance, glycine and the aldehyde organic substance are converted into a β-hydroxy-α-amino acid, and then the β-hydroxy-α-amino acid is converted into a keto acid. The preparation method for a keto acid can also be used in the preparation of amino acids. The number of enzymes used is much less than that of enzymes used in a natural synthesis route, so that the production cost is low. An artificial metabolism platform for keto acids is established and can produce multiple important keto acids, such as phenylpyruvic acid, 4-methyl-2-oxopentanoic acid, pyruvic acid and 2-oxo-butyric acid.

The invention discloses carbonyl reductase and application of a mutant thereof in preparation of a atomoxetine chiral intermediate. The carbonyl reductase and the mutant thereof have a sequence as shown in SEQ ID NO: 1, 3, 5, 7, 9, 11, 13, 15, 17, 19 or 33. According to the carbonyl reductase disclosed by the invention, the reaction conversion rate of the carbonyl reductase for generating (S)-3-chlorobenzene propanol from 3-chloropropiophenone reaches 99%, the optical purity is greater than 99%, and the carbonyl reductase shows excellent catalytic effect and conversion efficiency. The method based on the enzyme and the mutant is mild in reaction condition and environmentally friendly, has high regioselectivity and stereoselectivity, avoids chiral resolution and heavy metal residues in products, makes up for the defects of chemical methods, and has wide application prospects and high market value.

The invention provides a quinoline derivative compound as well as a preparation method and application thereof. The structural formula of the quinoline derivative compound is shown in the specification. The quinoline derivative compound shows remarkable safener activity at a low application dosage, can effectively relieve phytotoxicity of herbicides to crops, shows a good detoxification effect, and remarkably promotes growth recovery of the crops. Compared with existing safeners such as cyclopropanesulfonamide and the like, the quinoline derivative compound disclosed by the invention has higher safety and more excellent detoxification efficiency, particularly has an outstanding relieving effect on crop phytotoxicity caused by p-hydroxyphenylpyruvate dioxidase inhibition herbicides, and can guarantee normal growth and development of crops.

The application discloses an ion conductive hydrogel and a preparation method and application thereof, relates to the technical field of functional hydrogel and sensors, and discloses the ion conductive hydrogel which comprises a gel-forming monomer, a crosslinking agent, an inorganic salt and a photoinitiator; the gel-forming monomer comprises acrylamide and zwitterionic monomer sulfobetaine methacrylate; the crosslinking agent is N, N'-methylene bisacrylamide; the photoinitiator is 2-hydroxy-4'-(2-hydroxyethoxy)-2-methylpropiophenone; and the solvent is deionized water. Based on the ion conductive hydrogel, an ion conductive hydrogel electrode patch can be prepared; by means of a wearable device, the ion conductive hydrogel electrode patch can be adhered to a human heart part, safe and comfortable heart rate variability data acquisition of the human body can be realized, and then the detection of CAN can be realized.

The application belongs to the technical field of adhesive materials, and particularly relates to an anti-plasticizer-outcoming power-on adhesion-reducing adhesive tape and a preparation method thereof. The application provides a preparation method of the anti-plasticizer-outcoming power-on adhesion-reducing adhesive tape, which comprises the following steps: S1, stirring and mixing 30-40 parts of modified polyethylene glycol diacrylate, 30-40 parts of polyurethane acrylate, 4-8 parts of montmorillonite, 2-4 parts of 2-hydroxy-2-methylpropiophenone, 1-3 parts of a plasticizer and 1-3 parts of an antioxidant to obtain a mixture; S2, coating the mixture on a release film by using a doctor blade coater, UV curing for 60-80 s to obtain an adhesive layer, and then attaching a protective film to the adhesive layer to obtain the anti-plasticizer-outcoming power-on adhesion-reducing adhesive tape. The adhesive tape has good power-on adhesion-reducing effect, and can avoid the occurrence of residual glue after power-on.

The invention belongs to the technical field of coatings, and particularly relates to a low-temperature self-repairing anti-frost coating and a preparation method and application thereof.The low-temperature self-repairing anti-frost coating is formed by free radical copolymerization of sulfobetaine methacrylate, hydroxyethyl methacrylate, N, N '-methylene bisacrylamide, boric acid and 2-hydroxy-4'-(2-hydroxyethoxy)-2-methyl propiophenone; wherein the sulfobetaine methacrylate forms a dynamic physical crosslinking point through strong hydration of a zwitterionic structure, and the hydroxyethyl methacrylate enhances the rigidity of the polymer through a hydrogen bond network. Compared with the prior art, the low-temperature frost-resistant coating solves the problems that a conventional low-temperature frost-resistant coating in the prior art does not have a self-repairing function, and the low-temperature frost-resistant coating with the self-repairing function cannot be self-repaired in a low-temperature environment. According to the scheme, a self-repairing function is realized at a lower environment temperature (-20 DEG C), and a long-term frost-resistant solution is provided for equipment which continuously works in a low-temperature environment.

The invention is applied to the technical field of medicines, and discloses a synthesis method of a medicine, namely, triphenhydrochlor, for treating Parkinson's disease, which comprises the following steps: S1, taking tetrahydrofuran as a solvent, taking chlorocyclohexane and magnesium powder as raw materials, adding anhydrous lithium chloride as a catalyst, initiating a reaction by using iodine, and performing suction filtration to obtain triphenhydrochlor; preparing a tetrahydrofuran solution of Grignard reagent cyclohexylmagnesium chloride lithium chloride; s2, dissolving propiophenone piperidine hydrochloride in tetrahydrofuran, and slowly dropwise adding into the Grignard reagent obtained in S1 for reaction; and S3, after the reaction is completed, adding diluted hydrochloric acid to terminate the reaction, and separating out the triphenil hydrochloride. According to the synthesis method of the medicine, namely, the triphenhydrochlor hydrochloride, for treating the Parkinson's disease, an anhydrous lithium chloride catalytic system is introduced, so that initiation conditions of a Grignard reaction are remarkably optimized, efficient preparation of a Grignard reagent at normal temperature is realized, the problems of high energy consumption and potential safety hazards caused by a high-temperature reaction in the prior art are avoided, the reaction process is easier to control, and the yield is higher. And the safety of the production process is greatly improved.

The invention relates to a thermoplastic modified organic silicon material as well as a preparation method and application thereof, and the thermoplastic modified organic silicon material comprises the following raw material components in parts by weight: 10-15 parts of an organic silicon polymer containing disulfide bonds, 40-70 parts of an acrylate monomer and 0.5-1.5 parts of a photoinitiator, the disulfide bond-containing organosilicon polymer is obtained by reacting a disulfide bond-containing silane coupling agent with an organosilicon polymer, and the mass ratio of the disulfide bond-containing silane coupling agent to the organosilicon polymer is 1: (1.6-2); the photoinitiator is at least one of 2-hydroxy-2-methyl-1-phenyl-1-acetone or 2-hydroxy-4 '-(2-hydroxyethoxy)-2-methyl propiophenone, and the photoinitiator is at least one of 2-hydroxy-2-methyl-1-phenyl-1-acetone and 2-hydroxy-4'-(2-hydroxyethoxy)-2-methyl propiophenone. In the presence of a specific photoinitiator, an acrylate monomer is subjected to an in-situ photopolymerization reaction on the surface of the organosilicon polymer containing disulfide bonds, so that the thermoplastic modified organosilicon material has thermoplastic capability.

The invention relates to the technical field of coating protection, in particular to a composite protective coating as well as a preparation method and application thereof. The invention provides a composite protective coating. The composite protective coating comprises a photopolymerization precursor mixed solution, graphene oxide and a nitrogen-doped carbon-coated cobalt-doped cadmium sulfide composite nanomaterial, the photopolymerization precursor mixed solution is prepared from triethylene glycol dimethacrylate, 3, 4-epoxycyclohexyl methyl-3, 4-epoxycyclohexyl formate, 2-hydroxy-2-methyl propiophenone and carbonic acid acetate, and the photopolymerization precursor mixed solution is prepared from the following raw materials: triethylene glycol dimethacrylate, 3, 4-epoxycyclohexyl methyl-3, 4-epoxycyclohexyl formate, 2-hydroxy-2-methyl propiophenone and carbonic acid acetate. A protective coating prepared from the composite protective paint has high corrosion resistance and weather resistance.

The invention belongs to the field of biomedical engineering, and discloses a magnetic-thermal double-response hydrogel embolism coil capable of being used for enhancing aneurysm embolism through magnetic guidance and a preparation method and an application method of the magnetic-thermal double-response hydrogel embolism coil. The preparation method comprises the following steps: by taking pentaerythritol tetraacrylate as a cross-linking agent and 2-hydroxy-4 '-(2-hydroxyethoxy)-2-methyl propiophenone as a free radical initiator, adding a thickening and dispersing aid and magnetic nanoparticles, and carrying out free radical polymerization reaction under ultraviolet irradiation, thereby obtaining the magnetic nano-composite material. The magnetic-thermal dual-response hydrogel embolism coil is in a glassy state below room temperature and is used for straightening and stably passing through the micro catheter; and the magnetic-thermal dual-response hydrogel embolism coil recovers to a preset shape when the temperature rises to the body temperature, and is used for realizing an embolism structure of the bag-shaped space. According to the invention, the packing density is obviously improved.

A herbicidal composition and a method for controlling weeds, including one or more uracil compounds of formula (I) and a compound of formula (II), and a herbicide compound of group B and a safener of group C. A weight ratio of the uracil compounds to the herbicide compound group B and the safener group C is 1:0.02 to 1:50, and the herbicide compound of group B is one or more of compounds B-1 to B-12: B-1, acetolactate synthase inhibitors; B-2, acetyl CoA carboxylase inhibitors; B-3, protoporphyrinogen IX oxidase inhibitors; B-4, 4-hydrophenylpyrubic acid dioxygenase inhibitors; B-5, phytoene desaturase inhibitors; B-6, photosystem II inhibitors; B-7, very-long-chain fatty acid synthesis inhibitors; B-8, microtubule formation inhibitors; B-9, auxin-type herbicides; B-10, enolpyruvylshikimate-3-phosphate synthase inhibitors; B-11, glutamine synthase inhibitors; and B-12, other herbicides; or agriculturally acceptable salts or derivatives thereof

The invention discloses a preparation method of famotidine and relates to the technical field of drug preparation. The present invention adopts famotidine crude product as raw material, and carries out three recrystallizations in stages, and selects recrystallization liquid A including 10-15% N,N-dimethylformamide, 5-12% dimethyl sulfoxide, 1-3% succinic acid, and the balance being purified water, and recrystallization liquid B including 20-25% linolenic acid, 8-15% N,N-dimethylformamide, 2-5% citric acid, 0.5-1% di-tert-butyl dicarbonate, and the balance being purified water, and recrystallization liquid C including 15-30% methanol, 5-10% p-ethylpropiophenone, 1-5% paraformaldehyde, and the balance being purified water, and the final famotidine finished product has high purity, high yield, and N-nitrosodimethylamine content of 0, is suitable for large-scale production, and has high economic value.

The invention relates to preparation of resin, in particular to nanowire array modified acrylate light-cured resin. A commercial photoinitiator 2-hydroxy-2-methyl propiophenone (PI-1173) is mainly introduced into a copper nanowire wrapped by rhenium, zirconium and iron, so that the contact area of the photoinitiator and resin is increased. Re, Zr and Fe on the prepared nanowire array have a synergistic effect, the dispersity of nanoparticles in the epoxy acrylate resin is remarkably improved, and the mechanical property of the acrylic light-cured resin is greatly improved through the combined effect of the two-dimensional layered graphene and the nanowires.

Solid forms of (3aR)-1, 3a, 8-trimethyl-1, 2, 3, 3a, 8, 8a-hexahydropyrrolo (2, 3-b) indol-5-yl phenyl-carbamate tartrate, including crystalline (3aR)-1, 3a, 8-trimethyl-1, 2, 3, 3a, 8, 8a-hexahydropyrrolo (2, 3-b) indol-5-yl phenyl-carbamate tartrate (posiphen D-tartrate Form A), crystalline (3aR)-1, 3a, 8-trimethyl-1, 2, 3, 3a, 8, 8a-hexahydropyrrolo (2, 3-b) indol-5-yl phenyl-carbamate tartrate dihydrate (posiphen D-tartrate Form B), crystalline (3aR)-1, 3a, 8-trimethyl-1, 2, 3, 3a, 8, 8a-hexahydropyrrolo (2, 3-b) indol-5-yl phenyl-carbamate tartrate Form A having the peak of Pattern C (posiphen D-tartrate Form A+Pattern C), and amorphous (3aR)-1, 3a, 8-trimethyl-1, 2, 3, 3a, 8, 8a-hexahydropyrrolo (2, 3-b) indol-5-yl phenyl-carbamate tartrate, are disclosed. Pharmaceutical compositions comprising posiphen D-tartrate Form A, posiphen D-tartrate Form B, posiphen D-tartrate Form A having the peaks of Pattern C, and amorphous posiphen D-tartrate, and methods of treating various conditions by administering these solid forms, are also disclosed.

The invention relates to the technical field of bioengineering, in particular to a ketoreductase mutant as well as a preparation method and application thereof. The ketoreductase cgKR1 derived from candida glabrata is mutated to obtain a ketoreductase mutant, and the ketoreductase mutant is applied to preparation of (R)-3-chloro-1-phenyl-propanol by reducing 3-chloropropiophenone, and compared with wild type ketoreductase cgKR1, the yield of the (R)-3-chloro-1-phenyl-propanol is increased, and the yield of the (R)-3-chloro-1-phenyl-propanol is increased. The ketoreductase mutant provided by the invention has higher enzyme activity and stereoselectivity on the reduction reaction of 3-chloropropiophenone, the isomer purity of a reaction product is greatly improved, and industrial production requirements can be better met.

To provide a pharmaceutical product that has B0AT1 inhibitory activity. [Solution] The present invention is based on formula (I): [C1] TIFF2026066243000332.tif44170 [In the formula, each symbol is as described in the specification.] The present invention relates to a pharmaceutical composition containing a compound represented by or a salt thereof, and a B0AT1 inhibitor. One embodiment of the present invention is a pharmaceutical suitable for the prevention and / or treatment of amino acid metabolic disorders such as phenylketonuria, urea cycle disorders, hypertyrosinemia (types 1-3), hypermethioninemia, maple syrup urine disease, homocystinuria, nonketotic hyperglycinemia, propionic acidemia, methylmalonic acidemia, and isovaleric acidemia.

The invention relates to the technical field of optical cement, and discloses low-dielectric OCA optical cement. Comprising the following raw materials in parts by weight: 20 to 30 parts of hydroxy acrylic resin, 10 to 20 parts of polyvinyl alcohol, 10 to 30 parts of polyurethane acrylate resin, 8 to 12 parts of epoxy acrylate oligomer, 10 to 30 parts of hydroxyethyl methylacrylate, 8 to 16 parts of butyl acrylate, 0.5 to 1 part of propiophenone, 0.1 to 0.3 part of benzoyl methyl ether, 0.5 to 2 parts of a coupling agent, 2 to 4 parts of a cross-linking agent, 0.5 to 1 part of an antioxidant and 4 to 8 parts of polyethylene. 1-3 parts of superconductive polypropylene and 3-6 parts of silver nanowires. The hydroxyl acrylic resin and the cross-linking agent form a high-density cross-linked network to improve the cohesive strength, so that the problem that the bonding requirement cannot be met due to the fact that the laying thickness of the traditional low-dielectric OCA optical cement is reduced but the bonding property is influenced is solved.