21 results about "Propiophenones" patented technology

The invention provides a high-strength fire-resistant cable and a preparation method thereof, and belongs to the technical field of cables, and the preparation method of the high-strength fire-resistant cable comprises the following steps: reacting nano-hydroxyapatite with 10-(2-methacryloyloxy) monodecyl phosphate in ethanol, and drying to obtain modified hydroxyapatite; ethylene-vinyl acetate copolymer, magnesium hydroxide, zinc borate, zinc stannate, polyethylene wax, vinyltrimethoxysilane, 2-hydroxy-2-methyl propiophenone and modified hydroxyapatite are mixed, melt-extruded and illuminated at constant temperature, and a sheath layer is obtained; mixing tetraethoxysilane, ethanol, dibutyltin dilaurate, fumed silica, phlogopite paper and glass fibers, heating and aging, and cutting to obtain a fireproof layer; the insulating layer, the fireproof layer and the sheath layer are sequentially coated on the conductor to prepare the high-strength fireproof cable, and the cable prepared by the invention has good mechanical property, electrical insulating property and fireproof property.

The application relates to the technical field of high polymer materials, in particular to ammonia-removing and humidity-controlling water gel as well as a preparation method and application thereof, which comprises the following raw materials: deionized water, AM, MBA, Gly, lithium chloride, 2-hydroxy-2-methyl propiophenone, magnesium chloride or magnesium oxide; the AM and the MBA are added into the deionized water, and polymerization is initiated by 2-hydroxy-2-methyl propiophenone and ultraviolet light to form a polyacrylamide network, so that the novel water gel can stably control humidity and effectively remove ammonia in long-term storage, effectively adsorb ammonia and provide molecular-level water molecules, and the required humidity of a cigar is maintained; secondly, the MBA is added into the water gel to form a more stable and porous three-dimensional crosslinking network, which can not only adjust the moisture absorption / relaxation rate of the water gel, realize humidity buffering, but also adsorb ammonia molecules through acid-base neutralization, ion exchange, hydrogen bonding, electrostatic interaction, so that the water gel can maintain the required humidity of the cigar for a long time and reduce the volatilization of ammonia.

The present invention aims to provide a novel B0AT1 inhibitor. [Solution] The present invention relates to a compound represented by formula (I) or a salt thereof that has an inhibitory effect on B0AT1. The present invention also relates to a B0AT1 inhibitor containing the compound, and a pharmaceutical composition containing the compound. One embodiment of the present invention is a pharmaceutical suitable for the prevention and / or treatment of amino acid metabolic disorders such as phenylketonuria, urea cycle disorders, hypertyrosinemia (types 1-3), hypermethioninemia, maple syrup urine disease, homocystinuria, nonketotic hyperglycinemia, propionic acidemia, methylmalonic acidemia, and isovaleric acidemia. In the formula, each symbol is as described in the specification. [C1] JPEG2026137794000308.jpg32170

The invention belongs to the technical field of building material admixtures and relates to a water-reducing hydrated calcium silicate composite early strength agent as well as a preparation method and application thereof. Wherein the polycarboxylic acid water reducer comprises the following components: acrylic acid, methallyl alcohol polyoxyethylene ether, mercaptoacetic acid and 2-hydroxy-4 '-(2-hydroxyethoxy)-2-methyl propiophenone, and the molar ratio of the acrylic acid to the methallyl alcohol polyoxyethylene ether is (5-7): 1; the mercaptoacetic acid accounts for 0.8%-1.6% of the total mole number of the acrylic acid, and the 2-hydroxy-4 '-(2-hydroxyethoxy)-2-methyl propiophenone accounts for 0.84%-0.85% of the total mole number of the methallyl alcohol polyoxyethylene ether. According to the invention, the molecular structure of PCE is accurately designed, and PCE is used as a key regulating agent to actively regulate the nucleation process of C-S-H and the steric hindrance effect among particles, so that the aggregation tendency of the particles is inhibited, the small particle size of the product is ensured, and the long-term dispersion stability is given to the product.

The application belongs to the technical field of organic synthesis, and particularly relates to a preparation method of 4-bromocyclopropylbenzene. The method comprises the following steps: in step 1, bromobenzene, a Lewis acid and 3-chloropropionyl chloride are reacted to obtain 4-bromo-3-chloropropiophenone; in step 2, 4-bromo-3-chloropropiophenone and a reducing agent are reacted to obtain 4-bromochloropropylbenzene; and in step 3, 4-bromochloropropylbenzene is reacted under the action of an alkali catalyst to obtain 4-bromocyclopropylbenzene. The method has the advantages that common reagents are used in each step, the cost of raw materials is low, the synthesis process is short, the yield is high, there is no harsh reaction condition, the method is safe, convenient to operate, friendly to the environment, suitable for large-scale industrial production, and has a good application prospect.

The invention provides a quinoline derivative compound as well as a preparation method and application thereof. The structural formula of the quinoline derivative compound is shown in the specification. The quinoline derivative compound shows remarkable safener activity at a low application dosage, can effectively relieve phytotoxicity of herbicides to crops, shows a good detoxification effect, and remarkably promotes growth recovery of the crops. Compared with existing safeners such as cyclopropanesulfonamide and the like, the quinoline derivative compound disclosed by the invention has higher safety and more excellent detoxification efficiency, particularly has an outstanding relieving effect on crop phytotoxicity caused by p-hydroxyphenylpyruvate dioxidase inhibition herbicides, and can guarantee normal growth and development of crops.

The application belongs to the technical field of adhesive materials, and particularly relates to an anti-plasticizer-outcoming power-on adhesion-reducing adhesive tape and a preparation method thereof. The application provides a preparation method of the anti-plasticizer-outcoming power-on adhesion-reducing adhesive tape, which comprises the following steps: S1, stirring and mixing 30-40 parts of modified polyethylene glycol diacrylate, 30-40 parts of polyurethane acrylate, 4-8 parts of montmorillonite, 2-4 parts of 2-hydroxy-2-methylpropiophenone, 1-3 parts of a plasticizer and 1-3 parts of an antioxidant to obtain a mixture; S2, coating the mixture on a release film by using a doctor blade coater, UV curing for 60-80 s to obtain an adhesive layer, and then attaching a protective film to the adhesive layer to obtain the anti-plasticizer-outcoming power-on adhesion-reducing adhesive tape. The adhesive tape has good power-on adhesion-reducing effect, and can avoid the occurrence of residual glue after power-on.

The invention belongs to the technical field of coatings, and particularly relates to a low-temperature self-repairing anti-frost coating and a preparation method and application thereof.The low-temperature self-repairing anti-frost coating is formed by free radical copolymerization of sulfobetaine methacrylate, hydroxyethyl methacrylate, N, N '-methylene bisacrylamide, boric acid and 2-hydroxy-4'-(2-hydroxyethoxy)-2-methyl propiophenone; wherein the sulfobetaine methacrylate forms a dynamic physical crosslinking point through strong hydration of a zwitterionic structure, and the hydroxyethyl methacrylate enhances the rigidity of the polymer through a hydrogen bond network. Compared with the prior art, the low-temperature frost-resistant coating solves the problems that a conventional low-temperature frost-resistant coating in the prior art does not have a self-repairing function, and the low-temperature frost-resistant coating with the self-repairing function cannot be self-repaired in a low-temperature environment. According to the scheme, a self-repairing function is realized at a lower environment temperature (-20 DEG C), and a long-term frost-resistant solution is provided for equipment which continuously works in a low-temperature environment.

The invention relates to the technical field of coating protection, in particular to a composite protective coating as well as a preparation method and application thereof. The invention provides a composite protective coating. The composite protective coating comprises a photopolymerization precursor mixed solution, graphene oxide and a nitrogen-doped carbon-coated cobalt-doped cadmium sulfide composite nanomaterial, the photopolymerization precursor mixed solution is prepared from triethylene glycol dimethacrylate, 3, 4-epoxycyclohexyl methyl-3, 4-epoxycyclohexyl formate, 2-hydroxy-2-methyl propiophenone and carbonic acid acetate, and the photopolymerization precursor mixed solution is prepared from the following raw materials: triethylene glycol dimethacrylate, 3, 4-epoxycyclohexyl methyl-3, 4-epoxycyclohexyl formate, 2-hydroxy-2-methyl propiophenone and carbonic acid acetate. A protective coating prepared from the composite protective paint has high corrosion resistance and weather resistance.

The invention belongs to the field of biomedical engineering, and discloses a magnetic-thermal double-response hydrogel embolism coil capable of being used for enhancing aneurysm embolism through magnetic guidance and a preparation method and an application method of the magnetic-thermal double-response hydrogel embolism coil. The preparation method comprises the following steps: by taking pentaerythritol tetraacrylate as a cross-linking agent and 2-hydroxy-4 '-(2-hydroxyethoxy)-2-methyl propiophenone as a free radical initiator, adding a thickening and dispersing aid and magnetic nanoparticles, and carrying out free radical polymerization reaction under ultraviolet irradiation, thereby obtaining the magnetic nano-composite material. The magnetic-thermal dual-response hydrogel embolism coil is in a glassy state below room temperature and is used for straightening and stably passing through the micro catheter; and the magnetic-thermal dual-response hydrogel embolism coil recovers to a preset shape when the temperature rises to the body temperature, and is used for realizing an embolism structure of the bag-shaped space. According to the invention, the packing density is obviously improved.

A herbicidal composition and a method for controlling weeds, including one or more uracil compounds of formula (I) and a compound of formula (II), and a herbicide compound of group B and a safener of group C. A weight ratio of the uracil compounds to the herbicide compound group B and the safener group C is 1:0.02 to 1:50, and the herbicide compound of group B is one or more of compounds B-1 to B-12: B-1, acetolactate synthase inhibitors; B-2, acetyl CoA carboxylase inhibitors; B-3, protoporphyrinogen IX oxidase inhibitors; B-4, 4-hydrophenylpyrubic acid dioxygenase inhibitors; B-5, phytoene desaturase inhibitors; B-6, photosystem II inhibitors; B-7, very-long-chain fatty acid synthesis inhibitors; B-8, microtubule formation inhibitors; B-9, auxin-type herbicides; B-10, enolpyruvylshikimate-3-phosphate synthase inhibitors; B-11, glutamine synthase inhibitors; and B-12, other herbicides; or agriculturally acceptable salts or derivatives thereof

The invention relates to preparation of resin, in particular to nanowire array modified acrylate light-cured resin. A commercial photoinitiator 2-hydroxy-2-methyl propiophenone (PI-1173) is mainly introduced into a copper nanowire wrapped by rhenium, zirconium and iron, so that the contact area of the photoinitiator and resin is increased. Re, Zr and Fe on the prepared nanowire array have a synergistic effect, the dispersity of nanoparticles in the epoxy acrylate resin is remarkably improved, and the mechanical property of the acrylic light-cured resin is greatly improved through the combined effect of the two-dimensional layered graphene and the nanowires.

Solid forms of (3aR)-1, 3a, 8-trimethyl-1, 2, 3, 3a, 8, 8a-hexahydropyrrolo (2, 3-b) indol-5-yl phenyl-carbamate tartrate, including crystalline (3aR)-1, 3a, 8-trimethyl-1, 2, 3, 3a, 8, 8a-hexahydropyrrolo (2, 3-b) indol-5-yl phenyl-carbamate tartrate (posiphen D-tartrate Form A), crystalline (3aR)-1, 3a, 8-trimethyl-1, 2, 3, 3a, 8, 8a-hexahydropyrrolo (2, 3-b) indol-5-yl phenyl-carbamate tartrate dihydrate (posiphen D-tartrate Form B), crystalline (3aR)-1, 3a, 8-trimethyl-1, 2, 3, 3a, 8, 8a-hexahydropyrrolo (2, 3-b) indol-5-yl phenyl-carbamate tartrate Form A having the peak of Pattern C (posiphen D-tartrate Form A+Pattern C), and amorphous (3aR)-1, 3a, 8-trimethyl-1, 2, 3, 3a, 8, 8a-hexahydropyrrolo (2, 3-b) indol-5-yl phenyl-carbamate tartrate, are disclosed. Pharmaceutical compositions comprising posiphen D-tartrate Form A, posiphen D-tartrate Form B, posiphen D-tartrate Form A having the peaks of Pattern C, and amorphous posiphen D-tartrate, and methods of treating various conditions by administering these solid forms, are also disclosed.

The invention relates to the technical field of bioengineering, in particular to a ketoreductase mutant as well as a preparation method and application thereof. The ketoreductase cgKR1 derived from candida glabrata is mutated to obtain a ketoreductase mutant, and the ketoreductase mutant is applied to preparation of (R)-3-chloro-1-phenyl-propanol by reducing 3-chloropropiophenone, and compared with wild type ketoreductase cgKR1, the yield of the (R)-3-chloro-1-phenyl-propanol is increased, and the yield of the (R)-3-chloro-1-phenyl-propanol is increased. The ketoreductase mutant provided by the invention has higher enzyme activity and stereoselectivity on the reduction reaction of 3-chloropropiophenone, the isomer purity of a reaction product is greatly improved, and industrial production requirements can be better met.

To provide a pharmaceutical product that has B0AT1 inhibitory activity. [Solution] The present invention is based on formula (I): [C1] TIFF2026066243000332.tif44170 [In the formula, each symbol is as described in the specification.] The present invention relates to a pharmaceutical composition containing a compound represented by or a salt thereof, and a B0AT1 inhibitor. One embodiment of the present invention is a pharmaceutical suitable for the prevention and / or treatment of amino acid metabolic disorders such as phenylketonuria, urea cycle disorders, hypertyrosinemia (types 1-3), hypermethioninemia, maple syrup urine disease, homocystinuria, nonketotic hyperglycinemia, propionic acidemia, methylmalonic acidemia, and isovaleric acidemia.

The application provides a hydrogel-based dressing and a preparation method thereof and a medical product, and relates to the field of materials.The hydrogel-based dressing has a structural formula as shown in the description, wherein m and n are positive integers.The preparation method of the hydrogel-based dressing comprises the following steps: mixing acrylic acid, 3,4-dihydroxybenzoic acid, polyamide epichlorohydrin, N,N'-methylenebisacrylamide, potassium persulfate, 2-hydroxy-4'-(2-hydroxyethoxy)-2-methylpropiophenone and water, and obtaining polyacrylic acid hydrogel through ultraviolet-initiated free radical polymerization; and performing a heating reaction on the polyacrylic acid hydrogel to obtain the hydrogel-based dressing.The medical product comprises the hydrogel-based dressing.The hydrogel-based dressing provided by the application has good antioxidant, antibacterial and ultraviolet resistance capabilities.In practical application to mouse back wounds, the hydrogel-based dressing can effectively promote wound healing and reduce the generation of scars.

The invention discloses a method for preparing (S)-3-chlorophenylpropanol, which comprises the following steps: catalyzing 3-chloropropiophenone by using alcohol dehydrogenase so as to prepare the (S)-3-chlorophenylpropanol, and the reaction system of the method comprises the alcohol dehydrogenase, the 3-chloropropiophenone and reduced coenzyme; the amino acid sequence of the alcohol dehydrogenase is selected from one or more of amino acid sequences as shown in SEQ ID NO: 1, SEQ ID NO: 3, SEQ ID NO: 5 and SEQ ID NO: 7. According to the method provided by the invention, the 3-chloropropiophenone with high concentration (100mg / mL) can be converted into the (S)-3-chlorophenylpropanol, the conversion rate of 100% can be achieved after the reaction is carried out for 6 hours, the ee value can be up to 99.88%, and the method is high in conversion rate, high in stereoselectivity, simple in reaction condition, relatively low in cost and beneficial to industrial production.

The invention discloses antibacterial and antioxidant multifunctional hydrogel compounded with blue copper peptide nanocellulose as well as a preparation method and application of the antibacterial and antioxidant multifunctional hydrogel. The multifunctional hydrogel is prepared by the following steps: continuously introducing nitrogen into a cellulose nanocrystal (CNC) suspension in an acid environment, and fully stirring in an oil bath until the mixture is uniformly mixed; a blue copper peptide (GHK-Cu) raw material containing beta-cyclodextrin inclusion menthol (C-beta-CD at Menthol) is added, and a mixed solution is obtained; the preparation method comprises the following steps: dissolving an acrylamide monomer and an N, N '-methylene bisacrylamide cross-linking agent in deionized water, adding a 2-hydroxy-4'-(2-hydroxyethoxy)-2-methyl propiophenone photoinitiator and the mixed solution in a dark place, and carrying out a polymerization reaction under an ultraviolet lamp. The obtained multifunctional hydrogel is subjected to polymerization reaction under an ultraviolet lamp to form gel, has oxidation resistance, antibacterial property and swelling property, and has great application potential in antibacterial and antioxidant material research in the field of biomedicine.

The application discloses a method for biocatalysis to generate C-glycoside, and belongs to the technical field of bioengineering. A glycosyltransferase is reformed through protein engineering to obtain a mutant with higher yield and regional selectivity. The obtained mutant QDP is used as a biocatalyst, BP-2, 2,4-dihydroxypropiophenone, 4-fluoro-2',4'-dihydroxybenzophenone or 4'-hydroxyphenylheptanone is used as a receptor substrate, and UDP-glucose is used as a donor substrate, so that corresponding C-glucoside modified products are catalytically synthesized, and the method has application value in the synthesis of glycoside compounds.

The present invention relates to a compound having a BOAT1 inhibitory action and represented by the following formula (I):wherein each symbol is as defined in the specification, or a salt thereof. In addition, the present invention relates to a BOAT1 inhibitor containing the aforementioned compound and a pharmaceutical composition containing the aforementioned compound. One embodiment of the present invention is, for example, a medicament preferable for the prophylaxis and / or treatment of amino acid metabolism disorders such as phenylketonuria, urea cycle disorder, hypertyrosinemia (types 1-3), hypermethioninemia, maple syrup urine disease, homocystinuria, nonketotic hyperglycinemia, propionic acidemia, methylmalonic acidemia, isovaleric acidemia and the like.

The invention provides a methcathinone artificial hapten and a synthetic method and application of an artificial antigen. According to the structure of the hapten, a short-chain alkoxycarbonyl chain with carboxyl at the tail end is connected to a methcathinone benzene ring para-position through an ether bond, and a trifluoroacetyl protecting group is introduced to a side chain methylamino group, so that the characteristic structure of methcathinone can be reserved, and coupling side reaction can be avoided. According to the synthetic route, propiophenone is used as a raw material, five-step reactions of CuBr2 bromination, etherification, amination, hydrolysis and trifluoroacetylation are carried out in sequence, the yield of each step is high, the purity is high, and the whole process is green and efficient. The hapten is coupled to bovine serum albumin through an active ester method to prepare an artificial antigen, a high-titer and high-specificity antibody can be obtained after an animal is immunized, and the hapten is suitable for immunodetection of methcathinone in biological samples such as urine and blood and has a good application prospect.