Method of preparing R-(+)-3-chlorophenylpropanol

A kind of technology of chlorophenylpropanol and chloropropiophenone, which is applied in the field of preparation of R-(+)-3-chlorophenylpropanol
CN101012147AActive Publication Date: 2007-08-08XIAMEN FUMAN PHARMA +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
XIAMEN FUMAN PHARMA
Publication Date
2007-08-08

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Abstract

The invention discloses a making method of R-(+)-3-chlophenicol, which is characterized by the following: adopting left-handed bulk of chiral amino acid derivant as catalyst; synthesizing 3-chlophenicol and NaBH4 or KBH4 directly to produce R-(+)-3-chlophenicol; selecting the left-handed bulk from one of left-handed isoleucine derivant, left-handed proline derivant, left-handed tryptophan derivant, left-handed cysteine derivant, left-handed histidine derivant and left-handed methionine derivant.
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Description

technical field

[0001] The invention relates to a preparation method of a useful intermediate 3-chloropropanol which can be used as a drug for treating depression, in particular to a preparation method of its single body R-(+)-3-chloropropanol. Background technique

[0002] Dapoxetine, chemical name S-(+)-N,N-dimethyl-α-[2-(naphthyloxy)ethyl]benzylamine hydrochloride (N,N-dimethyl- α-[2-(naphthalenyloxy)ethyl]benyenemethanamine hydrochloride), is a selective serotonin reuptake inhibitor, which can be used for the treatment of depression, alcoholism, weight loss, amnesia and other diseases, for forgetfulness, irritability, depression, Aloof and effective, it is also the world's first oral drug for the treatment of premature ejaculation in men. The drug is a selective serotonin uptake inhibitor and has no direct effect on neuronal receptors. Since this class of drugs does not effectively inhibit other monoamines, less side effects are expected after administration.

[0003] ...

Claims

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