A kind of stem cell ointment for treating skin damage and preparation method thereof

Abstract

The invention provides a preparation method of stem cell ointment and the ointment prepared by the method. In the present invention, mesenchymal stem cells with immune regulation and tissue regeneration functions are prepared into agglomerates of uniform size under 3D suspension culture conditions, and mixed in a non-biotoxic active energy matrix to prepare an ointment. Stem cells can survive in this ointment at room temperature for up to a week, maintaining biological activity. The stem cell ointment provided by the invention can be directly applied to the damaged skin, and the stem cells therein will migrate into the wound to suppress inflammation and promote tissue regeneration, accelerate wound healing and significantly improve the healing condition, and reduce scar formation. After the repair process is completed, the stem cells will be cleared by the autoimmune system without residue, safe, stable and efficient.

Description

technical field [0001] The invention relates to the field of cell biology, in particular to mixing stem cells with biologically active functions with a non-biotoxic matrix to make an ointment and a preparation method for the ointment. Background technique [0002] Acute and chronic wounds, such as various ulcers, ischemia-hypoxic wounds and burn residual wounds, endanger human health and affect the quality of life, and have become a huge problem in modern society. Due to the sharp increase in obesity, diabetes, and the aging population, the incidence of various skin injuries, especially chronic wounds, continues to rise. The treatment of these wounds consumes significant socioeconomic resources. The current means of wound treatment mainly include antibiotic intervention, surgery and negative pressure therapy. Although these treatments have made great progress, the healing rate of chronic wounds is still less than 50%. In the past two decades, stem cell research has made tr...

AI Technical Summary

Problems solved by technology

This method can partially improve wound healing, but because the low survival rate of single cells greatly affects the curative effect, how to improve the survival rate of cells after transplantation is the key to increasing the curative effect

There is an inflammatory environment in the wound, and the damaged blood vessels cause ischemia and hypoxia. It is difficult for conventionally cultured cells to adapt to such an environment. After transplantation, the high mortality rate often affects the curative effect

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