A kind of absorbable bone wax composition

A technology of composition and bone wax, which can be used in drug delivery, tissue regeneration, surgical adhesives, etc., can solve the problems of poor flushing resistance, poor sealing strength, and poor mechanical properties, and achieve easy shaping, high sealing strength, The effect of good spreadability and shaping

Active Publication Date: 2021-05-11
上海鹏冠生物医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the mixture of beeswax and petroleum jelly is not degradable. At present, degradable bone wax has gradually appeared on the market, but the existing degradable bone wax has poor mechanical properties, specifically manifested as poor washout resistance, difficulty in shaping, and poor sealing strength. The problem

Method used

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  • A kind of absorbable bone wax composition
  • A kind of absorbable bone wax composition

Examples

Experimental program
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Effect test

specific Embodiment 1

[0022] This specific example discloses another absorbable bone wax composition, the base of which includes fatty acid glycerides and degradable polymers, wherein the weight content of fatty acid glycerides is 40%, and the weight content of degradable polymers is 60% The fatty acid glyceride is glyceryl stearate, the monomer of the degradable polymer is lactide, the degradable polymer is polylactic acid, and the molecular weight of the polylactic acid is 500.

[0023] The applicant compared the performance of the absorbable bone wax composition in this example with the existing bone wax products, and the specific results are shown in Table 1.

specific Embodiment 2

[0025] This specific example discloses another absorbable bone wax composition, the base of which includes fatty acid glycerides and degradable polymers, wherein the weight content of fatty acid glycerides is 85%, and the weight content of degradable polymers is 15% , the fatty acid glyceride is linoleic acid glyceride, the monomer of the degradable polymer is ethylene oxide, the degradable polymer is polyethylene glycol, and the molecular weight of the polyethylene glycol is 5000.

[0026] The applicant compared the performance of the absorbable bone wax composition in this example with the existing bone wax products, and the specific results are shown in Table 1.

specific Embodiment 3

[0028] This specific example discloses another absorbable bone wax composition, the base of which includes fatty acid glycerides and degradable polymers, wherein the weight content of fatty acid glycerides is 60%, and the weight content of the degradable polymers is 40%, the fatty acid glyceride is a mixture of glyceryl stearate and glyceryl linoleate, and the monomer of the degradable polymer is ethylene oxide with a mass fraction of 60% and propylene oxide with a mass fraction of 40%, The molecular weight of the degradable polymer is 2500.

[0029] The applicant compared the performance of the absorbable bone wax composition in this example with the existing bone wax products, and the specific results are shown in Table 1.

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Abstract

The invention discloses an absorbable bone wax composition, the base of which comprises fatty acid glyceride and a degradable polymer, the weight content of the fatty acid glyceride is 40% to 85%, and the weight content of the degradable polymer is 15% to 60%. The fatty acid glyceride is selected from glyceryl stearate, glyceryl palmitate, glyceryl linoleate and glyceryl laurate. The degradable polymer monomer is selected from lactide, glycolide, caprolactone, ethylene oxide, propylene oxide. The molecular weight of the degradable polymer is 500-5000. The absorbable bone wax composition of the present invention can be degraded and absorbed, and has good mechanical properties, good biocompatibility and safety, and can be applied clinically to hemostasis of bone wounds and filling of bone defects. The ingredients make bone wax have a good hemostatic effect.

Description

technical field [0001] The invention relates to the technical field of hemostatic materials, in particular to an absorbable bone wax composition. Background technique [0002] During orthopedic surgery, bone bleeding may occur. In the control of bone bleeding or hemostasis, people have studied and developed bone wax as a mechanical barrier applied to the bone, which can effectively stop bleeding. Existing bone wax is generally a mixture of beeswax and vaseline, the product is white or light yellow, has good softening properties, can be molded after being softened by hand rubbing, and can solve the problem of inhibiting bone hemorrhage. However, the mixture of beeswax and petroleum jelly is not degradable. At present, degradable bone wax has gradually appeared on the market, but the existing degradable bone wax has poor mechanical properties, specifically manifested as poor washout resistance, difficulty in shaping, and poor sealing strength. The problem. [0003] Therefore...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L24/04A61L24/02A61L24/00A61L27/18A61L27/12A61L27/54A61L27/58A61L27/50
CPCA61L24/001A61L24/0015A61L24/0042A61L24/02A61L24/046A61L27/12A61L27/18A61L27/50A61L27/54A61L27/58A61L2300/412A61L2400/04A61L2430/02C08L67/04C08L71/02
Inventor 朱宏彬刘超严祝奇洪根东
Owner 上海鹏冠生物医药科技有限公司
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