Mesoporous silicon dioxide and cellulose blended membrane protected by buffer solution, preparation method and application thereof

A mesoporous silica and buffer solution technology, applied in chemical instruments and methods, bandages, water/sludge/sewage treatment, etc., can solve problems such as structural damage, achieve high adsorption performance, prevent wound infection, and react products Gentle and non-polluting effect

Active Publication Date: 2018-12-14
WUHAN INSTITUTE OF TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, mesoporous silica is an acidic oxide, and its structure will be destroyed soon in a strong alkaline solution.

Method used

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  • Mesoporous silicon dioxide and cellulose blended membrane protected by buffer solution, preparation method and application thereof
  • Mesoporous silicon dioxide and cellulose blended membrane protected by buffer solution, preparation method and application thereof
  • Mesoporous silicon dioxide and cellulose blended membrane protected by buffer solution, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] A method for preparing a mesoporous silica and cellulose blend membrane protected by a buffer solution, the specific steps are as follows:

[0028] 1) Configure 0.5mol / L phosphate buffer solution (pH=6.0);

[0029] 2) Disperse the SBA-15 particles in the buffer solution prepared in step 1), soak for 48 hours to obtain a SBA-15 mesoporous silica / phosphate buffer solution dispersion with a mass fraction of 15%, and refrigerate to -5°C until use;

[0030] 3) Prepare cellulose solvent, pre-cool to -12°C, then add cellulose, stir to dissolve, defoam and remove impurities, and finally obtain a cellulose solution with a mass fraction of 4%;

[0031] 4) Add the pre-cooled mesoporous silica / buffer solution dispersion prepared in step 2) into the cellulose solution pre-cooled to -10°C, and stir mechanically for 2 minutes to obtain a SBA-15 particle mass fraction of 2%. Casting solution;

[0032] 5) Pour the casting liquid prepared in step 4) into the film-making template, use ...

Embodiment 2

[0036] A method for preparing a mesoporous silica and cellulose blend membrane protected by a buffer solution, the specific steps are as follows:

[0037] 1) Configure 0.2mol / L phosphate buffer solution (pH=6.0);

[0038]2) Disperse the SBA-15 particles in the buffer solution prepared in step 1), soak for 24 hours to obtain a SBA-15 mesoporous silica / phosphate buffer solution dispersion with a mass fraction of 10%, and refrigerate to -3°C until use;

[0039] 3) Prepare cellulose solvent, pre-cool to -12°C, then add cellulose, stir to dissolve, defoam and remove impurities, and finally obtain a cellulose solution with a mass fraction of 3.5%;

[0040] 4) Add the pre-cooled mesoporous silica / buffer solution dispersion prepared in step 2) into the cellulose solution pre-cooled to -10°C, and stir mechanically for 1 minute to obtain a SBA-15 particle mass fraction of 1%. Casting solution;

[0041] 5) Pour the casting liquid prepared in step 4) into the film-making template, use ...

Embodiment 3

[0045] A method for preparing a mesoporous silica and cellulose blend membrane protected by a buffer solution, the specific steps are as follows:

[0046] 1) Prepare 0.1mol / L citric acid-sodium citrate buffer solution (pH=6.4);

[0047] 2) Disperse the MCM-41 particles in the buffer solution prepared in step 1), soak for 72 hours to obtain the MCM-41 mesoporous silica / citric acid-sodium citrate buffer solution dispersion with a mass fraction of 5%, and refrigerate until -3°C for use;

[0048] 3) Prepare cellulose solvent, pre-cool to -12°C, then add cellulose, stir to dissolve, defoam and remove impurities, and finally obtain a cellulose solution with a mass fraction of 4%;

[0049] 4) Add the pre-cooled mesoporous silica / buffer solution dispersion prepared in step 2) into the cellulose solution pre-cooled to -10°C, and stir mechanically for 3 minutes to obtain MCM-41 particles with a mass fraction of 0.5%. Casting solution;

[0050] 5) Pour the casting solution prepared in...

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Abstract

The present invention discloses a mesoporous silicon dioxide and cellulose blended membrane protected by a buffer solution, a preparation method and an application thereof. The blended membrane is obtained by shaping a membrane casting solution; and the membrane casting solution comprises the buffer solution, mesoporous silicon dioxide and a cellulose solvent. The preparation method of the blend membrane comprises the following steps: (1) the buffer solution is prepared and a pH range is 2.2-10.1; (2) the mesoporous silicon dioxide is dispersed in the buffer solution prepared in the step (1) to obtain a disperse solution; the disperse solution is pre-cooled; and the pre-cooled disperse solution is blended with a pre-cooled cellulose solution to obtain the membrane casting solution; and (3)rolling processes are used; and curing is conducted in a curing solution to obtain the blended membrane. A dressing uses the blended membrane as a carrier to adsorb a drug solution. In the blend membrane, the buffer solution and low-temperature both have protective effects on the inner and outer surfaces of the mesoporous silicon dioxide; and because pore channels are filled with the buffer solution and are not destroyed by strong alkali, the mesoporous silicon dioxide in the blend membrane still has excellent adsorption properties and sustained release properties.

Description

technical field [0001] The invention relates to the technical field of functional polymer materials, in particular to a mesoporous silicon dioxide and cellulose blend membrane protected by a buffer solution, a preparation method and application thereof. Background technique [0002] As a covering for wounds, medical dressings can replace damaged skin to act as a temporary barrier during wound healing, avoid or control wound infection, and provide an environment conducive to wound healing. Along with the increase of diabetic patient and chronic ulcerative wound, the market value of medical dressing also becomes more and more important. In the second half of the 19th century, the surgeon Gamgee invented the absorbent and antibacterial Gamgee dressing, a cotton pad. Since Dr. George Winter, a British scientist, discovered that a humid environment is beneficial to wound healing in 1962, and put forward the "moist wound healing theory", people have made breakthroughs in understa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L1/02C08K9/02C08K7/26C08J5/18C02F1/28A61L15/28A61L15/18A61L15/44A61L15/46A61L15/42C02F101/20
CPCA61L15/18A61L15/28A61L15/425A61L15/44A61L15/46A61L2300/406A61L2300/41A61L2300/414C02F1/288C02F2101/20C08J5/18C08J2301/02C08K7/26C08K9/02C08L1/02
Inventor 喻发全沈陟薛亚楠王建芝蔡宁谌伟明
Owner WUHAN INSTITUTE OF TECHNOLOGY
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