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Graphene fever cooling patch for children and preparation method thereof

A technology of graphene and antipyretic plasters, which is applied in the direction of antipyretics, pharmaceutical formulas, and medical preparations with non-active ingredients, etc. It can solve problems such as complex processes, expensive materials, and low safety, and achieves simple production methods and high-quality medicines. Long-lasting, low-cost results

Inactive Publication Date: 2018-12-18
GUANGXI UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Some antipyretic stickers for infants and young children that have appeared recently also have disadvantages such as low safety, complicated process, and expensive materials.

Method used

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  • Graphene fever cooling patch for children and preparation method thereof
  • Graphene fever cooling patch for children and preparation method thereof
  • Graphene fever cooling patch for children and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] The preparation of embodiment 1 graphene children's antipyretic plaster

[0023] Follow the steps below:

[0024] (1) Extraction of medicinal materials: by weight, take 20 parts of Bing, 20 parts of mint, 15 parts of Jade leaf golden flower, 10 parts of ginger, and 4 parts of perilla leaf, crush them, soak in 70% ethanol solution for 3 hours, and soak for 1-3 times , combine the leachate, concentrate under reduced pressure, clarify, decolorize, apply AB-8 macroporous adsorption resin, elute with 50% ethanol, concentrate the eluent under reduced pressure, and dry to obtain the Chinese medicine extract with a yield of 65%;

[0025] (2) Preparation of graphene-based drug-loaded gel: disperse 200mg of graphene powder in 1L of Chinese medicine extract aqueous solution, the Chinese medicine extract aqueous solution is prepared according to the weight ratio of Chinese medicine extract to water 1:100, ultrasonic 1h to obtain Graphene dispersion, stir vigorously, add 1mol / L gel...

Embodiment 2

[0027] The preparation of embodiment 2 graphene children's antipyretic patch

[0028] Follow the steps below:

[0029] (1) Extraction of medicinal materials: by weight, take 18 parts of Bing, 17 parts of peppermint, 12 parts of Jade leaf golden flower, 7 parts of ginger, and 2 parts of perilla leaf, crush them, soak in 60% ethanol solution for 3 hours, and soak for 1-3 times , combine the leachate, concentrate under reduced pressure, clarify, decolorize, apply NKA-9 macroporous adsorption resin, elute with 40% ethanol, concentrate the eluent under reduced pressure, dry, and obtain the Chinese medicine extract with a yield of 89%;

[0030] (2) Preparation of graphene-based drug-loaded gel: disperse 200mg of graphene powder in 1L of Chinese medicine extract aqueous solution, the Chinese medicine extract aqueous solution is prepared according to the weight ratio of Chinese medicine extract and water 1:50, ultrasonic 1h to obtain Graphene dispersion, stir vigorously, add 1mol / L g...

Embodiment 3

[0032] The preparation of embodiment 3 graphene children's antipyretic patch

[0033] Follow the steps below:

[0034] (1) Extraction of medicinal materials: by weight, take 15 parts of Bing, 15 parts of Mint, 10 parts of Jade Leaf Golden Flower, 5 parts of Ginger, and 2 parts of Su Ye, crush them, soak in 40% ethanol solution for 3 hours, soak 1-3 times , combined the leachate, concentrated under reduced pressure, clarified, decolorized, applied D4020 macroporous adsorption resin, eluted with 30% ethanol, concentrated the eluate under reduced pressure, dried, and obtained the Chinese medicine extract with a yield of 72%;

[0035] (2) Preparation of graphene-based drug-loaded gel: Disperse 200mg of graphene powder in 1L of Chinese medicine extract aqueous solution. Graphene dispersion, stir vigorously, add 1mol / L gelatin solution dropwise, continue to stir fully for 1h, mix completely and let stand for 24h, discharge air bubbles to obtain graphene-gelatin drug-loaded hydrogel...

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Abstract

The invention provides a graphene fever cooling patch for children and a preparation method thereof. The preparation method comprises the following steps: (1) crushing cortex llicis rotundae, mint, mussaenda pubescens stem and root, ginger and perilla leaves, soaking with an ethanol solution for 1 to 3 times, merging leachate, decompression concentrating, clarifyingsedimenting, destaining, loadingAB-8 macroporous absorption resin, eluting with ethanol, decompression concentrating an elution solution, drying,and to obtaining Chinese herbal extract; (2) dispersing graphene powder in a Chinese herbal extract aqueous solution, ultrasonically dispersing, stirring, dropwise adding a gelatin solution, stirring, standing,and to obtaining graphene-gelatin drug-loading hydrogel; and (3) uniformly stirring a product of step (2), pouring into a mold, solidifying and shaping,and to obtaining the graphene fever cooling patch for children. The Chinese herbal extract is combined with the graphene material to prepare the hydrogel dose form which is applied to a paste, so that the drug effect can be maximally played, the absorption by a patient can be facilitated, and a good fever cooling treatmenteffect can be achieved.

Description

technical field [0001] The invention relates to the technical field of antipyretic plasters for external use, in particular to a graphene antipyretic plaster for children. Background technique [0002] Fever refers to a body temperature exceeding the upper limit of the normal range, which is a very common symptom in children. Normal children's axillary surface temperature is 36°C-37°C (the body temperature measured by the anal surface is about 0.3°C higher than the oral surface, and the body temperature measured by the oral surface is about 0.4°C higher than the surface), and if the axillary surface exceeds 37.4°C, it can be considered as fever . In most cases, fever is a protective response of the body against invading pathogens, a process in which the body is mobilizing the immune system to fight infection. Fever is the first symptom of some common diseases in infants and young children. Respiratory tract, digestive tract infections, and some infectious diseases will all...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9068A61K9/06A61K47/04A61P29/00
CPCA61K9/0014A61K9/06A61K36/185A61K36/534A61K36/535A61K36/74A61K36/9068A61K47/02A61P29/00A61K2300/00
Inventor 赵立春唐农宋策钟余特王雪于培良李俊秀
Owner GUANGXI UNIV OF CHINESE MEDICINE
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