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Method for preparing hollow microneedle array

A microneedle array and hollow technology, which is applied in the field of micromachining, can solve the problems of complex preparation process, high cost and poor structure controllability of the hollow microneedle array, and achieves the effects of high cost, simple operation and uniform material.

Active Publication Date: 2018-12-25
HUAZHONG UNIV OF SCI & TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] In view of the above defects or improvement needs of the prior art, the object of the present invention is to provide a method for preparing hollow microneedle arrays in batches, wherein by improving the setting of the overall process flow of the preparation method, compared with the prior art, it can effectively Solve the current problems such as complex preparation process, high cost and poor structure controllability of hollow microneedle arrays

Method used

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  • Method for preparing hollow microneedle array
  • Method for preparing hollow microneedle array
  • Method for preparing hollow microneedle array

Examples

Experimental program
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Effect test

Embodiment 1～7

[0031] In summary, Embodiments 1 to 7 all include the following steps:

[0032] 1. Preparation of the PMMA microneedle array negative template: adjust the laser engraving machine processing parameters (as shown in Table 1), so that the laser etches microneedle holes of different sizes on the PMMA substrate;

[0033]2. Preparation of PDMS microneedle array positive template: Mix PDMS (Sylgard 184) and curing agent evenly at a mass ratio of 10:1, let stand for a period of time to remove the air bubbles in the mixture, and add the above-mentioned PMMA microneedle array positive template. Vacuum the surface of the template for several minutes to allow PDMS to enter and fill the holes to obtain a positive PDMS microneedle array template with the same size as the PMMA microneedle array negative template;

[0034] 3. Coating a layer of silver seed layer on the surface of PDMS microneedle array positive template by silver mirror reaction;

[0035] 4. Electroplating a metal nickel (Ni...

Embodiment 8～13

[0042] In summary, Embodiments 8 to 13 all include the following steps:

[0043] 1. Preparation of PDMS substrate: Mix PDMS (Sylgard 184) and curing agent evenly at a mass ratio of 10:1, let it stand for a while to remove the air bubbles in the mixture, and then heat it at 100°C for 1 hour to make it completely solidified. Obtain the PDMS substrate;

[0044] 2. Preparation of the negative template of the PDMS microneedle array: adjust the processing parameters of the laser engraving machine so that the laser power is 100W, the laser scanning speed is 10 mm / s, and the number of times is 1, so that the laser can etch on the PDMS substrate with a length of about 2000μm microneedle array negative template;

[0045] 3. Preparation of polymethyl methacrylate (PMMA) microneedle array positive template: place the PMMA plate on the surface of the above-mentioned PDMS microneedle array negative template engraved with holes, heat and vacuum, so that PMMA enters and fills the holes, Obt...

Embodiment 14

[0054] This embodiment comprises the following steps:

[0055] 1. Preparation of PDMS substrate: Mix PDMS (Sylgard 184) and curing agent evenly at a mass ratio of 10:1, let it stand for a while to remove the air bubbles in the mixture, and then heat it at 100°C for 1 hour to make it completely solidified. Obtain the PDMS substrate;

[0056] 2. Preparation of the negative template of the PDMS microneedle array: adjust the processing parameters of the laser engraving machine so that the laser power is 100W, the laser scanning speed is 10 mm / s, and the number of times is 1, so that the laser can etch on the PDMS substrate with a length of about 2000μm microneedle array negative template;

[0057] 3. Preparation of the positive template of the polypropylene microneedle array: place the polypropylene plate on the surface of the negative template of the PDMS microneedle array engraved with holes above, heat and vacuumize, so that the polypropylene enters and fills the holes, and th...

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Abstract

The invention discloses a method for preparing a hollow microneedle array in bulk. The method for preparing the hollow microneedle array particularly comprises the steps that by means of a microneedlearray negative template with holes, a polymer microneedle array positive template is prepared, and then a metal seed layer is plated on the polymer microneedle positive template; then, a metal structure layer is electroplated on the microneedle array positive template with the surface attached with the metal seed layer, and a microneedle array needle wall is formed; organic solvent is used for removing the polymer microneedle array positive template, a metal microneedle array is obtained, the top of the microneedle array is subjected to polishing or laser cutting, and the hollow metal microneedle array can be obtained. Accordingly, by improving the whole technological process of the preparation method, compared with the prior art, the problems that at present, the hollow microneedle arraypreparation technology is complex, the cost is high, and the structural controllability is poor can be effectively solved.

Description

technical field [0001] The invention belongs to the technical field of micromachining, and more specifically relates to a method for preparing a hollow microneedle array, in particular, the hollow microneedle array can be prepared in batches based on laser engraving and electroplating technologies. Background technique [0002] With the development of microelectromechanical processing technology, microneedles are widely used in the medical field and are expected to become the next generation of transdermal drug delivery medical devices. Among them, hollow microneedles have outstanding advantages in microfluidic biomedical applications, which can realize the functions of drug delivery and blood collection at the same time, and can greatly reduce the pain during drug delivery or sampling. In addition, hollow microneedles can also be integrated with microfluidic chips to realize the integration of sampling, diagnosis and drug delivery. [0003] However, the current methods for...

Claims

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Application Information

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IPC IPC(8): A61M37/00
CPCA61M37/0015A61M2037/0053
Inventor 朱锦涛王华李钰策张连斌柳佩陶娟朱今巾杜虹瑶
Owner HUAZHONG UNIV OF SCI & TECH
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