Glucose-response-driven hydrogel multistage motor and production method thereof

A glucose-responsive, hydrogel technology, applied in the field of glucose-responsive-driven hydrogel multistage motors and its preparation, can solve the problems of living cell poisoning and limit the application of hydrogel motors, and achieve reduced surface tension and excellent drive The effect of high performance and driving average speed

Active Publication Date: 2018-12-25
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The hydrogel two-stage motor prepared by us using Ag nanoparticles has very excellent driving performance (J. Mater. Chem. A, 2017, 5, 18442–18447), but this catalytic hydrogel two-stage motor only in H 2 o 2 Ambient drive, H 2 o 2 Can be toxic to living cells, which limits the application of hydrogel motors in biological fields

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] (1) Take 5 mg of Lithium Diatomaceous Earth (Lithium Diatomaceous Earth) and dry it in an oven in advance. After drying, disperse it in 1 mL of ultrapure water and stir. Ultrasound for 30 min in an ice bath to form a uniform Lithium Diatomaceous Earth dispersion.

[0037] (2) Take 56.5 mg of N-isopropylacrylamide, 19.1 mg of 3-acrylamidophenylboronic acid, 9.3 mg of N,N-methylenebisacrylamide and 17.3 mg of sodium lauryl sulfate and add them to step (1 ) In the obtained lithium algae earth dispersion, stir and disperse evenly, add 3.4 mg 2,2'-azo(2-methylpropyl amidine) dihydrochloride and 10 μL N,N, under light-proof conditions N',N'-Tetramethylethylenediamine, ultrasonic in an ice bath to make the mixture uniformly mixed, and pass nitrogen for 10 min to remove the oxygen dissolved in the mixture.

[0038] (3) First, add a small removable silicone mold block to the large mold hole, and quickly inject the mixed solution into the mold. The solution in each hole is 25 μL. Afte...

Embodiment 2

[0045] (1) Take 10 mg of Lithium Diatomaceous Earth (Lithium Diatomaceous Earth) and dry it in an oven in advance. After drying, disperse it in 1 mL of ultrapure water and stir. Ultrasound for 30 min in an ice bath to form a uniform Lithium Diatomaceous Earth dispersion.

[0046] (2) Take 60 mg of N-isopropylacrylamide, 15 mg of methacrylamide phenylboronic acid, 5.0 mg of N,N-methylene bisacrylamide and 20.0 mg of sodium lauryl sulfate and add to step (1) In the obtained lithium algae earth dispersion, stir and disperse evenly, add 2.5 mg of 2,2'-azo(2-methylpropyl amidine) dihydrochloride and 5 μL of N,N,N under light-proof conditions ',N'-Tetramethylethylenediamine, ultrasonically in an ice bath to make the mixture uniformly mixed, and pass nitrogen for 10 min to remove the oxygen dissolved in the mixture.

[0047] (3) First add a small removable silicone mold block to the large mold hole, and quickly inject the mixed solution into the mold. The solution in each hole is 15 μL. A...

Embodiment 3

[0054] (1) Take 5 mg of Lithium Alonite (Lithium Alonite) and dry it in an oven in advance. After drying, disperse it in 1 mL of ultrapure water and stir. Ultrasound for 30 min in an ice bath to form a uniform Lithium Alonite dispersion.

[0055] (2) Take 56.5 mg of acrylamide, 19.1 mg of methacrylamide phenylboronic acid, 9.3 mg of N,N-methylenebisacrylamide and 17.3 mg of polyethylene glycol and add them to the lithium algae earth dispersion obtained in step (1) Stir and disperse evenly, add 4.5 mg of 2,2'-azo (2-methylpropyl amidine) dihydrochloride and 20 μL of N,N,N',N'-tetramethyl under dark conditions Ethylenediamine, ultrasonic in an ice bath to make the mixture evenly mixed, and nitrogen gas for 10 min to remove the oxygen dissolved in the mixture.

[0056] (3) First add a small removable silicone mold block into the large mold hole, and quickly inject the mixed solution into the mold. The solution in each hole is 10 μL. After all the mold holes are injected, the high-inte...

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Abstract

The invention discloses a glucose-response-driven hydrogel multistage motor and a production method thereof. The method includes: using silica gel to produce a mould; adding movable silica gel small mould blocks into mould holes during drive layer production; after the drive layer production, taking out the movable silica gel small mould blocks, dropwise adding gelatin/agar mixed solutions of different proportion into interval areas, and gelatinizing the solutions to form the glucose-response intelligent hydrogel multistage motor capable of achieving fast drive. The produced hydrogel multistage motor can achieve self-driving in a drive solution and has excellent drive performance, the drive average speed reaches up to 16.2+/-1.3mm/s, a decomposition layer can be dissolved step by step through temperature control or infrared irradiation, and the small motor releases step by step and freely propels. Compared with a traditional motor, the hydrogel multistage motor is faster in driving, more intelligent and higher in controllability.

Description

Technical field [0001] The invention relates to the field of functional polymer materials, in particular to a hydrogel multi-stage motor driven by glucose response and a preparation method thereof. Background technique [0002] In biological systems, many biomolecular machines can be driven autonomously with external fuel. Inspired by biomolecular machines, researchers have developed various artificial motors that can be driven autonomously in a liquid environment. In recent years, the development of intelligent machines has attracted more and more attention. Motors made of metals and inorganic materials are still lacking in intelligent applications, and the controllability of motors is weak. Due to its own excellent characteristics: good biocompatibility, strong hydrophilicity, softness and toughness, hydrogels can maintain a certain shape, and can respond to external environmental stimuli. Therefore, in the intelligent The development of the field has received more and more at...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L89/00C08L5/12C08L33/24C08K3/04C08K7/26C08J3/075C08F220/54C08F230/06C08F222/38C08F2/44
CPCC08F2/44C08F220/54C08J3/075C08J2333/24C08J2389/00C08J2405/12C08J2433/24C08J2489/00C08K7/26C08K3/042C08F230/06C08F222/385
Inventor 王朝阳梁玉玲雷志文陈云华
Owner SOUTH CHINA UNIV OF TECH
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