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A glucose response-driven hydrogel multistage motor and its preparation method

A glucose-responsive, hydrogel technology is applied in the field of glucose-responsive-driven hydrogel multi-stage motors and their preparation, which can solve the problems of limiting the application of hydrogel motors and intoxication of living cells, achieve excellent driving performance, reduce surface Tension, controllable effect

Active Publication Date: 2021-02-12
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The hydrogel two-stage motor prepared by us using Ag nanoparticles has excellent driving performance (J.Mater.Chem.A, 2017, 5, 18442–18447), but this catalytic hydrogel two-stage motor only in H 2 o 2 Ambient drive, H 2 o 2 Can be toxic to living cells, which limits the application of hydrogel motors in biological fields

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] (1) Take 5mg of lithium diatomaceous earth (lithium diatomaceous earth) and dry it in an oven in advance. After drying, disperse it in 1mL of ultrapure water, stir, and ultrasonicate in an ice bath for 30min to form a uniform lithium diatomaceous earth dispersion.

[0037] (2) Take 56.5mg of N-isopropylacrylamide, 19.1mg of 3-acrylamidophenylboronic acid, 9.3mg of N,N-methylenebisacrylamide and 17.3mg of sodium lauryl sulfate into step (1 ) into the lithium dispersion liquid obtained, stir and disperse evenly, add 3.4mg 2,2'-azo(2-methylpropylamidine) dihydrochloride and 10μL N,N,N ',N'-Tetramethylethylenediamine, ultrasonically mix the mixture in an ice bath, and pass nitrogen gas for 10 minutes to remove the oxygen dissolved in the mixture.

[0038] (3) First, add a small removable silica gel mold block into the large mold hole, and quickly inject the mixed solution into the mold. (The power of the ultraviolet lamp is 1kW) and polymerize for 3 minutes. After the poly...

Embodiment 2

[0045] (1) Take 10 mg of lithium diatomaceous earth (lithium diatomaceous earth) and dry it in an oven in advance. After drying, disperse it in 1 mL of ultrapure water and stir it. Ultrasound in an ice bath for 30 minutes to form a uniform lithium diatomaceous earth dispersion.

[0046] (2) Take 60mg of N-isopropylacrylamide, 15mg of methacrylamide phenylboronic acid, 5.0mg of N,N-methylenebisacrylamide and 20.0mg of sodium lauryl sulfate to the obtained product in step (1). Add 2.5 mg of 2,2'-azo(2-methylpropylamidine) dihydrochloride and 5 μL of N,N,N',N '-Tetramethylethylenediamine, ultrasonically mix the mixture in an ice bath, and pass nitrogen gas for 10 minutes to remove the oxygen dissolved in the mixture.

[0047] (3) First, add a movable small mold block of silica gel to the large mold hole, quickly inject the mixed solution into the mold, the solution in each hole is 15μL, after injecting all the mold holes, put it under the high-intensity ultraviolet lamp (The pow...

Embodiment 3

[0054] (1) Take 5mg of lithium diatomaceous earth (lithium diatomaceous earth) and dry it in an oven in advance. After drying, disperse it in 1mL of ultrapure water, stir, and ultrasonicate in an ice bath for 30min to form a uniform lithium diatomaceous earth dispersion.

[0055] (2) Add 56.5mg of acrylamide, 19.1mg of methacrylamide phenylboronic acid, 9.3mg of N,N-methylenebisacrylamide and 17.3mg of polyethylene glycol to the lithium diatomaceous earth dispersion obtained in step (1) , stir and disperse evenly, add 4.5mg 2,2'-azo(2-methylpropylamidine) dihydrochloride and 20μL N,N,N',N'-tetramethylethane diamine, ultrasonically in an ice bath to mix the mixed solution evenly, and pass nitrogen gas for 10 minutes to remove the oxygen dissolved in the mixed solution.

[0056] (3) First add a movable small mold block of silica gel into the large mold hole, quickly inject the mixed solution into the mold, the solution in each hole is 10μL, after injecting all the mold holes, pu...

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Abstract

The invention discloses a hydrogel multistage motor driven by glucose response and a preparation method thereof. The preparation of the hydrogel multistage motor is divided into two parts. The mold is made of silica gel. When the driving layer is prepared, a small movable silica gel mold block is added in the middle of the mold hole. After the driving layer is prepared, the movable small silica gel mold block is taken out. Then, different ratios of gelatin / agar mixed solutions were added dropwise inside the interval area, and finally gelled, forming a glucose-responsive, fast-driving, and intelligent hydrogel multistage motor. After the hydrogel multistage motor is formed, the motor is self-driven in the driving solution, which has excellent driving performance, and the average driving speed can reach up to 16.2±1.3 mm / s. The decomposition layer can be gradually dissolved by temperature control or infrared irradiation. , the small motor releases step by step and advances freely. Compared with traditional motors, this hydrogel multistage motor is faster, more intelligent, and more controllable.

Description

technical field [0001] The invention relates to the field of functional polymer materials, in particular to a glucose-responsive-driven hydrogel multistage motor and a preparation method thereof. Background technique [0002] In biological systems, many biomolecular machines can drive autonomously with external fuels. Inspired by biomolecular machines, researchers have developed various artificial motors that can drive autonomously in liquid environments. In recent years, the development of intelligent machines has received more and more attention. Motors made of metal and inorganic materials are still somewhat lacking in intelligent applications, and the controllability of motors is weak. Due to its own excellent characteristics: good biocompatibility, strong hydrophilicity, softness and toughness, can maintain a certain shape, and respond to external environmental stimuli, hydrogels are widely used in intelligent Developments in the field are getting more and more attenti...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08L89/00C08L5/12C08L33/24C08K3/04C08K7/26C08J3/075C08F220/54C08F230/06C08F222/38C08F2/44
CPCC08F2/44C08F220/54C08J3/075C08J2333/24C08J2389/00C08J2405/12C08J2433/24C08J2489/00C08K7/26C08K3/042C08F230/06C08F222/385
Inventor 王朝阳梁玉玲雷志文陈云华
Owner SOUTH CHINA UNIV OF TECH