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Lyotropic liquid crystal injection for soft tissue regeneration and vascularization promotion and preparation method thereof

A technology of lyotropic liquid crystals and injections, which is applied in the direction of cardiovascular system diseases, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., which can solve the problem of difficult release, limited application, and rarely used macromolecular protein drugs and other issues, to achieve the effect of enhancing the efficacy, prolonging the action time, and good biocompatibility

Inactive Publication Date: 2019-01-01
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the small water channel (<4nm) of cubic liquid crystal severely limits its further application. Since the molecular diameter of many protein drugs is larger than the size of its water channel, it is difficult to release. Most studies only use it as a carrier of small molecule compounds, and rarely use it. For macromolecular protein drugs
So far, there are no reports about the application of VEGF lyotropic liquid crystals in soft tissue regeneration to promote angiogenesis

Method used

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  • Lyotropic liquid crystal injection for soft tissue regeneration and vascularization promotion and preparation method thereof
  • Lyotropic liquid crystal injection for soft tissue regeneration and vascularization promotion and preparation method thereof
  • Lyotropic liquid crystal injection for soft tissue regeneration and vascularization promotion and preparation method thereof

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Embodiment 1～5、 comparative example 1～4

[0056] The present invention provides a lyotropic liquid crystal injection for soft tissue regeneration and vascularization promotion. The components of Examples 1-5 and Comparative Examples 1-4 are shown in Table 1.

[0057] Table 1 embodiment 1~5 and comparative example 1~4 prescription composition

[0058]

[0059] The preparation method of the above-mentioned lyotropic liquid crystal injection for soft tissue regeneration and vascularization is as follows:

Embodiment 1～4

[0061] According to the composition of Examples 1 to 4 in Table 1, the hydration regulator (wherein Examples 1 to 3 are octyl glucoside OG, and Example 4 is hexyl-β-D-glucopyranoside) was dissolved in N, N-dimethylacetamide (DMAC); dissolving vascular endothelial growth factor in aqueous solution; mixing molten lipid with N,N-dimethylacetamide solution of octyl glucoside to form a liquid crystal carrier; finally mixing the liquid crystal carrier with The vascular endothelial growth factor aqueous solution was mixed and shaken until clear and transparent, and the lyotropic liquid crystal precursor solutions of Examples 1-4 were obtained.

Embodiment 5～6

[0065] According to the composition of Examples 5-6 in Table 1, octyl glucoside was dissolved in ethanol (EtOH); vascular endothelial growth factor was dissolved in an aqueous solution; molten lipid was mixed with an ethanol solution of octyl glucoside to form a liquid crystal carrier; Finally, the liquid crystal carrier was mixed with the aqueous solution of vascular endothelial growth factor, and shaken until clear and transparent, thus obtaining the lyotropic liquid crystal precursor solutions of Examples 5-6.

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Abstract

The invention provides a carrier of lyotropic liquid crystal injection. The carrier is prepared from the following raw materials in parts by weight: 40 to 90 parts of a lipid matrix, 10 to 30 parts ofan organic solvent and 10 to 40 parts of a hydration regulation agent, wherein the hydration regulation agent is at least one of octyl-glucoside, hexyl-beta-D-glucopyranoside, dodecyl-beta-D-maltoside sucrose stearate, cholesterol and polyglycerol ester. According to the carrier, the pore diameter of a cubic liquid crystal water channel is enlarged through pore expansion of the hydration regulation agent, and vascular endothelial growth factors are continuously slowly released for one week, the action time of protein medicines is prolonged and the action is remarkably enhanced.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a lyotropic liquid crystal injection for soft tissue regeneration and angiogenesis promotion and a preparation method thereof. Background technique [0002] Soft tissue defects caused by trauma, congenital deformity, surgery and other reasons not only affect the appearance of the patient, but also have a certain impact on the mental health of the patient, and even damage the body function in severe cases. At present, skin flaps or tissue transplantation are mainly used to repair soft tissue defects clinically. However, this type of surgical method also has obvious deficiencies, such as complicated operation, high cost, increased suffering for patients, and the limited amount of transplanted tissue at the donor site, which is prone to immune rejection and inflammatory reactions. Therefore, there is a great clinical need to develop an ideal soft tis...

Claims

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Application Information

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IPC IPC(8): A61K9/127A61K47/26A61K45/00A61P9/00A61P19/04
CPCA61K9/0019A61K9/1274A61K45/00A61K47/26A61P9/00A61P19/04
Inventor 吴传斌王倍黄莹潘昕
Owner SUN YAT SEN UNIV
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