Malic acid bicarbonate in vitro hemodialysis agent

An extracorporeal blood and bicarbonate technology, applied in the field of medical blood purification treatment, can solve the problems of promoting the production of inflammatory factors, chronic metabolic acidosis, peritoneal fibrosis, etc., and achieve the goal of promoting the production of inflammatory factors, eliminating acidosis, Headache relief effect

Inactive Publication Date: 2019-01-01
刘成其
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since it also contains HCO 3 - with Ca 2+ and Mg 2+ Plasma, when the pH value is not good, it is easy to form calcium and magnesium salt precipitation. In order to prevent precipitation, the traditional formula is to add 3-8mmol/L acetic acid, acetate (Ac - ) becomes HCO after being metabolized by the human liver 3 - , It usually takes 3-5 hours to complete

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Example 1, weigh 1192.4g of sodium chloride (NaCl), 43.1g of potassium chloride (KCl), calcium chloride (CaCl 2 2H 2 O) 42.5g, magnesium chloride (MgCl 2 ·6H 2 O) 18.7g, levorotatory apple (C4H6O5) 54.2g, mix evenly, and then make component A of solid dosage form; weigh sodium bicarbonate (NaHCO 3 ) 385.0g, which is the component B of the solid dosage form (component B in this example does not contain sodium chloride); dissolve and dilute the component A of the solid dosage form with purified water to 5500 ml, add purified water to dissolve and dilute component B To 7000 milliliters, that is to make component A and component B of the liquid dosage form. According to the ratio of A:B:water=1:1.26:32.74, use a dialysis machine to inhale component A, component B and pure water, and the final ion concentration (mmol / L) of the mixture is: Na + 135.K + 2.5, Ca 2+ 1.5, Mg 2+ 0.5 、Cl - 112.2, MA 2.8, HCO 3 - 32, pH7.2.

Embodiment 2

[0025] Example 2, weigh sodium chloride (NaCl) 885.5g, potassium chloride (KCl) 22.7g, calcium chloride (CaCl 2 2H 2 O) 53.4g, magnesium chloride (MgCl 2 ·6H 2 O) 30.3g, L-malic acid (C4H6O5) 102.2g, mix well, and then make component A of solid dosage form; weigh sodium bicarbonate (NaHCO 3 ) 363.0g, sodium chloride (NaCl) 167.7g, mix evenly to form component B of solid dosage form; dissolve and dilute component A of solid dosage form with purified water to 5500ml, and dissolve component B with purified water to 7000ml Milliliters, that is, component A and component B made into a liquid dosage form. According to the ratio of A:B:water=1:1.83:34, use the dialysis machine to inhale component A, component B and pure water, the final ion concentration (mmol / L) of the mixture is: Na + 138.K + 2.0, Ca 2+ 2.0, Mg 2 + 0.75 、Cl - 110.5, MA 4.5, HCO 3 - 30, pH 7.3.

Embodiment 3

[0026] Example 3, weigh 1159.3g of sodium chloride (NaCl), 41.9g of potassium chloride (KCl), 41.9g of calcium chloride (CaCl 2 2H 2 O) 41.3g, magnesium chloride (MgCl 2 ·6H 2 O) 15.3g, L-malic acid (C4H6O5) 52.7g, mix well, and then make component A of solid dosage form; weigh sodium bicarbonate (NaHCO 3 ) 394.3, component B of the solid dosage form (component B in this example does not contain sodium chloride); dissolve and dilute component A of the solid dosage form with purified water to 5500 ml, and dissolve and dilute component B with purified water to 7000 ml, that is, component A and component B made into a liquid dosage form. According to the ratio of A:B:water=1:1.225:32.775, use a dialysis machine to inhale component A, component B and pure water, and the final ion concentration (mmol / L) of the mixture is: Na + 138.K + 2.0, Ca 2+ 1.75, Mg 2+ 0.5, Cl - 109, MA 2.8, HCO 3 - 35, pH 7.25.

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PUM

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Abstract

The invention relates to a malic acid bicarbonate in vitro hemodialysis agent, which comprises a component A and a component B, wherein the component A comprises, by weight, 77-95% of sodium chloride,0-4% of potassium chloride, 2-6% of calcium chloride, 1-3% of magnesium chloride, and 2-10% of L-malic acid, the component B comprises, by weight, 60-100% of sodium bicarbonate, and 0-40% of sodium chloride, and during the use, the final Na<+> concentration is 133-145 mmol/L, the final K<+> concentration is 0-4.0 mmol/L, the final Ca<2+> concentration is 1.0-2.0 mmol/L, the final Mg<2+> concentration is 0.3-1.0 mmol/L, the final Cl<-> concentration is 100-130 mmol/L, the final HCO3<-> concentration is 25-45 mmol/L, and the final H2MA concentration is 2-8 mmol/L. According to the present invention, the malic acid bicarbonate in vitro hemodialysis agent can solve the adverse reactions caused by the acetate radical in traditional hemodialysis agent to patients, can adjust the pH value withina suitable range, can protect the heart function, the liver function, the residual renal function and the normal cells of patients, and is suitable for blood purification and dialysis treatment.

Description

technical field [0001] The invention relates to the field of medical blood purification treatment, in particular to a bicarbonate extracorporeal hemodialysis preparation containing L-malic acid. Background technique [0002] The bicarbonate extracorporeal hemodialysis agent commonly used in the medical industry is mainly composed of sodium chloride (NaCl), potassium chloride (KCl), calcium chloride (CaCl) 2 ), magnesium chloride (MgCl 2 ), acetic acid (HAc), sodium bicarbonate (NaHCO 3 ) or sodium chloride (NaCl). Since it also contains HCO 3 - with Ca 2+ and Mg 2+ Plasma, when the pH value is not good, it is easy to form calcium and magnesium salt precipitation. In order to prevent precipitation, the traditional formula is to add 3-8mmol / L acetic acid, acetate (Ac - ) becomes HCO after being metabolized by the human liver 3 - , It usually takes 3-5 hours to complete, during which some patients have symptoms such as headache, dizziness, nausea, vomiting, convuls...

Claims

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Application Information

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IPC IPC(8): A61K33/14A61K9/08A61P7/08A61K33/06A61K31/194A61K33/00
CPCA61K33/14A61K9/08A61K31/194A61K33/00A61K33/06A61K2300/00
Inventor 刘成其
Owner 刘成其
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