Sodium alginate-chitosan poly-ion composite hydrogel and preparation method thereof

A technology of polyion complex and sodium alginate, which is applied in the field of biomedical materials, can solve the problems of low mechanical strength of hydrogel, inability to match mechanical strength, and unstable existence of hydrogel, so as to achieve mild reaction conditions and realize The effect of controllable operation

Inactive Publication Date: 2019-01-04
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The sodium alginate-calcium ion cross-linked hydrogel was constructed by using the chelation between the carboxylate groups on the molecular chain of sodium alginate and calcium ions. Due to its fast gelation speed, good lubricity and good biocompatibility, It is widely used in the study of cartilage repair hydrogels, but the hydrogels prepared by this method are easily replaced by other ions in the body, so the hydrogels cannot exist stably in the body, and the water prepared by this method Gel usually has low mechanical strength and cannot match the mechanical strength of cartilage tissue itself, thus affecting the repair process of cartilage tissue

Method used

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  • Sodium alginate-chitosan poly-ion composite hydrogel and preparation method thereof
  • Sodium alginate-chitosan poly-ion composite hydrogel and preparation method thereof
  • Sodium alginate-chitosan poly-ion composite hydrogel and preparation method thereof

Examples

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Effect test

Embodiment 1

[0046] Take 2.5g of sodium alginate powder (Aladdin, S100126) and add it to 50mL of deionized water, and use a magnetic stirrer at room temperature to Fully stir for 2 hours to obtain a sodium alginate solution with a mass volume percentage concentration of 5% (w / v), then add 2.5g of chitosan powder (Aladdin, deacetylation degree ≥ 95%), and continue to fully stir for 2 hours to make the chitosan The powder is evenly dispersed in the sodium alginate solution to prepare a sodium alginate-chitosan polyion complex with a mass volume percentage concentration of 10% (w / v) and a mass ratio of sodium alginate to chitosan of 1:1 solution.

[0047]Inject the sodium alginate-chitosan polyion complex solution into a cylindrical mold, soak in 500 mL of hydrochloric acid solution with a molar concentration of 1mol / L for 20 hours, until sodium alginate reacts with chitosan to obtain sodium alginate- Chitosan polyion complex hydrogel, sodium alginate-chitosan polyion is prepared by ionic c...

Embodiment 2

[0049] Take 3.75g of sodium alginate (Aladdin, S100126) powder and add it to 50mL of deionized water, and use a magnetic stirrer at room temperature to Fully stir for 3 hours to obtain a sodium alginate solution with a mass volume percentage concentration of 7.5% (w / v), then add 3.75g of chitosan (Aladdin, deacetylation degree ≥ 95%) powder, continue to stir for 4 hours to make the chitosan The powder is evenly dispersed in the sodium alginate solution to prepare a sodium alginate-chitosan polyion complex with a mass volume percentage concentration of 15% (w / v) and a mass ratio of sodium alginate to chitosan of 1:1 solution.

[0050] Inject the sodium alginate-chitosan polyion complex solution into a cylindrical mold, soak in 500 mL of hydrochloric acid solution with a molar concentration of 1mol / L for 20 hours, until sodium alginate reacts with chitosan to obtain sodium alginate- Chitosan polyion complex hydrogel, sodium alginate-chitosan polyion is prepared by ionic cross-...

Embodiment 3

[0052] Take 5g of sodium alginate (Aladdin, S100126) powder and add it to 50mL of deionized water, and use a magnetic stirrer at room temperature to Fully stir for 4 hours to obtain a sodium alginate solution with a mass volume percentage concentration of 10% (w / v), then add 5g of chitosan (Aladdin, deacetylation degree ≥ 95%) powder, and continue to fully stir for 4 hours to make the chitosan powder Uniformly dispersed in sodium alginate solution to prepare a sodium alginate-chitosan polyion complex solution with a mass volume percent concentration of 20% (w / v) and a mass ratio of sodium alginate to chitosan of 1:1 .

[0053] Inject the sodium alginate-chitosan polyion complex solution into a cylindrical mold, soak in 500 mL of hydrochloric acid solution with a molar concentration of 1mol / L for 20 hours, until sodium alginate reacts with chitosan to obtain sodium alginate- Chitosan polyion complex hydrogel, sodium alginate-chitosan polyion is prepared by ionic cross-linking...

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Abstract

The invention discloses sodium alginate-chitosan poly-ion composite hydrogel and a preparation method thereof. By means of the preparation method, the concentration of a sodium alginate-chitosan poly-ion composite solution is greatly increased, the number of ion pairs capable of reacting is increased, accordingly, the mechanical strength of the hydrogel is improved, it is achieved that the preparation process of the hydrogel is controllable, and the hydrogel in different shapes can be prepared by designing the shapes of molds according to the actual needs. The preparation method is mild in condition, chemical substances, such as a cross-linking agent and a photoinitiator are not needed, the mechanical strength of the sodium alginate-chitosan poly-ion composite hydrogel prepared by using the method can reach 1.8 MPa, and the sodium alginate-chitosan poly-ion composite hydrogel has a good application prospect.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a sodium alginate-chitosan polyion complex hydrogel and a preparation method thereof. Background technique [0002] Sodium alginate is a polyanionic polysaccharide sodium salt extracted from brown algae, composed of β-D-mannuronic acid and α-L-guluronic acid, which has good biocompatibility, lubricity and non-immune Originality. The carboxyl group on the molecular chain of sodium alginate can interact with cationic or polycationic polymer chains to form ionic crosslinks to prepare hydrogels. [0003] Hydrogel is a three-dimensional cross-linked network structure formed by cross-linking macromolecules. Due to the presence of hydrophilic groups on the macromolecular chains, the hydrogel contains a large amount of water, which is comparable to viscoelastic cartilage tissue. Similar and therefore used as a scaffold material for cartilage tissue repair. Hydrogels can b...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08J3/24C08L5/04C08L5/08
CPCC08J3/075C08J3/246C08J2305/04C08J2305/08C08J2405/04C08J2405/08
Inventor 曹晓东刘琼琼郑秋坚
Owner SOUTH CHINA UNIV OF TECH
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