Preparation method of antimicrobial polymer brush with triple functions of anti-fouling, sterilization and release

A technology of polymer brush and function, which is applied in the field of antibacterial polymer brush and its preparation, can solve the problems of single function and narrow application range, and achieve the effect of good safety, simple method and widening application field

Inactive Publication Date: 2019-01-18
ZHEJIANG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The polymer brush obtained by the method of the above invention has only antibacterial function, single function, and narrow application range, while the multifunctional polymer brush obtained by the method of the present invention can make the antibacterial surface have antifouling-sterilization-release triple functions simultaneously, and has antibacterial and antibacterial properties. Antibacterial surfaces with triple functions of pollution-sterilization-release will be the current research trend

Method used

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  • Preparation method of antimicrobial polymer brush with triple functions of anti-fouling, sterilization and release
  • Preparation method of antimicrobial polymer brush with triple functions of anti-fouling, sterilization and release
  • Preparation method of antimicrobial polymer brush with triple functions of anti-fouling, sterilization and release

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] (1) Treat the silicon wafer with an oxygen plasma surface processor for 2 minutes, then place the processed silicon wafer in a toluene solution with (2-bromo-2-methylpropionyloxypropyl)trimethoxysilane dissolved in it Soak for 24h;

[0052] (2) Take 2 clean test tubes, numbered test tube 1 and test tube 2, add 0.35g DVBAPS, 1.5mL trifluoroethanol, 1.5mL deionized water, 7μL ligand Me to test tube 1. 6 TREN; add 7mg CuBr and 2 pieces of silicon wafers obtained in step (1) to test tube 2 in turn; both test tubes are deoxygenated and filled with nitrogen 3 times, and then nitrogen is blown for 30 minutes, then the liquid in test tube 1 is drawn out to test tube 2 with a syringe In the process, deoxygenate and fill nitrogen again 3 times, and react test tube 2 in a constant temperature shaking box at 25°C for 24 hours. After the reaction is completed, it is ultrasonically cleaned twice in brine and deionized water, and dried with nitrogen to obtain a poly DVBAPS brush;

[0053] ...

Embodiment 2

[0060] (1) Treat the silicon wafer with an oxygen plasma surface processor for 2 minutes, then place the processed silicon wafer in a toluene solution with (2-bromo-2-methylpropionyloxypropyl)trimethoxysilane dissolved in it Soak for 24h;

[0061] (2) Take 2 clean test tubes, number test tube 1 and test tube 2. Add 0.5g NIPAM, 1.5mL methanol, 1.5mL deionized water, 33μL ligand PMDETA to test tube 1; add 13mg CuBr and 2 tablets to test tube 2 in sequence The silicon wafer obtained in step (1); both test tubes are deaerated and filled with nitrogen 3 times, and after blowing nitrogen for 30 minutes, the liquid in test tube 1 is drawn into test tube 2 with a syringe, and the test tube is deaerated and filled with nitrogen 3 times again. 2 React in a constant temperature shaking box at 25°C for 12 hours. After the reaction is completed, perform ultrasonic cleaning twice in methanol, ethanol, and deionized water, and blow dry with nitrogen to obtain a polyNIPAM brush;

[0062] (3) Take...

Embodiment 3

[0065] (1) Treat the silicon wafer with an oxygen plasma surface processor for 2 minutes, then place the processed silicon wafer in a toluene solution with (2-bromo-2-methylpropionyloxypropyl)trimethoxysilane dissolved in it Soak for 24h;

[0066] (2) Take 2 clean test tubes, number test tube 1 and test tube 2, add 0.54gMAA and 3.0mL deionized water to test tube 1; add 43mg ligand Bpy and 11mg CuBr / CuBr to test tube 2 2 (m:m=1:1) mixture and 2 pieces of silicon wafers obtained in step (1); both test tubes are deoxygenated and filled with nitrogen 3 times, and then nitrogen is blown for 30 minutes, and then the liquid in test tube 1 is drawn out with a syringe Into test tube 2, deoxygenate and nitrogenate again 3 times. Test tube 2 was reacted in a constant temperature shaking box at 25°C for 12 hours. After the reaction was completed, it was ultrasonically cleaned twice in ethanol and deionized water, and dried with nitrogen to obtain a polyMAA brush;

[0067] (3) Take 2 clean test...

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Abstract

The invention discloses a preparation method of an antimicrobial polymer brush with triple functions of anti-fouling, sterilization and release. The preparation method comprises the following steps: 1) an active free radical initiator is grafted onto the surface of a backing material; 2) the backing material grafted with the initiator is polymerized with a stimulus-responsive monomer for obtaininga responsive polymer brush; 3) the responsive polymer brush is polymerized with a hydrophilic monomer for obtaining a hydrophilic responsive polymer brush; and 4) the hydrophilic responsive polymer brush is grafted with a trichloromethane antimicrobial agent or loaded with silver nanoparticles for obtaining the antimicrobial polymer brush. The polymer brush obtained with the method provided by the invention has the triple functions of anti-fouling, sterilization and release, and the antimicrobial surface is endowed with multiple functions of long-term anti-fouling, high-efficiency sterilization and bacteria release, thereby greatly expanding the application field.

Description

Technical field [0001] The invention relates to the technical field of preparation of an antibacterial surface, in particular to an antibacterial polymer brush with anti-fouling-sterilization-release triple functions and a preparation method thereof. Background technique [0002] Bacteria are widely present in nature and human production and living environment, seriously affecting people's health and life safety. Bacterial infection and spread are mainly the process of bacteria attaching and multiplying on the surface of the material. In this process, the bacteria first adhere to the surface of the material, and then form a cell biofilm by secreting extracellular matrix. The formation of cell biofilm will be greatly improved. The resistance of bacteria to antibiotics, fungicides and the human immune system. Therefore, the key to fighting bacterial infections is to prevent bacterial adhesion and the formation of cell biofilms. [0003] The polymer brush is a high-density polymer mo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F285/00C08F292/00C08F8/18
CPCC08F8/18C08F285/00C08F292/00C08F2438/03
Inventor 杨晋涛汪扬吴家慧钟明强陈枫范萍
Owner ZHEJIANG UNIV OF TECH
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