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A porous water-soluble sulfide photothermal conversion nanomaterial applicable to tumor photothermal therapy and its hydrothermal synthesis method

A nanomaterial, water-soluble technology, applied in the field of nanomaterials, achieves the effects of good water solubility and porous structure, easy modification, and good tumor photothermal treatment effect

Active Publication Date: 2020-12-01
CAPITAL NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the method of using small biomolecules as soft templates to synthesize porous sulfide photothermal conversion nanomaterials and apply them to tumor photothermal therapy has not been reported yet.

Method used

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  • A porous water-soluble sulfide photothermal conversion nanomaterial applicable to tumor photothermal therapy and its hydrothermal synthesis method
  • A porous water-soluble sulfide photothermal conversion nanomaterial applicable to tumor photothermal therapy and its hydrothermal synthesis method
  • A porous water-soluble sulfide photothermal conversion nanomaterial applicable to tumor photothermal therapy and its hydrothermal synthesis method

Examples

Experimental program
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Effect test

Embodiment 1

[0041] Example 1, porous, water-soluble Co 9 S 8 Preparation of nanospheres

[0042] 5mmol Co(NO 3 ) 2 ·6H 2 O was dissolved in 12mL deionized water, then 2.5mmol sodium thiosulfate and 0.034g salmon sperm DNA were added, and after stirring at room temperature for 10 minutes, the mixed solution was put into a 50mL autoclave under 24MPa pressure and 150°C. Hydrothermal reaction, take it out after 12 hours, cool down to room temperature, centrifuge, remove the supernatant; add an appropriate amount of deionized water to the solid, ultrasonically disperse, and then centrifuge; repeat the above steps, and continue to wash with deionized water for several times , the porous, water-soluble Co 9 S 8 nanospheres.

[0043] The resulting porous, water-soluble Co 9 S 8 The nanospheres were activated at 90°C for 5h. Nitrogen adsorption and desorption curves and specific surface area are both in the low pressure range (P / P 0 = 0.01) was measured using the BET model, and the pore...

Embodiment 2

[0051] Embodiment 2, porous, water-soluble Cu 1.96 Preparation of S nanoparticles

[0052] 5mmol Cu(NO 3 ) 2 Dissolve in 12mL deionized water, then add 2.5mmol sodium thiosulfate and 0.034g disodium uridylate, stir at room temperature for 10 minutes, put the mixed solution in a 50mL autoclave under 24MPa pressure, 180℃ for water Heat reaction, take it out after 8 hours, cool down to room temperature, centrifuge, remove the supernatant; add an appropriate amount of deionized water to the solid, ultrasonically disperse, and then centrifuge; repeat the above steps, continue to wash with deionized water several times, Porous, water-soluble Cu can be obtained 1.96 S nanoparticles.

[0053] The resulting porous, water-soluble Cu 1.96 S nanoparticles were activated at 90 °C for 5 h. Nitrogen adsorption and desorption curves and specific surface area are both in the low pressure range (P / P 0 = 0.01) was measured using the BET model, and the pore size was measured using the BJH ...

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Abstract

The invention discloses a porous water-soluble sulfide photothermal-conversion nanomaterial applicable to photothermal therapy of tumors, and a hydrothermal synthesis method thereof. The synthesis method for the porous water-soluble sulfide nanomaterial comprises the following steps: preparing a mixed aqueous solution of a metal compound, a sulfur-containing compound and a biological small molecule, and performing a hydrothermal reaction so as to obtain the porous water-soluble sulfide nanomaterial. According to the invention, the biological small molecule is added as a soft template to assistin the preparation of the water-soluble sulfide photothermal-conversion nanomaterial with a porous structure; and since no surface ligand is used in the reaction process, the porous water-soluble sulfide photothermal-conversion nanomaterial prepared by using the method has a clean surface and is easy to modify. The water-soluble sulfide photothermal-conversion nanomaterial having the porous structure and applicable to photothermal therapy of tumors is prepared through hydrothermal synthesis and has good photothermal conversion performance and good photothermal treatment effect on tumors.

Description

technical field [0001] The invention relates to a porous water-soluble sulfide photothermal conversion nanomaterial applicable to tumor photothermal therapy and a hydrothermal synthesis method thereof, belonging to the field of nanomaterials. Background technique [0002] Photothermal conversion nanomaterials are special materials that can absorb near-infrared light and convert it into heat energy, and have good application prospects in tumor treatment. Due to the good biocompatibility and stability of sulfide nanomaterials, it can be used as a nanomedicine for tumor photothermal therapy. [0003] At present, the synthesis based on solvent polarity and ion exchange method has been reported, and Chinese scholars have made important contributions in this regard. For example, porous sulfide nanomaterials were prepared by solvothermal method (Zheng Z, Dalton Trans. 2013, 42, 5724) and hydrothermal method (ACS Appl. Mater. Interfaces 2016, 8, 9721). However, the method of using...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C01G3/12C01G51/00B82Y40/00A61K41/00A61P35/00
CPCA61K41/0052C01G3/12C01G51/30C01P2002/72C01P2004/04C01P2004/32C01P2004/64C01P2006/12C01P2006/14C01P2006/16
Inventor 周晶刘瑜鑫张戈
Owner CAPITAL NORMAL UNIVERSITY
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