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808 nanometer near-infrared excited composite antibacterial coating and preparation method thereof

A composite antibacterial and near-infrared technology, applied in the field of materials science and nanometers, can solve the problems of increased bacterial resistance, tissue burns, super bacteria, etc., and achieve the effects of convenient preparation, shortening treatment time, and improving antibacterial efficiency.

Active Publication Date: 2019-01-25
HUBEI UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0002] Bacterial infections caused during surgical implantation often cause many problems, and the most common solution is to treat them with antibiotics, but the abuse of antibiotics can lead to increased bacterial resistance and even the emergence of superbugs, resulting in a sharp decline in the therapeutic effect of antibiotics , therefore, drug controlled release is very important for local bacterial infection
But there is another problem that the effectiveness of antibiotics depends on the dose and the degree of infection
Photothermal therapy is to convert the energy of light in the near-infrared region into heat through photothermal materials to ablate bacteria, but local overheating for a long time will cause normal tissue burns

Method used

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  • 808 nanometer near-infrared excited composite antibacterial coating and preparation method thereof

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preparation example Construction

[0019] The second aspect of the present invention provides the preparation method of the above-mentioned 808 nanometer near-infrared excitation composite antibacterial coating, the steps include:

[0020] S1. Preparation of polyethylene glycol-modified molybdenum sulfide nanoflowers: Sodium molybdate dihydrate, thioacetamide, and polyethylene glycol were dissolved in deionized water and stirred to prepare a mixed solution A.

[0021] S2. Pour the mixed solution A described in step S1 into the reaction kettle with the titanium sheet, react at 190-220° C. for 23-25 ​​hours, and take out the titanium sheet for later use after the reaction is completed;

[0022] S3. Loading of antibiotics: the titanium sheet obtained in step S2 is dried and soaked in an antibiotic solution to load the drug to obtain the drug-loaded titanium sheet;

[0023] S4. Spin coating of chitosan: Adsorb the drug-loaded titanium sheet obtained in step S3 on a spin coater, and then spin coat the chitosan solut...

Embodiment 1

[0035] (1) Polish the pure titanium sheet with 240#, 400#, 600#, 800#, and 1200# sandpaper in sequence, then ultrasonically wash it with acetone, ethanol, and deionized water for 5 minutes, and dry it for later use.

Embodiment 2

[0037] (1) Polish the pure titanium sheet with 240#, 400#, 600#, 800#, and 1200# sandpaper in sequence, then ultrasonically wash it with acetone, ethanol, and deionized water for 5 minutes, and dry it for later use.

[0038] (2) Dissolve 20 mg of sodium molybdate dihydrate, 40 mg of thioacetamide and 0.66 g of polyethylene glycol in 40 mL of deionized water, and stir for 30 minutes to mix the solution evenly. The concentration of sodium molybdate dihydrate is 0.5 mg / mL, the concentration of thioacetamide is 1 mg / mL, and the concentration of polyethylene glycol is 0.0165 g / mL. Then pour the mixed solution into the reaction kettle with the treated titanium sheet in step one. The reaction kettle was placed in a muffle furnace at 200°C for 24 hours, and after natural cooling, the titanium sheet was taken out for use.

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Abstract

The invention relates to an 808 nanometer near-infrared excited composite antibacterial coating and a preparation method thereof. The invention utilizes a hydrothermal method to synthesize uniform size polyethylene glycol modified molybdenum sulfide nano-flowers in one pot. Furthermore, chitosan encapsulated in gentamicin loaded polyethylene glycol modified molybdenum sulfide nanoparticles slowedthe drug release rate. The advantages of the invention are: the petal-like molybdenum disulfide grown on titanium surface has a larger specific surface area which can increase the loading of gentamicin, Molybdenum disulfide itself has a good photothermal effect under near-infrared irradiation. The drug is released quickly under the photothermal effect. The synergistic effect of photothermal and gentamicin can achieve higher antibacterial efficiency in a short period of time.

Description

technical field [0001] The invention relates to the field of material science and nanotechnology, in particular to a composite antibacterial coating excited by 808nm near-infrared with photothermal effect and drug controlled release and a preparation method thereof. Background technique [0002] Bacterial infections caused during surgical implantation often cause many problems, and the most common solution is to treat them with antibiotics, but the abuse of antibiotics can lead to increased bacterial resistance and even the emergence of superbugs, resulting in a sharp decline in the therapeutic effect of antibiotics , therefore, drug controlled release is very important for local bacterial infection. But there is another problem that the effect of antibiotics depends on the dose and the degree of infection. Photothermal therapy is to convert the energy of light in the near-infrared region into heat through photothermal materials to ablate bacteria, but local overheating for...

Claims

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Application Information

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IPC IPC(8): A61K47/02A61K47/10A61K47/36A61K45/00A61K31/7036A61K41/00A61P31/04
CPCA61K31/7036A61K41/0052A61K45/00A61K47/02A61K47/10A61K47/36A61P31/04
Inventor 吴水林马梦雪刘想梅
Owner HUBEI UNIV
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