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Porous chitosan microsphere preparation method

A technology of porous chitosan and chitosan, which is applied in the field of preparation of porous chitosan microspheres, can solve the problems of complex preparation process, poor particle dispersion, limited adsorption effect, etc., and achieve the effect of uniform distribution of micropores

Active Publication Date: 2019-02-01
WUHAN INSTITUTE OF TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] At present, the common preparation methods of chitosan microspheres include chemical cross-linking method, spray drying method, ion exchange method, complex coacervation method, electrostatic spray method and emulsification cross-linking method, etc.; , limited adsorption effect, etc.

Method used

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  • Porous chitosan microsphere preparation method

Examples

Experimental program
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Embodiment 1

[0038] A preparation method of chitosan microspheres, comprising the following steps:

[0039] 1) Preparation of chitosan solution: chitosan (Mw 120000g·mol -1 ) was dissolved in acetic acid aqueous solution (2vol%), and the mass fraction of the preparation was 2% chitosan solution, sonicated at room temperature until completely dissolved, left standing to remove air bubbles, and a uniform and transparent chitosan solution was obtained;

[0040] 2) Preparation of emulsified dispersant: Mix 50 mL of liquid paraffin and 1 mL of Span-80, stir evenly to obtain emulsified dispersant;

[0041] 3) Preparation of nanoparticle solution: Dissolve 3g of anhydrous calcium chloride in 20ml of deionized water, then add 1.5g of PEG-600, and disperse evenly by ultrasonic to obtain a clear and transparent nanoparticle solution;

[0042] 4) Preparation of porous chitosan microspheres: at room temperature, add the emulsified dispersant obtained in step 2) into a 250ml round-bottomed flask and p...

Embodiment 2

[0046] A preparation method of chitosan microspheres, comprising the following steps:

[0047] 1) Preparation of chitosan solution: chitosan (Mw 150000g·mol -1 ) was dissolved in acetic acid aqueous solution (2vol%), and the mass fraction of the preparation was 2% chitosan solution, sonicated at room temperature until completely dissolved, left standing to remove air bubbles, and a uniform and transparent chitosan solution was obtained;

[0048] 2) Preparation of emulsified dispersant: mix 50 mL of liquid paraffin and 1.5 mL of Span-80, and stir evenly to obtain an emulsified dispersant;

[0049] 3) Preparation of nanoparticle solution: Dissolve 4g of anhydrous calcium chloride in 20ml of deionized water, then add 2g of PEG-600, and disperse evenly by ultrasonic to obtain a clear and transparent nanoparticle solution;

[0050] 4) Preparation of porous chitosan microspheres: at room temperature, add the emulsified dispersant obtained in step 2) into a 250ml round-bottomed flask ...

Embodiment 3

[0052] A preparation method of chitosan microspheres, comprising the following steps:

[0053] 1) Preparation of chitosan solution: chitosan (Mw 100000g·mol -1 ) was dissolved in acetic acid aqueous solution (2vol%), and the mass fraction of the preparation was 2% chitosan solution, sonicated at room temperature until completely dissolved, left standing to remove air bubbles, and a uniform and transparent chitosan solution was obtained;

[0054] 2) Preparation of emulsifying dispersant: mix 50 mL of liquid paraffin and 0.5 mL of Span-80, and stir evenly to obtain an emulsifying dispersant;

[0055] 3) Preparation of nanoparticle solution: Dissolve 2g of anhydrous calcium chloride in 20ml of deionized water, then add 1g of PEG-600, and disperse evenly by ultrasonic to obtain a clear and transparent nanoparticle solution;

[0056] 4) Preparation of porous chitosan microspheres: at room temperature, add the emulsified dispersant obtained in step 2) into a 250ml round-bottomed fl...

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Abstract

The invention discloses a porous chitosan microsphere preparation method, which comprises: adding a chitosan acetic acid solution and a nanoparticle solution into an emulsifying dispersing agent, andcompletely dispersing calcium ions around the chitosan molecules through mechanical stirring; adding a cross-linking agent, and adjusting the pH value, such that calcium hydroxide micro-particles aresynchronously formed during the cross-linking sphere formation of chitosan, and calcium hydroxide generates nano-scale particles under the template effect of PEG during the process, wherein the particles are attached to the chitosan microspheres and occupy a certain position; and after completing the cross-linking reaction, soaking the microsphere products by using hydrochloric acid to remove thecalcium hydroxide micro-particles so as to obtain the porous chitosan microspheres. According to the present invention, the synthesized chitosan microspheres have characteristics of large specific surface area and good dispersibility, and can easily promote the adsorption modification performance of the chitosan microspheres; and the preparation method has characteristics of simpleness, mild reaction conditions, low requirement on the equipment, simple subsequent treatment process and low cost, and is suitable for promotion application.

Description

technical field [0001] The invention belongs to the field of polymer materials and relates to a preparation method of porous chitosan microspheres. Background technique [0002] The chemical name of chitosan (Chitosan) is poly(1,4)-2-amino-2-deoxy-β-D glucan, which is the product of de-N-acetylation of chitin and can be obtained in large quantities in nature. One of the natural polymers. There are active hydroxyl and amino groups in the chitosan macromolecule, which has the characteristics of strong chemical reaction ability, good biocompatibility, microbial degradation and non-toxic degradation products. Chitosan is one of the few charged natural products with many unique physical and chemical properties and biological functions. Chitosan microspheres have made major breakthroughs and are widely used in different fields such as drug carriers, food processing, water quality treatment, bioengineering and micro-separators. Chitosan microspheres with different particle sizes ...

Claims

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Application Information

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IPC IPC(8): C08J9/26C08J3/24B01J13/14B01J20/26B01J20/28B01J20/30C08L5/08
CPCB01J13/14B01J20/046B01J20/24B01J20/267B01J20/28021C08J3/24C08J9/26C08J2201/0442C08J2305/08
Inventor 余军霞唐嘉齐池汝安陈佳东徐源来周芳
Owner WUHAN INSTITUTE OF TECHNOLOGY
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