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A low-intensity focused ultrasound-responsive phase-change thrombolytic nanoparticle, its application and its preparation method

A technology of focused ultrasound and nanoparticles, applied in the field of biomedicine, can solve the problems of limited drug loading, poor thrombolytic effect, low strength, etc., achieve good encapsulation and film formation, improve biological safety, and good stability sexual effect

Active Publication Date: 2021-09-28
THE SECOND AFFILIATED HOSPITAL OF CHONGQING MEDICAL UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] One of the purposes of the present invention is to provide a low-intensity focused ultrasound-responsive phase-change thrombolytic nanoparticle to solve the problem of poor thrombolytic effect caused by drug-loaded nanoparticles in the prior art due to limited drug loading or drug inactivation. The problem

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  • A low-intensity focused ultrasound-responsive phase-change thrombolytic nanoparticle, its application and its preparation method
  • A low-intensity focused ultrasound-responsive phase-change thrombolytic nanoparticle, its application and its preparation method
  • A low-intensity focused ultrasound-responsive phase-change thrombolytic nanoparticle, its application and its preparation method

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Embodiment Construction

[0056] The following is further described in detail through specific implementation methods:

[0057] One, the preparation method of the low-intensity focused ultrasound response type phase-change thrombolytic nanoparticles of the present invention, the specific steps are as follows:

[0058] (1) Preparation of Fe 3 o 4 -PLGA-PFH nanoparticles

[0059] Weigh 50mg of PLGA and dissolve in 2mL of dichloromethane, and add 0.2mL of PFH and oleic acid-modified Fe 3 o 4 The solution was emulsified for 60 s with an ultrasonic breaker, then 5 mL of 4% PVA solution was added, and the emulsification was continued for 60 s, and 10 mL of 2% isopropanol solution was added and magnetically stirred for 3 h under ice bath conditions. After centrifugation and washing, the Fe 3 o 4 - PLGA-PFH nanoparticles.

[0060] (2) Preparation of Fe 3 o 4 -PLGA-PFH-CREKA nanoparticles

[0061] Fe prepared in step (1) 3 o 4 - PLGA-PFH nanoparticles are dissolved in pH5.2, 0.1M MES buffer, appropr...

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Abstract

The invention relates to the technical field of biomedicine, and discloses a low-intensity focused ultrasound-responsive phase-change thrombolytic nanoparticle, comprising a shell polylactic acid-glycolic acid copolymer PLGA, and the shell is embedded with ferric iron tetroxide Fe 3 o 4 , the shell is wrapped with perfluorohexane PFH, and the shell is connected with CREKA polypeptide for targeting fibrin. The invention can solve the problem in the prior art that the drug-loaded nanoparticles have poor thrombolytic effect due to limited drug load or drug inactivation.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a low-intensity focused ultrasound responsive phase-change thrombolytic nanoparticle, its application and its preparation method. Background technique [0002] A thrombus is a small piece of blood that forms on the surface of a vessel in the cardiovascular system where the lining has been peeled off or repaired. In variable flow dependent patterns, thrombi consist of insoluble fibrin, deposited platelets, accumulated leukocytes, and trapped erythrocytes. [0003] Thrombosis is the main pathogenesis of acute ischemic cardiovascular disease and is the main cause of unstable angina, myocardial infarction and stroke. For a long time, because recombinant tissue plasminogen activator (rtPA) can activate plasminogen, and then dissolve thrombus, it is a commonly used drug in the field of thrombolysis, so patients with thrombosis mainly use recombinant tissue plasminogen activator (r...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K49/22A61K49/18A61K49/12A61K41/00A61K9/51A61K47/34A61K47/18A61P7/02
CPCA61K9/5123A61K9/5153A61K41/0028A61K49/12A61K49/1878A61K49/225A61P7/02
Inventor 钟毅欣郭大静周君徐杰叶曼何晓静宋卫香候静馨刘佳
Owner THE SECOND AFFILIATED HOSPITAL OF CHONGQING MEDICAL UNIV
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