A kind of curcumin composite nanoparticle and preparation method thereof

A technology of composite nanoparticles and curcumin, which is applied in the directions of pharmaceutical combinations, pharmaceutical formulations, medical preparations of inactive ingredients, etc., to achieve the effects of simple operation process, improved yield per unit time, and good solubility

Active Publication Date: 2021-06-01
MEDONCARE PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although curcumin nanoparticles prepared by the above-mentioned supercritical crystallization technology have a certain effect in increasing the water solubility and dissolution rate of drugs, curcumin, as a substrate of P-glycoprotein in vivo, is easily excreted from cells, so it further inhibits P-glycoprotein. Glycoproteins to enhance curcumin bioavailability and efficacy remain unresolved issues

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0028] A method for preparing curcumin composite nanoparticles, comprising the steps of:

[0029] S1, add curcumin and piperine to the liquefied CO2, and disperse evenly to obtain a mixture; the mass ratio of curcumin and piperine is 40:1-100:1;

[0030] S2. Pump the mixture obtained in step S1 into the high-pressure crystallization kettle, adjust the temperature to a preset temperature of 25-40° C., adjust the pressure to a preset pressure of 15-30 MPa, and inject it into the high-pressure crystallization kettle at a flow rate of 3 ml / min. Pump in the plant polysaccharide aqueous solution; the concentration of the plant polysaccharide aqueous solution is 20-100mg / ml; the plant polysaccharide in the plant polysaccharide aqueous solution is one or more of tea polysaccharide, wolfberry polysaccharide, konjac polysaccharide, jujube polysaccharide, soybean polysaccharide and polydextrose ; Wherein, the amount of pumping the plant polysaccharide aqueous solution ensures that the ma...

Embodiment 1

[0033] Disperse curcumin and piperine into liquefied CO in the dark 2 In, the mass ratio of curcumin and piperine is 100:1. will CO 2 (contains curcumin and piperine) pumped into the autoclave, after the temperature of the autoclave reaches the preset value of 25°C and the pressure is 15MPa and stabilizes for 5min, the tea with a concentration of 20mg / ml is pumped in at a flow rate of 3ml / min Polysaccharide aqueous solution, wherein the mass ratio of tea polysaccharide and curcumin is 10:1. After the solution is pumped, continue to pass through the CO 2 After 0.5h, stop feeding CO 2 , release the pressure, and collect the particles in the reactor to obtain curcumin composite nanoparticles. Its average particle diameter is 250nm, and the encapsulation efficiency is 93%.

Embodiment 2

[0035] Disperse curcumin and piperine into liquefied CO in the dark 2 In, the mass ratio of curcumin and piperine is 40:1. will CO 2 (containing curcumin and piperine) is pumped into the autoclave, and after the temperature of the autoclave reaches 25° C. and the pressure is the preset value of 15 MPa and stabilizes for 5 minutes, the polymer concentration of 100 mg / ml is pumped in at a flow rate of 3 ml / min. Glucose and soybean polysaccharide aqueous solution (the mass ratio of polydextrose and soybean polysaccharide is 1:1), wherein the mass ratio of plant polysaccharide and curcumin is 50:1. After the solution is pumped, continue to pass through the CO 2 After 0.5h (that is, the water is dry), stop feeding CO 2 , release the pressure, and collect the particles in the reactor to obtain curcumin composite nanoparticles. Its average particle size is 310nm, and the encapsulation efficiency is 95%.

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Abstract

The invention belongs to the field of curcumin preparation, and in particular relates to a curcumin composite nano particle and a preparation method thereof. Wherein, the following substances are included in parts by weight: 40-100 parts of curcumin, 1 part of piperine, and 400-5000 parts of plant polysaccharides. The preparation method comprises the following steps: S1, adding curcumin and piperine to liquefied CO2, and dispersing them uniformly to obtain a mixture; S2, pumping the mixture obtained in step S1 into a high-pressure crystallization kettle, and adjusting the temperature and pressure to preset values Finally, pump the plant polysaccharide aqueous solution into the high-pressure crystallization kettle; S3, pass CO2 into the high-pressure crystallization kettle, and maintain the temperature and pressure in the high-pressure reaction kettle until the water is dried, and stop pumping CO 2 , and the dry sample was obtained after the pressure was reduced to normal pressure. In the whole preparation process, the process time is short, no organic solvent is used, and the prepared product has better bioavailability and curative effect.

Description

technical field [0001] The invention belongs to the field of curcumin preparation, and in particular relates to a curcumin composite nano particle and a preparation method thereof. Background technique [0002] Curcumin is a natural pigment extracted from turmeric, a plant of the Zingiberaceae family. It is currently mainly used in the food field as an edible pigment instead of synthetic dyes. Curcumin has a long history as a medicine. Traditional Chinese medicine records that curcumin is pungent, bitter, warm in nature, non-toxic, and can promote blood circulation, promote qi, stimulate menstruation, and relieve pain. Modern medicine has further proved the pharmacological effects of curcumin, such as anti-oxidation, anti-tumor, anti-inflammatory, anti-microbial, etc. [Research progress of curcumin. Chinese herbal medicine 2009, 40 (5), 828-831]. Recent studies have found that curcumin has a significant effect on treating chronic diseases such as cardiovascular and cerebrov...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/51A61K47/36A61K47/04A61K31/12A61K31/4525A61K31/715A61P39/06A61P35/00A61P29/00A61P31/00A61P9/00A61P25/24A61P3/10A61P37/02
CPCA61K9/5115A61K9/5161A61K31/12A61K31/4525A61K31/715A61P3/10A61P9/00A61P25/24A61P29/00A61P31/00A61P35/00A61P37/02A61P39/06A61K2300/00
Inventor 刘晓忠靳奇峰郑和校李郡李楚雄
Owner MEDONCARE PHARMA CO LTD
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