Miniaturized portable mass spectrometer and ion source device for generating water cluster ions

Abstract

The invention discloses an ion source device for generating water cluster ions. Starting with a solution parameter direction which plays a decisive role in the whole spraying process, under the premise that the electrospray ion source itself has no heating device, based on a cutting surface of a quartz capillary spray outlet and the environment in which the spray outlet is located, the capillary section is highly flat, smooth and hairless, and the volume of the droplet is controlled and stable spray is generated, thereby effectively performing the desolvation process. A mass spectrometer sample injection-grade cavity body is adopted to prevent the influence and interference of the external environment (wind, dust in the air, etc.) on the ion spray intensity. By adopting the two measures, certain effects are achieved on improving the efficiency of electrospray and reducing the detection limit of the instrument. The device has the advantages of simple structure, small volume, capabilityof keeping stable during the detection process, high sensitivity and stability, and convenient adjustment of the height and distance of the mist outlet. The invention also discloses a miniaturized portable mass spectrometer using the above ion source device.

Description

technical field [0001] The invention relates to the technical field of mass spectrometer systems, in particular to an electrospray ionization source device integrated in a miniaturized portable mass spectrometer, and in particular to an ion source device for generating water cluster ions. Background technique [0002] Mass spectrometry has high sensitivity in substance analysis and detection, and is one of the most widely used analytical techniques in the world. At present, mass spectrometer has become an essential analytical instrument in many fields, and plays an increasingly important role in many hot fields such as pharmaceuticals, life sciences, environmental monitoring and protection, food safety, doping detection, border security inspection, aerospace and military technology. role. A complete set of mass spectrometer generally consists of ion source, ion transmission part, mass analyzer, detector, vacuum system, circuit control and data acquisition system and other p...

AI Technical Summary

Problems solved by technology

During the formation of sample ions, if ion clusters cannot be vaporized and separated sufficiently, the ionization efficiency of the sample will be reduced

In many commercial instruments, the sensitivity is improved by heating the auxiliary gas or wrapping a heating tape outside the ion transmission device. Although these methods can improve the sensitivity of the ion source to varying degrees, they are either too complicated or greatly increase the instrument’s sensitivity. The volume is not conducive to the miniaturization research of mass spectrometry instruments

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