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Bioactive stent of hotdog-like structure and preparation method and application thereof

A bioactive, layered structure technology, applied in the fields of manufacturing tools, additive manufacturing, tissue regeneration, etc., can solve the problems of low porosity, low drug loading efficiency, unable to form continuous pore structure, etc. Beneficial effects on adhesion and proliferation and differentiation effects, excellent drug release properties

Active Publication Date: 2019-03-01
中科硅诺(太仓)生物材料科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At the same time, traditional 3D printed bioscaffolds are made of solid primitives stacked layer by layer. Most of the scaffolds are solid structures with relatively low porosity and low drug loading efficiency, and the pores cannot form a continuous channel structure. Studies have shown that if the material has a large specific surface area in bone repair materials, it is more conducive to the storage of nutrients and cells[7,8]

Method used

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  • Bioactive stent of hotdog-like structure and preparation method and application thereof
  • Bioactive stent of hotdog-like structure and preparation method and application thereof
  • Bioactive stent of hotdog-like structure and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0067] Take 5g of pure feldspar powder (purchased from Kunshan Huaqiao Technology New Material Co., Ltd.), 0.32g of sodium alginate powder and 2.5g of F127 aqueous solution with a mass fraction of 20%, after fully mixing, use 3D printing technology to prepare a hollow tube 3D printing bracket .

[0068] The printed scaffold was calcined at 1350°C for 3 hours to obtain a pure hollow tube 3D printed scaffold HT-AKT.

[0069] Preparation of ice template slurry: the mass fraction of feldspar in aqueous solution is 20%, 30%, 40%, and 50%, respectively, the mass fraction of sodium polyacrylate is 1.5%, and the mass fraction of PVA is 1.5%. Ball mill at 500r / min for 1.5h.

[0070] Place the hollow tube support (HT-AKT) in the mold containing the above-mentioned feldspar ice template slurry, use the ice template method, and use a one-way cold source at -70 to -80°C to freeze, so that the slurry grows into the hollow in the pipeline. Freeze-dry the obtained green body for 36 hours, ta...

Embodiment 2

[0093] Take 5g of pure β-TCP powder (purchased from Kunshan Huaqiao Technology Co., Ltd.), 0.22g of sodium alginate powder and 1.5g of F127 aqueous solution with a mass fraction of 30% are fully mixed, and then use 3D printing technology to prepare single-channel empty tube 3D printing stand.

[0094] The printed scaffold was calcined at 11000°C for 3 hours to obtain a pure single-channel 3D printed scaffold.

[0095] Prepare ice template slurry: the mass fraction of β-TCP in aqueous solution is 10%-50%, the mass fraction of sodium polyacrylate is 1%-3%, and the mass fraction of PVA is 4%-5%. Ball mill at 500r / min for 1.5-5h.

[0096] The single-channel β-TCP scaffold is placed in a mold containing 10%-50% β-TCP ice-template slurry, and the ice-template method is used to make the slurry grow into the hollow channel. The obtained green body is freeze-dried for 24-48 hours, and the scaffold embedded in the green body block is taken out and sintered at 1100° C. for 3-5 hours to...

Embodiment 3

[0098] Take 6g of pure feldspar powder, 0.3g of sodium alginate powder and 1.5g of F127 aqueous solution with a mass fraction of 20% and mix thoroughly, and then use 3D printing technology to prepare a hollow tube 3D printed scaffold.

[0099] The printed scaffold was calcined at 1350°C for 3 hours to obtain a pure hollow tube 3D printed scaffold HT-AKT.

[0100] Prepare ice template slurry: the mass fraction of graphene oxide (GO) (purchased from Haoye Co., Ltd.) in aqueous solution is 5-20%, the mass fraction of sodium polyacrylate is 1.5%-2.5%, and the mass fraction of PVA is 3 %-6%, the slurry is ball-milled for 1.5-2h in a high-energy ball mill at 500r / min.

[0101] The hollow tube support (HT-AKT) was placed in a mold containing 5%-20% GO ice templating slurry, and the ice templating method was used to make the slurry grow into the hollow tube. The obtained body was freeze-dried for 24-48 hours to obtain a GO bioceramic scaffold with imitation hot dog structure.

[010...

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Abstract

The invention relates to a bioactive stent of a hotdog-like structure and a preparation method and application thereof. The bioactive stent comprises a hollow tube made from a bioactive material and arod made from the bioactive material and located in the hollow tube made from the bioactive material, and the rod made from the bioactive material has a continuous and layered structure.

Description

technical field [0001] The invention relates to a biologically active scaffold with a hot dog imitation structure and a preparation method and application thereof, belonging to the field of biological materials. Background technique [0002] As an important technology in the engineering field, 3D printing has been applied and developed in many aspects. However, due to the limitations of 3D printing itself, it is more widely used in the macro-manufacturing of materials. For the design of the micro-nano scale structure of 3D printed scaffolds, few people have achieved it. However, for the application of materials, the design of micro-nano scale has great performance in all aspects of the material [1-4]. Therefore, it is particularly important to realize the microstructure design of 3D printing. The repair of large bone defects has always been a clinical challenge in modern medicine, and the implantation of 3D-printed porous bioscaffolds is currently a commonly used method for...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/28A61L27/54A61L27/50
CPCA61F2/28A61F2002/2835A61F2002/30235A61F2002/30985A61L27/50A61L27/54A61L2300/604A61L2430/02
Inventor 吴成铁李天常江翟东
Owner 中科硅诺(太仓)生物材料科技有限公司
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