Application of compound in preparation of medicines

A compound, drug technology, applied in the field of biomedicine

Inactive Publication Date: 2019-03-01
TSINGHUA UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Unfortunately, there are currently no drugs that can effectively treat or prevent Diffuse Intrinsic Brainstem Gliomas

Method used

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  • Application of compound in preparation of medicines
  • Application of compound in preparation of medicines
  • Application of compound in preparation of medicines

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0118] 1. Experimental materials

[0119] Patient-derived Diffuse Intrinsic Brain Stem Glioma Cell Line, Hematoxylin Eosin Stain, Propidium Iodide Cell Cycle Detection Kit, Ki67 Flow Cytometry Dye, Cell Senescence β-Galactosidase Staining Kit, B -NDG immunodeficiency mice, immunohistochemical kits, CCNA, CCNE, CDK4, CDK6 detection primers, drug Palbociclib, lactic acid, stereotaxic instrument, p-RB-Ser780 antibody, basement membrane matrix (356243, BD, 1%, 4-12h at 37℃), DMEM (C11995500BT, Invitrogen), B27 (1:50), N2 (1:100), insulin (20μg / mL), bFGF (20ng / mL), EGF (20ng / mL), PDGF-AB (20 ng / mL) (PeproTech).

[0120] 2. Experimental process

[0121] 1. To establish a patient-derived diffuse endogenous brainstem glioma cell line.

[0122] The surgically obtained brainstem glioma samples were digested into primary cell line cultures. First rinse with buffer to remove blood clots and necrotic tissue. Cut the sample into pieces, wash with buffer several times, enzymatically dig...

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Abstract

The invention relates to an application of a compound shown in a formula (I) or a stereoisomer shown in the formula (I), a geometric isomer, a tautomer, nitrogen oxides, hydrates, solvates, metabolites, pharmaceutically-acceptable salts or prodrugs in the preparation of medicines. The medicine is used for treating or preventing diffuse endogenous brainstem glioma.

Description

technical field [0001] The present invention relates to the field of biomedicine, in particular, the present invention relates to the use of compounds in the preparation of medicines. Background technique [0002] Brainstem glioma is a type of low-grade malignant glioma, more than 95% of which are derived from astrocytes. It accounts for 10% of children's brain tumors, mainly fibrous astrocytomas, mostly located at the base of the pons. Brainstem gliomas have the characteristic of diffuse growth along the long conduction tract nerve fibers in the brainstem. These tumors tend to dedifferentiate and can develop into anaplastic astrocytoma or even glioblastoma multiforme. Brainstem gliomas can be roughly divided into four types, among which diffuse endogenous brainstem gliomas are mostly located in the pons, which is the most typical brainstem glioma, accounting for 80%, and is also the type with the worst prognosis. Regrettably, there are currently no drugs that can effecti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/519A61K45/06A61P35/00
CPCA61K31/519A61K45/06A61P35/00
Inventor 郗乔然张力伟孙晔孙宇
Owner TSINGHUA UNIV
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